Gene name:
Zcchc11(Kiaa0191;Tut4);
Protein name:
Terminal uridylyltransferase 4(TUTase 4);
Alternative:
Zinc finger CCHC domain-containing protein 11;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with LIN28A, LIN28B and T2BP.
Function:
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
Subcellular Location:
Nucleus
Cytoplasm
Translocates into the cytoplasm following treatment of the cell with LPS.
Protein Attributes:
50:
MEEPKTSKNE | NHEPKKNIIC | EESKAVKIIS | NQTLKPRNDK | SEIGTSSLNR |
100:
NSSKKTKQND | ICIEKTEAKS | CKVNAASVPG | PKDLGLVHRD | QSHCKMKKLP |
150:
NSPMKAQKGS | SQTKLEKTPS | LQTKAEKVPK | SPNLPVKAEK | APCTTAEATT |
200:
EKALNSQRKE | ENTPTSQMKL | QKTPRSPLEP | ENVPSLLLKE | NVKQTESQQT |
250:
GKKLTSSFVS | MDKRKSEALQ | GEKSALENSS | LSQKQQTQTD | NIADSDDSAS |
300:
GIEDTADDLS | KMKSEESNKE | NSSEMDYLEN | ATVIDESALT | PEQRLGLKQA |
350:
EERLERDHIF | RLEKRSPEYT | NCRYLCKLCL | IHIENIQGAH | KHIKEKRHKK |
400:
NILEKQEESE | LRSLPSPSSA | HLAALSVAVV | ELAKEQGITD | DDLRIRQDIV |
450:
EEMSKVIMTF | LPECSLRLYG | SSLTKFALKS | SDVNIDIKFP | PKMNHPDLLI |
500:
QVLGILKKSA | LYIDVESDFH | AKVPVVVCKD | RKSALLCRVS | AGNDMACLTT |
550:
DLLAALGKVE | PVFTPLVLAF | RYWAKLCYID | SQTDGGIPSY | CFALMVMFFL |
600:
QQRKPPLLPC | LLGSWIEGFD | PKRMDDFQLK | GIVEEKFVKW | EYNSSSATEK |
650:
NLIADENKAK | ADEPKDDTKK | TETDNQSNAA | KAKHGKSPLT | LEAPNQVPLG |
700:
QLWLELLKFY | TLDFALEEYV | ICVRIQDILT | RENKNWPKRR | IAIEDPFSVK |
750:
RNVARSLNSQ | LVYEYVVERF | RAAYRYFACP | QKKGGNKSTM | DPKKKEKGKL |
800:
SSKKPVKSDC | SATNCCILGE | SAEKIHMERG | QPAKHDETEF | TSQRCIVDND |
850:
SLLVNELGLA | NHGQDSSSLS | TASGGSDLKQ | KSAEKQGDLT | PSETSLKKEL |
900:
SQCICIGTPD | GAESAGTDCR | SNLEMDSSHQ | IVCNNVSATS | CNCKATEVTS |
950:
DLVDEDNLPS | QELYYVFDKF | ILTSGKPPTI | VCSICKKDGH | SKNDCPEDFR |
1000:
KIDLKPLPPM | TNRFREILDL | VCKRCFDELS | PPCSEQHNRE | QILIGLEKFI |
1050:
QKEYDEKARL | CLFGSSKNGF | GFRDSDLDIC | MTLEGHENAE | KLNCKEIIEN |
1100:
LAKILKRHPG | LRNILPITTA | KVPIVKFEHR | RSGLEGDISL | YNTLAQHNTR |
1150:
MLATYAAIDP | RVQYLGYTMK | VFAKRCDIGD | ASRGSLSSYA | YILMVLYFLQ |
1200:
QRKPPVIPVL | QEIFDGKQIP | QRMVDGWNAF | FFDKTEELKK | RLPSLGKNTE |
1250:
SLGELWLGLL | RFYTEEFDFK | EYVISIRQKK | LLTTFEKQWT | SKCIAIEDPF |
1300:
DLNHNLGAGV | SRKMTNFIMK | AFINGRKLFG | TPFYPLIGRE | AEYFFDSRVL |
1350:
TDGELAPNDR | CCRVCGKIGH | YMKDCPKRKR | LKKKDSEEEK | EGNEEEKDSR |
1400:
DLLDSRDLRC | FICGDAGHVR | RECPEVKMAR | QRNSSVAAAQ | LVRNLVNAQQ |
1450:
VAGSAQQQSD | QSIRTRQSSE | CSDSPSYSPQ | PQPFPQNSPQ | PSALPPPPSQ |
1500:
PGSQPKLGPP | QQGGQPPHQV | QMPLYNFPQS | PPAHYSPMHS | MGLLPMHPLQ |
1550:
IPAPSWPIHG | PMLHSAPGST | PSNIGLNDPS | IIFAQPAARP | MAIPSPSHDG |
1600:
HWPRTVAPNS | LVNNGAVGNS | EPRFRGLNPP | IPWEHAPRHF | PLVPASWPYG |
1644:
LHQNFMHQGN | PRFQPKPFYA | QADRCATRRC | RERCPHPPRG | NVSE

Vaild Sequence:
Related Databases
Uniprot: