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Index > Protein center > Zcchc11(Gene name) > Mouse
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  • Zcchc11 (Gene name),
  • Terminal uridylyltransferase 4 (Protein name ),  TUT4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Zcchc11(Kiaa0191;Tut4);
    Protein name:
    Terminal uridylyltransferase 4(TUTase 4);
    Alternative:
    Zinc finger CCHC domain-containing protein 11;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with LIN28A, LIN28B and T2BP.
    Function:
    Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
    Subcellular Location:
    Nucleus Cytoplasm Translocates into the cytoplasm following treatment of the cell with LPS.
    Protein Attributes:
    Sequence length:
    1644
    Sequence:
    50:
    MEEPKTSKNE | NHEPKKNIIC | EESKAVKIIS | NQTLKPRNDK | SEIGTSSLNR | 
    100:
    NSSKKTKQND | ICIEKTEAKS | CKVNAASVPG | PKDLGLVHRD | QSHCKMKKLP | 
    150:
    NSPMKAQKGS | SQTKLEKTPS | LQTKAEKVPK | SPNLPVKAEK | APCTTAEATT | 
    200:
    EKALNSQRKE | ENTPTSQMKL | QKTPRSPLEP | ENVPSLLLKE | NVKQTESQQT | 
    250:
    GKKLTSSFVS | MDKRKSEALQ | GEKSALENSS | LSQKQQTQTD | NIADSDDSAS | 
    300:
    GIEDTADDLS | KMKSEESNKE | NSSEMDYLEN | ATVIDESALT | PEQRLGLKQA | 
    350:
    EERLERDHIF | RLEKRSPEYT | NCRYLCKLCL | IHIENIQGAH | KHIKEKRHKK | 
    400:
    NILEKQEESE | LRSLPSPSSA | HLAALSVAVV | ELAKEQGITD | DDLRIRQDIV | 
    450:
    EEMSKVIMTF | LPECSLRLYG | SSLTKFALKS | SDVNIDIKFP | PKMNHPDLLI | 
    500:
    QVLGILKKSA | LYIDVESDFH | AKVPVVVCKD | RKSALLCRVS | AGNDMACLTT | 
    550:
    DLLAALGKVE | PVFTPLVLAF | RYWAKLCYID | SQTDGGIPSY | CFALMVMFFL | 
    600:
    QQRKPPLLPC | LLGSWIEGFD | PKRMDDFQLK | GIVEEKFVKW | EYNSSSATEK | 
    650:
    NLIADENKAK | ADEPKDDTKK | TETDNQSNAA | KAKHGKSPLT | LEAPNQVPLG | 
    700:
    QLWLELLKFY | TLDFALEEYV | ICVRIQDILT | RENKNWPKRR | IAIEDPFSVK | 
    750:
    RNVARSLNSQ | LVYEYVVERF | RAAYRYFACP | QKKGGNKSTM | DPKKKEKGKL | 
    800:
    SSKKPVKSDC | SATNCCILGE | SAEKIHMERG | QPAKHDETEF | TSQRCIVDND | 
    850:
    SLLVNELGLA | NHGQDSSSLS | TASGGSDLKQ | KSAEKQGDLT | PSETSLKKEL | 
    900:
    SQCICIGTPD | GAESAGTDCR | SNLEMDSSHQ | IVCNNVSATS | CNCKATEVTS | 
    950:
    DLVDEDNLPS | QELYYVFDKF | ILTSGKPPTI | VCSICKKDGH | SKNDCPEDFR | 
    1000:
    KIDLKPLPPM | TNRFREILDL | VCKRCFDELS | PPCSEQHNRE | QILIGLEKFI | 
    1050:
    QKEYDEKARL | CLFGSSKNGF | GFRDSDLDIC | MTLEGHENAE | KLNCKEIIEN | 
    1100:
    LAKILKRHPG | LRNILPITTA | KVPIVKFEHR | RSGLEGDISL | YNTLAQHNTR | 
    1150:
    MLATYAAIDP | RVQYLGYTMK | VFAKRCDIGD | ASRGSLSSYA | YILMVLYFLQ | 
    1200:
    QRKPPVIPVL | QEIFDGKQIP | QRMVDGWNAF | FFDKTEELKK | RLPSLGKNTE | 
    1250:
    SLGELWLGLL | RFYTEEFDFK | EYVISIRQKK | LLTTFEKQWT | SKCIAIEDPF | 
    1300:
    DLNHNLGAGV | SRKMTNFIMK | AFINGRKLFG | TPFYPLIGRE | AEYFFDSRVL | 
    1350:
    TDGELAPNDR | CCRVCGKIGH | YMKDCPKRKR | LKKKDSEEEK | EGNEEEKDSR | 
    1400:
    DLLDSRDLRC | FICGDAGHVR | RECPEVKMAR | QRNSSVAAAQ | LVRNLVNAQQ | 
    1450:
    VAGSAQQQSD | QSIRTRQSSE | CSDSPSYSPQ | PQPFPQNSPQ | PSALPPPPSQ | 
    1500:
    PGSQPKLGPP | QQGGQPPHQV | QMPLYNFPQS | PPAHYSPMHS | MGLLPMHPLQ | 
    1550:
    IPAPSWPIHG | PMLHSAPGST | PSNIGLNDPS | IIFAQPAARP | MAIPSPSHDG | 
    1600:
    HWPRTVAPNS | LVNNGAVGNS | EPRFRGLNPP | IPWEHAPRHF | PLVPASWPYG | 
    1644:
    LHQNFMHQGN | PRFQPKPFYA | QADRCATRRC | RERCPHPPRG | NVSE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse TUTase 4
    ELISA Kit for Mouse TUTase 4
    CLIA Kit for Mouse TUTase 4
    CLIA Kit for Mouse TUTase 4
    Polyclonal Antibody for Mouse TUTase 4
    Polyclonal Antibody for Mouse TUTase 4
    Monoclonal Antibody for Mouse TUTase 4
    Monoclonal Antibody for Mouse TUTase 4
    Protein for Mouse TUTase 4
    Protein for Mouse TUTase 4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-1644
      tissue: Brain.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 753-1644
      strain: C57BL/6J.
      tissue: Testis.
    5. 5.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "Zcchc11-dependent uridylation of microRNA directs cytokine expression."
      Jones M.R. , Quinton L.J. , Blahna M.T. , Neilson J.R. , Fu S. , Ivanov A.R. , Wolf D.A. , Mizgerd J.P.
      Nat. Cell Biol.11:1157-1163(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;MUTAGENESIS OF ASP-1026 AND ASP-1028
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