Protein name:
Non-receptor tyrosine-protein kinase TYK2 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with JAKMIP1.
Function:
Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.
Subcellular Location:
N/A
Protein Attributes:
50:
MPLCGRRAIL | EDSKADGTEA | QPLVPTGCLM | VLLHWPGPEG | GEPWVTFSQT |
100:
SLTAEEVCIH | IAHKVGITPP | CLNLFALYNA | QAKVWLPPNH | ILDTSQDMNL |
150:
YFRMRFYFRN | WHGMNPQEPA | VYRCGFPGAE | TSSDRAEQGV | QLLDSASFEY |
200:
LFEQGKHEFM | NDVVSLRDLS | SEEEIHHFKN | ESLGMAFLHL | CHLALSRGVP |
250:
LEEMAREISF | KNCIPHSFRQ | HIRQHNVLTR | LRLHRVFRRF | LRAFRPGHLS |
300:
QQVVMVKYLA | TLERLAPRFG | SERIPVCHLE | VLAQPERDPC | YIQNSGQTAG |
350:
DPGPELPSGP | PTHEVLVTGT | GGIQWHPLQT | QESERGNSRG | NPHGSRSGKK |
400:
PKAPKAGEHL | TESPQEPPWT | YFCDFQDISH | VVLKERRVHI | HLQDNKCLLL |
450:
CLCSQAEALS | FVALVDGYFR | LTADSSHYLC | HEVAPPRLVT | SIQNGIHGPL |
500:
MDPFVQAKLW | PEDGLYLIQW | STSHLHRLIL | TVAHRNPAXS | NGPRGLRLRK |
550:
FPITQQPGAF | VLDGWGRSFA | SLGDLRLALQ | GCSLRAGDDC | FPLHXCCLPR |
600:
PREISNLVIM | RGSRAHTRPL | NLSQLSFHRV | HQDEITQLSH | LGQGTRTNVY |
650:
EGLLRVGGPD | EGKVDNGCPP | EPGGTSGQQL | RVVLKVLDPS | HHDIALAFYE |
700:
XASLMSQVSH | MHLAFLHGVC | VRGSENIIVT | EFVEHGPLDV | WLRRQRGQVP |
750:
MTWKMVVAQQ | LASALSYLED | KNLVHGNVCG | RNILLARLGL | EEGTNPFIKL |
800:
SDPGVGQGAL | SREERVERIP | WTAPECLSGG | TSSLGTATDM | WGFGATLLEI |
850:
CFDGEAPLQG | RGPSEKERFY | TKKHQLPEPS | CPELATLTRQ | CLTYEPAQRP |
900:
SFRTILRDLT | RLQPQNLVGT | SAVNSDSPAS | DPTVFHKRYL | KKIRDLGEGH |
950:
FGKVSLYCYD | PTNDGTGEMV | AVKALKEGCG | PQLRSGWQRE | IEILRTLYHE |
1000:
HIVKYKGCCE | DQGEKSVQLV | MEYVPLGSLR | DYLPRHCVGL | AQLLLFAQQI |
1050:
CEGMAYLHAQ | HYIHRDLAAR | NVLLDNDRLV | KIGDFGLAKA | VPEGHEYYRV |
1100:
REDGDSPVFW | YAPECLKECK | FYYASDVWSF | GVTLYELLTY | CDSNQSPHTK |
1150:
FTELIGHTQG | QMTVLRLTEL | LERGERLPRP | DRCPCEIYHL | MKNCWETEAS |
1180:
FRPTFQNLVP | ILQTAQEKYQ | GQVPSVFSVC |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
ELISA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
CLIA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
CLIA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
Polyclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
Polyclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
Monoclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
Monoclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
Protein for Mouse Non-receptor tyrosine-protein kinase TYK2
Protein for Mouse Non-receptor tyrosine-protein kinase TYK2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Partial impairment of cytokine responses in Tyk2-deficient mice."
Karaghiosoff M.
,
Neubauer H.
,
Lassnig C.
,
Kovarik P.
,
Schindler H.
,
Pircher H.
,
McCoy B.
,
Bogdan C.
,
Decker T.
,
Brem G.
,
Pfeffer K.
,
Mueller M.
Immunity13:549-560(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE
strain :
129/Sv .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 732-737;IDENTIFICATION BY MASS SPECTROMETRY
strain :
OF1 .
tissue :
Hippocampus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 769-1180
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-600;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Mast cell .
5.
"Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor."
Argiriadi M.A.
,
Goedken E.R.
,
Banach D.
,
Borhani D.W.
,
Burchat A.
,
Dixon R.W.
,
Marcotte D.
,
Overmeyer G.
,
Pivorunas V.
,
Sadhukhan R.
,
Sousa S.
,
Moore N.S.
,
Tomlinson M.
,
Voss J.
,
Wang L.
,
Wishart N.
,
Woller K.
,
Talanian R.V.
BMC Struct. Biol.12:22-22(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 880-1170 IN COMPLEX WITH INHIBITOR