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Index > Protein center > Tyk2(Gene name) > Mouse
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  • Tyk2 (Gene name),
  • Non-receptor tyrosine-protein kinase TYK2 (Protein name ),  TYK2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Tyk2;
    Protein name:
    Non-receptor tyrosine-protein kinase TYK2;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with JAKMIP1.
    Function:
    Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    1180
    Sequence:
    50:
    MPLCGRRAIL | EDSKADGTEA | QPLVPTGCLM | VLLHWPGPEG | GEPWVTFSQT | 
    100:
    SLTAEEVCIH | IAHKVGITPP | CLNLFALYNA | QAKVWLPPNH | ILDTSQDMNL | 
    150:
    YFRMRFYFRN | WHGMNPQEPA | VYRCGFPGAE | TSSDRAEQGV | QLLDSASFEY | 
    200:
    LFEQGKHEFM | NDVVSLRDLS | SEEEIHHFKN | ESLGMAFLHL | CHLALSRGVP | 
    250:
    LEEMAREISF | KNCIPHSFRQ | HIRQHNVLTR | LRLHRVFRRF | LRAFRPGHLS | 
    300:
    QQVVMVKYLA | TLERLAPRFG | SERIPVCHLE | VLAQPERDPC | YIQNSGQTAG | 
    350:
    DPGPELPSGP | PTHEVLVTGT | GGIQWHPLQT | QESERGNSRG | NPHGSRSGKK | 
    400:
    PKAPKAGEHL | TESPQEPPWT | YFCDFQDISH | VVLKERRVHI | HLQDNKCLLL | 
    450:
    CLCSQAEALS | FVALVDGYFR | LTADSSHYLC | HEVAPPRLVT | SIQNGIHGPL | 
    500:
    MDPFVQAKLW | PEDGLYLIQW | STSHLHRLIL | TVAHRNPAXS | NGPRGLRLRK | 
    550:
    FPITQQPGAF | VLDGWGRSFA | SLGDLRLALQ | GCSLRAGDDC | FPLHXCCLPR | 
    600:
    PREISNLVIM | RGSRAHTRPL | NLSQLSFHRV | HQDEITQLSH | LGQGTRTNVY | 
    650:
    EGLLRVGGPD | EGKVDNGCPP | EPGGTSGQQL | RVVLKVLDPS | HHDIALAFYE | 
    700:
    XASLMSQVSH | MHLAFLHGVC | VRGSENIIVT | EFVEHGPLDV | WLRRQRGQVP | 
    750:
    MTWKMVVAQQ | LASALSYLED | KNLVHGNVCG | RNILLARLGL | EEGTNPFIKL | 
    800:
    SDPGVGQGAL | SREERVERIP | WTAPECLSGG | TSSLGTATDM | WGFGATLLEI | 
    850:
    CFDGEAPLQG | RGPSEKERFY | TKKHQLPEPS | CPELATLTRQ | CLTYEPAQRP | 
    900:
    SFRTILRDLT | RLQPQNLVGT | SAVNSDSPAS | DPTVFHKRYL | KKIRDLGEGH | 
    950:
    FGKVSLYCYD | PTNDGTGEMV | AVKALKEGCG | PQLRSGWQRE | IEILRTLYHE | 
    1000:
    HIVKYKGCCE | DQGEKSVQLV | MEYVPLGSLR | DYLPRHCVGL | AQLLLFAQQI | 
    1050:
    CEGMAYLHAQ | HYIHRDLAAR | NVLLDNDRLV | KIGDFGLAKA | VPEGHEYYRV | 
    1100:
    REDGDSPVFW | YAPECLKECK | FYYASDVWSF | GVTLYELLTY | CDSNQSPHTK | 
    1150:
    FTELIGHTQG | QMTVLRLTEL | LERGERLPRP | DRCPCEIYHL | MKNCWETEAS | 
    1180:
    FRPTFQNLVP | ILQTAQEKYQ | GQVPSVFSVC | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
    Cat.:
    E1595h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
    Cat.:
    E1595m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
    Cat.:
    U1595h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Non-receptor tyrosine-protein kinase TYK2
    Cat.:
    U1595m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
    Cat.:
    P1595Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
    Cat.:
    P1595Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
    Monoclonal Antibody for Mouse Non-receptor tyrosine-protein kinase TYK2
    Protein for Mouse Non-receptor tyrosine-protein kinase TYK2
    Protein for Mouse Non-receptor tyrosine-protein kinase TYK2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
      strain: 129/Sv.
      tissue: Liver.
    2. 2.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 732-737;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 769-1180
    4. 4.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-600;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    5. 5.
      "Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor."
      Argiriadi M.A. , Goedken E.R. , Banach D. , Borhani D.W. , Burchat A. , Dixon R.W. , Marcotte D. , Overmeyer G. , Pivorunas V. , Sadhukhan R. , Sousa S. , Moore N.S. , Tomlinson M. , Voss J. , Wang L. , Wishart N. , Woller K. , Talanian R.V.
      BMC Struct. Biol.12:22-22(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 880-1170 IN COMPLEX WITH INHIBITOR
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