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Index > Protein center > Tyrobp(Gene name) > Mouse
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  • Tyrobp (Gene name),
  • TYRO protein tyrosine kinase-binding protein (Protein name ),  TYOBP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Tyrobp(Dap12;Karap);
    Protein name:
    TYRO protein tyrosine kinase-binding protein;
    Alternative:
    Killer-activating receptor-associated protein(KAR-associated protein);DNAX-activation protein 12;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Interacts with SIRPB1 and TREM1. Interacts with SIGLEC14 (By similarity). Interacts with CLECSF5. Interacts with CD300LB and CD300D. Interacts with CD300E. Interacts with KLRC2 and KIR2DS3.
    Function:
    Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    114
    Sequence:
    50:
    MGALEPSWCL | LFLPVLLTVG | GLSPVQAQSD | TFPRCDCSSV | SPGVLAGIVL | 
    100:
    GDLVLTLLIA | LAVYSLGRLV | SRGQGTAEGT | RKQHIAETES | PYQELQGQRP | 
    114:
    EVYSDLNTQR | QYYR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    Uniprot:
     
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    ELISA Kit for Mouse TYRO protein tyrosine kinase-binding protein
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    CLIA Kit for Mouse TYRO protein tyrosine kinase-binding protein
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    CLIA Kit for Mouse TYRO protein tyrosine kinase-binding protein
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    CLIA Kit for Mouse TYRO protein tyrosine kinase-binding protein
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    CLIA Kit for Mouse TYRO protein tyrosine kinase-binding protein
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    CLIA Kit for Mouse TYRO protein tyrosine kinase-binding protein
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    Polyclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
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    P12665Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Polyclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Polyclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Polyclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Monoclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Monoclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Monoclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Monoclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Monoclonal Antibody for Mouse TYRO protein tyrosine kinase-binding protein
    Protein for Mouse TYRO protein tyrosine kinase-binding protein
    Protein for Mouse TYRO protein tyrosine kinase-binding protein
    Protein for Mouse TYRO protein tyrosine kinase-binding protein
    Protein for Mouse TYRO protein tyrosine kinase-binding protein
    Protein for Mouse TYRO protein tyrosine kinase-binding protein

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    References
    1. 1.
      "Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells."
      Lanier L.L. , Corliss B.C. , Wu J. , Leong C. , Phillips J.H.
      Nature391:703-707(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6J.
    2. 2.
      "Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12."
      Tomasello E. , Olcese L. , Vely F. , Geourgeon C. , Blery M. , Moqrich A. , Gautheret D. , Djabali M. , Mattei M.-G. , Vivier E.
      J. Biol. Chem.273:34115-34119(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells."
      Bakker A.B.H. , Baker E. , Sutherland G.R. , Phillips J.H. , Lanier L.L.
      Proc. Natl. Acad. Sci. U.S.A.96:9792-9796(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLECSF5
    5. 5.
      "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D."
      Diefenbach A. , Tomasello E. , Lucas M. , Jamieson A.M. , Hsia J.K. , Vivier E. , Raulet D.H.
      Nat. Immunol.3:1142-1149(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLRK1
    6. 6.
      "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation."
      Gilfillan S. , Ho E.L. , Cella M. , Yokoyama W.M. , Colonna M.
      Nat. Immunol.3:1150-1155(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLRK1
    7. 7.
      "Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells."
      Kumagai H. , Oki T. , Tamitsu K. , Feng S.-Z. , Ono M. , Nakajima H. , Bao Y.-C. , Kawakami Y. , Nagayoshi K. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Kawakami T. , Kitamura T.
      Biochem. Biophys. Res. Commun.307:719-729(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD300D
    8. 8.
      "Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation."
      Yotsumoto K. , Okoshi Y. , Shibuya K. , Yamazaki S. , Tahara-Hanaoka S. , Honda S. , Osawa M. , Kuroiwa A. , Matsuda Y. , Tenen D.G. , Iwama A. , Nakauchi H. , Shibuya A.
      J. Exp. Med.198:223-233(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD300D
    9. 9.
      "A Structural basis for the association of DAP12 with mouse, but not human, NKG2D."
      Rosen D.B. , Araki M. , Hamerman J.A. , Chen T. , Yamamura T. , Lanier L.L.
      J. Immunol.173:2470-2478(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLRK1
    10. 10.
      "Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs."
      Mocsai A. , Abram C.L. , Jakus Z. , Hu Y. , Lanier L.L. , Lowell C.A.
      Nat. Immunol.7:1326-1333(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTEGRIN-MEDIATED NEUTROPHIL ACTIVATION;INTERACTION WITH SYK
    11. 11.
      "Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages."
      Nakahashi C. , Tahara-Hanaoka S. , Totsuka N. , Okoshi Y. , Takai T. , Ohkohchi N. , Honda S. , Shibuya K. , Shibuya A.
      J. Immunol.178:765-770(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD300D
    12. 12.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-92 AND TYR-103;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    13. 13.
      "Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells."
      Yamanishi Y. , Kitaura J. , Izawa K. , Matsuoka T. , Oki T. , Lu Y. , Shibata F. , Yamazaki S. , Kumagai H. , Nakajima H. , Maeda-Yamamoto M. , Tybulewicz V.L.J. , Takai T. , Kitamura T.
      Blood111:688-698(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CD300LB
    14. 14.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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