Gene name:
TYW5 (C2orf60) ;
Protein name:
tRNA wybutosine-synthesizing protein 5 (hTYW5) ;
Alternative:
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
Subcellular Location:
N/A
Protein Attributes:
50:
MAGQHLPVPR | LEGVSREQFM | QHLYPQRKPL | VLEGIDLGPC | TSKWTVDYLS |
100:
QVGGKKEVKI | HVAAVAQMDF | ISKNFVYRTL | PFDQLVQRAA | EEKHKEFFVS |
150:
EDEKYYLRSL | GEDPRKDVAD | IRKQFPLLKG | DIKFPEFFKE | EQFFSSVFRI |
200:
SSPGLQLWTH | YDVMDNLLIQ | VTGKKRVVLF | SPRDAQYLYL | KGTKSEVLNI |
250:
DNPDLAKYPL | FSKARRYECS | LEAGDVLFIP | ALWFHNVISE | EFGVGVNIFW |
300:
KHLPSECYDK | TDTYGNKDPT | AASRAAQILD | RALKTLAELP | EEYRDFYARR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Mouse
Human
ELISA Kit for Human hTYW5
ELISA Kit for Human hTYW5
ELISA Kit for Human hTYW5
Polyclonal Antibody for Human hTYW5
Polyclonal Antibody for Human hTYW5
Polyclonal Antibody for Human hTYW5
Monoclonal Antibody for Human hTYW5
Monoclonal Antibody for Human hTYW5
Monoclonal Antibody for Human hTYW5
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Tongue .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Retinoblastoma .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;PATHWAY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 4-311 IN COMPLEX WITH 2-OXOGLUTARATE AND NICKEL ION;PATHWAY;COFACTOR;SUBUNIT;MUTAGENESIS OF ARG-108 AND ARG-149