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Index > Protein center > TYW5(Gene name) > Human
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  • TYW5 (Gene name),
  • tRNA wybutosine-synthesizing protein 5 (Protein name ),  TYW5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TYW5(C2orf60);
    Protein name:
    tRNA wybutosine-synthesizing protein 5(hTYW5);
    Alternative:
    tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    315
    Sequence:
    50:
    MAGQHLPVPR | LEGVSREQFM | QHLYPQRKPL | VLEGIDLGPC | TSKWTVDYLS | 
    100:
    QVGGKKEVKI | HVAAVAQMDF | ISKNFVYRTL | PFDQLVQRAA | EEKHKEFFVS | 
    150:
    EDEKYYLRSL | GEDPRKDVAD | IRKQFPLLKG | DIKFPEFFKE | EQFFSSVFRI | 
    200:
    SSPGLQLWTH | YDVMDNLLIQ | VTGKKRVVLF | SPRDAQYLYL | KGTKSEVLNI | 
    250:
    DNPDLAKYPL | FSKARRYECS | LEAGDVLFIP | ALWFHNVISE | EFGVGVNIFW | 
    300:
    KHLPSECYDK | TDTYGNKDPT | AASRAAQILD | RALKTLAELP | EEYRDFYARR | 
    315:
    MVLHIQDKAY | SKNSE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human hTYW5
    ELISA Kit for Human hTYW5
    ELISA Kit for Human hTYW5
    CLIA Kit for Human hTYW5
    CLIA Kit for Human hTYW5
    CLIA Kit for Human hTYW5
    Polyclonal Antibody for Human hTYW5
    Polyclonal Antibody for Human hTYW5
    Polyclonal Antibody for Human hTYW5
    Monoclonal Antibody for Human hTYW5
    Monoclonal Antibody for Human hTYW5
    Monoclonal Antibody for Human hTYW5
    Protein for Human hTYW5
    Protein for Human hTYW5
    Protein for Human hTYW5

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Tongue.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Retinoblastoma.
    5. 5.
      "Expanding role of the jumonji C domain as an RNA hydroxylase."
      Noma A. , Ishitani R. , Kato M. , Nagao A. , Nureki O. , Suzuki T.
      J. Biol. Chem.285:34503-34507(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PATHWAY
    6. 6.
      "Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification."
      Kato M. , Araiso Y. , Noma A. , Nagao A. , Suzuki T. , Ishitani R. , Nureki O.
      Nucleic Acids Res.39:1576-1585(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 4-311 IN COMPLEX WITH 2-OXOGLUTARATE AND NICKEL ION;PATHWAY;COFACTOR;SUBUNIT;MUTAGENESIS OF ARG-108 AND ARG-149
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