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Index > Protein center > UAP1(Gene name) > Human
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  • UAP1 (Gene name),
  • UDP-N-acetylhexosamine pyrophosphorylase (Protein name ),  UAP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UAP1(SPAG2);
    Protein name:
    UDP-N-acetylhexosamine pyrophosphorylase;
    Alternative:
    Sperm-associated antigen 2;Antigen X(AGX);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer and homodimer. Isoform AGX1 is a homodimer. Isoform AGX2 is a monomer.
    Function:
    Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
    Subcellular Location:
    Cytoplasm In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
    Protein Attributes:
    Sequence length:
    522
    Sequence:
    50:
    MNINDLKLTL | SKAGQEHLLR | FWNELEEAQQ | VELYAELQAM | NFEELNFFFQ | 
    100:
    KAIEGFNQSS | HQKNVDARME | PVPREVLGSA | TRDQDQLQAW | ESEGLFQISQ | 
    150:
    NKVAVLLLAG | GQGTRLGVAY | PKGMYDVGLP | SRKTLFQIQA | ERILKLQQVA | 
    200:
    EKYYGNKCII | PWYIMTSGRT | MESTKEFFTK | HKYFGLKKEN | VIFFQQGMLP | 
    250:
    AMSFDGKIIL | EEKNKVSMAP | DGNGGLYRAL | AAQNIVEDME | QRGIWSIHVY | 
    300:
    CVDNILVKVA | DPRFIGFCIQ | KGADCGAKVV | EKTNPTEPVG | VVCRVDGVYQ | 
    350:
    VVEYSEISLA | TAQKRSSDGR | LLFNAGNIAN | HFFTVPFLRD | VVNVYEPQLQ | 
    400:
    HHVAQKKIPY | VDTQGQLIKP | DKPNGIKMEK | FVFDIFQFAK | KFVVYEVLRE | 
    450:
    DEFSPLKNAD | SQNGKDNPTT | ARHALMSLHH | CWVLNAGGHF | IDENGSRLPA | 
    500:
    IPRSATNGKS | ETITADVNHN | LKDANDVPIQ | CEISPLISYA | GEGLESYVAD | 
    522:
    KEFHAPLIID | ENGVHELVKN | GI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    SMR:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human UDP-N-acetylhexosamine pyrophosphorylase
    ELISA Kit for Human UDP-N-acetylhexosamine pyrophosphorylase
    CLIA Kit for Human UDP-N-acetylhexosamine pyrophosphorylase
    CLIA Kit for Human UDP-N-acetylhexosamine pyrophosphorylase
    Polyclonal Antibody for Human UDP-N-acetylhexosamine pyrophosphorylase
    Polyclonal Antibody for Human UDP-N-acetylhexosamine pyrophosphorylase
    Monoclonal Antibody for Human UDP-N-acetylhexosamine pyrophosphorylase
    Monoclonal Antibody for Human UDP-N-acetylhexosamine pyrophosphorylase
    Protein for Human UDP-N-acetylhexosamine pyrophosphorylase
    Protein for Human UDP-N-acetylhexosamine pyrophosphorylase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Characterization of a human antigen with sera from infertile patients."
      Diekman A.B. , Goldberg E.
      Biol. Reprod.50:1087-1093(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS AGX1; AGX2 AND 3)
      tissue: Testis.
    2. 2.
      "The eukaryotic UDP-N-acetylglucosamine pyrophosphorylases: gene cloning, protein expression, and catalytic mechanism."
      Mio T. , Yabe T. , Arisawa M. , Yamada-Okabe H.
      J. Biol. Chem.273:14392-14397(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM AGX1)
      tissue: Testis.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM AGX1)
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS AGX1; AGX2 AND 3)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM AGX1)
      tissue: Muscle.
    7. 7.
      "A 17-amino acid insert changes UDP-N-acetylhexosamine pyrophosphorylase specificity from UDP-GalNAc to UDP-GlcNAc."
      Wang-Gillam A. , Pastuszak I. , Elbein A.D.
      J. Biol. Chem.273:27055-27057(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;ALTERNATIVE SPLICING;CATALYTIC ACTIVITY;CHARACTERIZATION
      tissue: Mammary cancer.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture."
      Peneff C. , Ferrari P. , Charrier V. , Taburet Y. , Monnier C. , Zamboni V. , Winter J. , Harnois M. , Fassy F. , Bourne Y.
      EMBO J.20:6191-6202(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEX WITH SUBSTRATE
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