Gene name:
Ube2d2 (Ubc4;Ubch4;Ubch5b;Ube2d2a) ;
Protein name:
Ubiquitin-conjugating enzyme E2 D2 ;
Alternative:
Ubiquitin-conjugating enzyme E2(17)KB 2 ;Ubiquitin carrier protein D2 ;Ubiquitin-protein ligase D2 ;Ubiquitin-conjugating enzyme E2-17 kDa 2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain) (By similarity). Interacts also with E3 ubiquitin-protein ligase PJA2. Interacts with PDZRN3.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.
Subcellular Location:
N/A
Protein Attributes:
50:
MALKRIHKEL | NDLARDPPAQ | CSAGPVGDDM | FHWQATIMGP | NDSPYQGGVF |
100:
FLTIHFPTDY | PFKPPKVAFT | TRIYHPNINS | NGSICLDILR | SQWSPALTIS |
147:
KVLLSICSLL | CDPNPDDPLV | PEIARIYKTD | REKYNRIARE | WTQKYAM
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
Pig
ELISA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
ELISA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
CLIA Kit for Mouse Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Polyclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Monoclonal Antibody for Mouse Ubiquitin-conjugating enzyme E2 D2
Protein for Mouse Ubiquitin-conjugating enzyme E2 D2
Protein for Mouse Ubiquitin-conjugating enzyme E2 D2
Protein for Mouse Ubiquitin-conjugating enzyme E2 D2
Protein for Mouse Ubiquitin-conjugating enzyme E2 D2
Protein for Mouse Ubiquitin-conjugating enzyme E2 D2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Cloning of a murine ubiquitin conjugating enzyme."
Richardson P.
,
Zon L.I.
Submitted (1996-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Mammary tumor .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PJA1
strain :
129/SvJ .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PDZRN3