Ube2j2 ELISA Kit for Mouse(Mus musculus) | EIAab.comUbe2j2 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Ube2j2(Gene name) > Mouse

Ube2j2 (Gene name),

Ubiquitin-conjugating enzyme E2 J2 (Protein name ), UB2J2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Ube2j2(Ncube2);

Protein name:

Ubiquitin-conjugating enzyme E2 J2;

Alternative:

Non-canonical ubiquitin-conjugating enzyme 2(NCUBE-2);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with murid herpesvirus 4 protein K3 (mK3).

Function:

In case of infection by the murid herpesvirus 4, its association with the viral E3 ligase K3 mediates ubiquitination of host surface class I (MHC-I) H-2D(b)/H2-D1 and H-2K(b)/H2-K1 molecules before they exit the endoplasmic reticulum, leading to their degradation by the ERAD system, thus blocking the immune detection of virus-infected cells. The complex formed with the murid herpesvirus 4 protein K3 mediates ubiquitination of lysine, as well as serine and threonine residues present in the cytoplasmic tail of surface class I molecules and promotes ubiquitination of hydroxylated serine or threonine residues via ester bonds instead of the classical isopeptide linkage.

Subcellular Location:

Endoplasmic reticulum membrane Single-pass type IV membrane protein

Protein Attributes:

Sequence length:

259

Sequence:

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259: