UBE2L6 ELISA Kit for Human(Homo sapiens) | EIAab.comUBE2L6 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > UBE2L6(Gene name) > Human

UBE2L6 (Gene name),

Ubiquitin/ISG15-conjugating enzyme E2 L6 (Protein name ), UB2L6_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UBE2L6(UBCH8);

Protein name:

Ubiquitin/ISG15-conjugating enzyme E2 L6;

Alternative:

UbcH8;Retinoic acid-induced gene B protein(RIG-B);Ubiquitin-protein ligase L6;Ubiquitin carrier protein L6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).

Function:

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

153

Sequence:

50:

100:

150:

153:

RPS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:9246

SMR:

O14933

MIM:

603890

UniGene:

Hs.425777

STRING:

9606.ENSP00000287156

Pfam:

PF00179

String:

O14933

Uniprot:

O14933

FOR

ELISA Kit for Human Ubiquitin/ISG15-conjugating enzyme E2 L6

CLIA Kit for Human Ubiquitin/ISG15-conjugating enzyme E2 L6

Polyclonal Antibody for Human Ubiquitin/ISG15-conjugating enzyme E2 L6

Monoclonal Antibody for Human Ubiquitin/ISG15-conjugating enzyme E2 L6

Protein for Human Ubiquitin/ISG15-conjugating enzyme E2 L6

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12."
Ardley H.C. , Rose S.A. , Tan N. , Leek J.P. , Markham A.F. , Robinson P.A.
Cytogenet. Cell Genet.89:137-140(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
2.

"Human retinoic acid induced gene B (RIG-B) mRNA."
Liu T. , Mao M. , Zhang J. , Wu J. , Zhang Q. , Fu G. , Shen Y. , Zhou J. , Yu Y. , Wang Z. , Chen S. , Chen Z.
Submitted (1998-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Thymus.
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2006-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
6.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
9.

"Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity."
Kumar S. , Kao W.H. , Howley P.M.
J. Biol. Chem.272:13548-13554(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-153 (ISOFORM 1)
10.

"The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein."
Zhao C. , Beaudenon S.L. , Kelley M.L. , Waddell M.B. , Yuan W. , Schulman B.A. , Huibregtse J.M. , Krug R.M.
Proc. Natl. Acad. Sci. U.S.A.101:7578-7582(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 140-146;FUNCTION IN ISG15 ATTACHMENT;INDUCTION BY IFNB1
11.

"A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity."
Niwa J. , Ishigaki S. , Doyu M. , Suzuki T. , Tanaka K. , Sobue G.
Biochem. Biophys. Res. Commun.281:706-713(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF19A
12.

"Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme."
Takeuchi T. , Iwahara S. , Saeki Y. , Sasajima H. , Yokosawa H.
J. Biochem.138:711-719(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ISGYLATION
13.

"The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis."
Huang J. , Xu L.-G. , Liu T. , Zhai Z. , Shu H.-B.
FEBS Lett.580:940-947(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF144B
14.

"NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase."
Fortier J.M. , Kornbluth J.
J. Immunol.176:6454-6463(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF19B;TISSUE SPECIFICITY
15.

"Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation."
Buchwald M. , Pietschmann K. , Muller J.P. , Bohmer F.D. , Heinzel T. , Kramer O.H.
Leukemia24:1412-1421(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF FLT3;INTERACTION WITH FLT3
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Crystal structure of Ubch8."
Mizushima T. , Suzuki M. , Teshima N. , Yamane T. , Murata S. , Tanaka K.
Submitted (2005-03) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 2-153
18.

"The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site."
Serniwka S.A. , Shaw G.S.
Biochemistry48:12169-12179(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR IN COMPLEX WITH UBIQUITIN

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