Ube3a ELISA Kit for Mouse(Mus musculus) | EIAab.comUbe3a ELISA Kit for Mouse(Mus musculus)

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Ube3a (Gene name),

Ubiquitin-protein ligase E3A (Protein name ), UBE3A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ube3a;

Protein name:

Ubiquitin-protein ligase E3A;

Alternative:

Oncogenic protein-associated protein E6-AP;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds UBQLN1 and UBQLN2. Interacts with the 26S proteasome. Interacts with BPY2.

Function:

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

885

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

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600:

650:

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850:

885:

HTCFNVLLLP | EYSSKEKLNV | RLLKAITYAK | GFGML

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00632

STRING:

10090.ENSMUSP00000082326

UniGene:

Mm.9002

SMR:

O08759

String:

O08759

Uniprot:

O08759

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ELISA Kit for Mouse Ubiquitin-protein ligase E3A

Cat.:

E9055h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Ubiquitin-protein ligase E3A

Cat.:

E9055m

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96T

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CLIA Kit for Mouse Ubiquitin-protein ligase E3A

Cat.:

U9055h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse Ubiquitin-protein ligase E3A

Cat.:

U9055m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Ubiquitin-protein ligase E3A

Cat.:

P9055Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Ubiquitin-protein ligase E3A

Cat.:

P9055Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Ubiquitin-protein ligase E3A

Protein for Mouse Ubiquitin-protein ligase E3A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases."
Hatakeyama S. , Jensen J.P. , Weissman A.M.
J. Biol. Chem.272:15085-15092(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
strain: C57BL/6 X CBA.
2.

"The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region."
Sutcliffe J.S. , Jiang Y.-H. , Galjaard R.-J. , Matsuura T. , Fang P. , Kubota T. , Christian S.L. , Bressler J. , Cattanach B. , Ledbetter D.H. , Beaudet A.L.
Genome Res.7:368-377(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain: BALB/c.
tissue: Brain.
3.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
4.

"The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor."
Gossan N.C. , Zhang F. , Guo B. , Jin D. , Yoshitane H. , Yao A. , Glossop N. , Zhang Y.Q. , Fukada Y. , Meng Q.J.
Nucleic Acids Res.42:5765-5775(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY

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