Usp13 ELISA Kit for Mouse(Mus musculus) | EIAab.comUsp13 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Usp13 (Gene name),

Ubiquitin carboxyl-terminal hydrolase 13 (Protein name ), UBP13_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Usp13;

Protein name:

Ubiquitin carboxyl-terminal hydrolase 13;

Alternative:

Ubiquitin thioesterase 13;Deubiquitinating enzyme 13;Ubiquitin-specific-processing protease 13;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with UFD1. Interacts (via UBA domains) with SIAH2 (when ubiquitinated).

Function:

Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, thereby regulating endoplasmic reticulum-associated degradation (ERAD). Mediates stabilization of SIAH2 independently of deubiquitinase activity: binds ubiquitinated SIAH2 and acts by impairing SIAH2 autoubiquitination. Has a weak deubiquitinase activity in vitro and preferentially cleaves 'Lys-63'-linked polyubiquitin chains. In contrast to USP5, it is not able to mediate unanchored polyubiquitin disassembly. Able to cleave ISG15 in vitro; however, additional experiments are required to confirm such data.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

858

Sequence:

50:

MQRRGALFSV | PGGGGKMAAG | DLGELLVPHM | PTIRVPRSGD | RVYKNECAFS |

100:

YDSPNSEGGL | YVCMNTFLAF | GREHVERHFR | KTGQSVYMHL | KRHMREKVRG |

150:

ASGGALPKRR | NSKIFLDLDM | DDDLNSDDYE | YEDEAKLVIF | PDHYEIALPN |

200:

IEELPALVTI | ACDAVLSSKS | PYRKQDPDTW | ENEVPVSKYA | NNLVQLDNGV |

250:

RIPPSGWKCA | RCDLRENLWL | NLTDGSVLCG | KWFFDSSGGN | GHALEHYRDM |

300:

GYPLAVKLGT | ITPDGADVYS | FQEEGPVSDP | HLAKHLAHFG | IDMLHTQGTE |

350:

NGLRDNDIKP | RVSEWEVIQE | SGTKLKPMYG | PGYTGLKNLG | NSCYLSSVMQ |

400:

AIFSIPEFQR | AYVGNLPRIF | DYSPLDPTQD | FNTQMTKLGH | GLLSGQYSKP |

450:

PVKSELIEQV | MKEEHKPQQN | GISPRMFKAF | VSKSHPEFSS | NRQQDAQEFF |

500:

LHLVNLVERN | RIGSENPSDV | FRFLVEERIQ | CCQTRKVRYT | ERVDYLMQLP |

550:

VAMEAATNKD | ELITYELMRR | EAEANRRPLP | ELVRAKIPFS | ACLQAFAEPD |

600:

NVDDFWSSAL | QAKSAGVKTS | RFASFPEYLV | VQIKKFTFGL | DWVPRKFDVS |

650:

IDMPDLLDIS | HLRARGLQPG | EEELPDISPP | IVIPDDSKDR | LMNQLIDPSD |

700:

IDESSVMQLA | EMGFPLEACR | KAVYFTGNTG | AEVAFNWIIV | HMEEPDFAEP |

750:

LAIPGYGGAG | ASVFGATGLD | NQPPEEIVAI | ITSMGFQRNQ | AVQALQATNH |

800:

NLERALDWIF | SHPEFEEDSD | FVIEMENNAN | ANIVSEAKPE | GPRVKDGSGM |

850:

YELFAFISHM | GTSTMSGHYV | CHIKKEGRWV | IYNDHKVCAS | ERPPKDLGYM |

858:

YFYRRIPS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

SMR:

Pfam:

STRING:

10090.ENSMUSP00000072155

KEGG:

Uniprot:

FOR

ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 13

Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 13

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Heart.

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