USP16 ELISA Kit for Human(Homo sapiens) | EIAab.comUSP16 ELISA Kit for Human(Homo sapiens)

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USP16 (Gene name),

Ubiquitin carboxyl-terminal hydrolase 16 (Protein name ), UBP16_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

USP16(MSTP039);

Protein name:

Ubiquitin carboxyl-terminal hydrolase 16;

Alternative:

Ubiquitin thiolesterase 16;Deubiquitinating enzyme 16;Ubiquitin-specific-processing protease 16;Ubiquitin-processing protease UBP-M;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer.

Function:

Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

823

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

823:

VQAVPTTKVL | NSQAYLLFYE | RIL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9Y5T5

KEGG:

hsa:10600

SMR:

Q9Y5T5

MIM:

604735

Pfam:

PF00443

UniGene:

Hs.99819

Uniprot:

Q9Y5T5

FOR

ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

E11580m

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96T

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ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

E11580b

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96T

ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

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E11580h

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96T

ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

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E11580r

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96T

CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

U11580m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

U11580b

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Packing:

96T

CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

U11580h

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Packing:

96T

CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

U11580r

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96T

Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

P11580Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

P11580Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 16

Cat.:

P11580Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 16

Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 16

Protein for Human Ubiquitin carboxyl-terminal hydrolase 16

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division."
Cai S.-Y. , Babbitt R.W. , Marchesi V.T.
Proc. Natl. Acad. Sci. U.S.A.96:2828-2833(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;MUTAGENESIS OF CYS-205
2.

Grimbert P. , Pawlak A. , Sahali D.
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);VARIANT HIS-141
tissue: Amygdala.
tissue: Teratocarcinoma.
tissue: Testis.
4.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Liver.
5.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT HIS-141
tissue: Testis.
8.

Liu B. , Liu Y.Q. , Wang X.Y. , Zhao B. , Sheng H. , Zhao X.W. , Liu S. , Xu Y.Y. , Ye J. , Song L. , Gao Y. , Zhang C.L. , Zhang J. , Wei Y.J. , Cao H.Q. , Zhao Y. , Liu L.S. , Ding J.F. , more...
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 139-823
tissue: Aorta.
9.

"Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli."
Mimnaugh E.G. , Kayastha G. , McGovern N.B. , Hwang S.G. , Marcu M.G. , Trepel J. , Cai S.-Y. , Marchesi V.T. , Neckers L.
Cell Death Differ.8:1182-1196(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY FUNCTION;MUTAGENESIS OF CYS-205
10.

"Regulation of cell cycle progression and gene expression by H2A deubiquitination."
Joo H.-Y. , Zhai L. , Yang C. , Nie S. , Erdjument-Bromage H. , Tempst P. , Chang C. , Wang H.
Nature449:1068-1072(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-205
11.

"Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes."
Gelsi-Boyer V. , Trouplin V. , Adelaide J. , Aceto N. , Remy V. , Pinson S. , Houdayer C. , Arnoulet C. , Sainty D. , Bentires-Alj M. , Olschwang S. , Vey N. , Mozziconacci M.-J. , Birnbaum D. , Chaffanet M.
BMC Cancer8:299-299(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL REARRANGEMENT
12.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415 AND SER-552;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552 AND THR-554;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Usp16 contributes to somatic stem-cell defects in Down's syndrome."
Adorno M. , Sikandar S. , Mitra S.S. , Kuo A. , Nicolis Di Robilant B. , Haro-Acosta V. , Ouadah Y. , Quarta M. , Rodriguez J. , Qian D. , Reddy V.M. , Cheshier S. , Garner C.C. , Clarke M.F.
Nature501:380-384(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INVOLVEMENT IN DOWN SYNDROME
19.

"Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin."
Pai M.-T. , Tzeng S.-R. , Kovacs J.J. , Keaton M.A. , Li S.S.-C. , Yao T.-P. , Zhou P.
J. Mol. Biol.370:290-302(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-143;ZINC-BINDING

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