Protein name:
Ubiquitin carboxyl-terminal hydrolase 21 ;
Alternative:
Ubiquitin thiolesterase 21 ;Deubiquitinating enzyme 21 ;Ubiquitin-specific-processing protease 21 ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MPQASEHRLG | RTREPPVNVQ | PRVGAKIPFP | PRARSKERRN | PVPGPNSMLR |
100:
PLPPRPGPPD | ERLKKLELGR | GRTSGSRPRG | PLRADHGVPL | PGSPPPAVAL |
150:
PLPSRTNLAR | SKSVSSGDLR | PMGIALGGHR | GAGELGAALS | RLALRPEPPT |
200:
LRRSTSLRRL | GGFPGPPTLL | SIRTEPPTSH | GSFHMISARP | SEPFYSDDKM |
250:
AHHTLLLGSG | HVGLRNLGNT | CFLNAVLQCL | SSTRPLRDFC | LRRDFRQEVP |
300:
GGGRAQELTE | AFADVIGALW | HPDSCEAVNP | TRFRAVFQKY | VPSFSGYSQQ |
350:
DAQEFLKLLM | ERLHLEINRR | GRRAPPILAS | GPVPSPPRRG | GGALHEEPEL |
400:
SDDDRANLMW | KRYLEREDSK | IVDLFVGQLK | SCLKCQACGY | RSTTFEVFCD |
450:
LSLPIPKKGF | AGGKVSLRDC | FSLFTKEEEL | ESENAPVCDR | CRQKTRSTKK |
500:
LTVQRFPRIL | VLHLNRFSTS | RGSIKKSSVG | VDFPLQRLSL | GDFASDKAGS |
550:
PVYQLYALCN | HSGSVHYGHY | TALCRCQTGW | HVYNDSRVSP | VSENQVASSE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Rat
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Mammary gland .
4.
"Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation."
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Kajitani T.
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,
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,
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,
Ikura T.
,
Muramatsu M.
,
Ito T.
Genes Dev.22:37-49(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF CYS-221; HIS-519 AND ASP-535