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Index > Protein center > Usp21(Gene name) > Mouse
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  • Usp21 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 21 (Protein name ),  UBP21_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Usp21(Usp23);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 21;
    Alternative:
    Ubiquitin thiolesterase 21;Deubiquitinating enzyme 21;Ubiquitin-specific-processing protease 21;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    566
    Sequence:
    50:
    MPQASEHRLG | RTREPPVNVQ | PRVGAKIPFP | PRARSKERRN | PVPGPNSMLR | 
    100:
    PLPPRPGPPD | ERLKKLELGR | GRTSGSRPRG | PLRADHGVPL | PGSPPPAVAL | 
    150:
    PLPSRTNLAR | SKSVSSGDLR | PMGIALGGHR | GAGELGAALS | RLALRPEPPT | 
    200:
    LRRSTSLRRL | GGFPGPPTLL | SIRTEPPTSH | GSFHMISARP | SEPFYSDDKM | 
    250:
    AHHTLLLGSG | HVGLRNLGNT | CFLNAVLQCL | SSTRPLRDFC | LRRDFRQEVP | 
    300:
    GGGRAQELTE | AFADVIGALW | HPDSCEAVNP | TRFRAVFQKY | VPSFSGYSQQ | 
    350:
    DAQEFLKLLM | ERLHLEINRR | GRRAPPILAS | GPVPSPPRRG | GGALHEEPEL | 
    400:
    SDDDRANLMW | KRYLEREDSK | IVDLFVGQLK | SCLKCQACGY | RSTTFEVFCD | 
    450:
    LSLPIPKKGF | AGGKVSLRDC | FSLFTKEEEL | ESENAPVCDR | CRQKTRSTKK | 
    500:
    LTVQRFPRIL | VLHLNRFSTS | RGSIKKSSVG | VDFPLQRLSL | GDFASDKAGS | 
    550:
    PVYQLYALCN | HSGSVHYGHY | TALCRCQTGW | HVYNDSRVSP | VSENQVASSE | 
    566:
    GYVLFYQLMQ | EPLRCL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    Pfam:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 21

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23."
      Smith T.S. , Southan C.
      Biochim. Biophys. Acta1490:184-188(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Mammary gland.
    4. 4.
      "Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation."
      Nakagawa T. , Kajitani T. , Togo S. , Masuko N. , Ohdan H. , Hishikawa Y. , Koji T. , Matsuyama T. , Ikura T. , Muramatsu M. , Ito T.
      Genes Dev.22:37-49(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF CYS-221; HIS-519 AND ASP-535
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