USP28 ELISA Kit for Human(Homo sapiens) | EIAab.comUSP28 ELISA Kit for Human(Homo sapiens)

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USP28 (Gene name),

Ubiquitin carboxyl-terminal hydrolase 28 (Protein name ), UBP28_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

USP28(KIAA1515);

Protein name:

Ubiquitin carboxyl-terminal hydrolase 28;

Alternative:

Ubiquitin thiolesterase 28;Deubiquitinating enzyme 28;Ubiquitin-specific-processing protease 28;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with isoform 1 of FBXW7; following DNA damage, dissociates from FBXW7 leading to degradation of MYC.

Function:

Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus.

Subcellular Location:

Nucleus nucleoplasm

Protein Attributes:

Sequence length:

1077

Sequence:

50:

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950:

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1050:

1077:

PNSPYDLCSR | FAAVMESIQG | VSTVTVK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q96RU2

KEGG:

hsa:57646

UniGene:

Hs.503891

String:

Q96RU2

MIM:

610748

Pfam:

PF00443

STRING:

9606.ENSP00000003302

Uniprot:

Q96RU2

FOR

ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 28

CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 28

Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 28

Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 28

Protein for Human Ubiquitin carboxyl-terminal hydrolase 28

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25."
Valero R. , Bayes M. , Francisca Sanchez-Font M. , Gonzalez-Angulo O. , Gonzalez-Duarte R. , Marfany G.
Genome Biol.2:RESEARCH0043.1-RESEARCH0043.10(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Eye.
6.

"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
DNA Res.7:143-150(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 289-1077 (ISOFORM 2)
tissue: Brain.
7.

"A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response."
Zhang D. , Zaugg K. , Mak T.W. , Elledge S.J.
Cell126:529-542(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TP53BP1;PHOSPHORYLATION AT SER-67 AND SER-714;MUTAGENESIS OF CYS-171
8.

"Fbw7 and Usp28 regulate myc protein stability in response to DNA damage."
Popov N. , Herold S. , Llamazares M. , Schulein C. , Eilers M.
Cell Cycle6:2327-2331(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FBXW7
9.

"The ubiquitin-specific protease USP28 is required for MYC stability."
Popov N. , Wanzel M. , Madiredjo M. , Zhang D. , Beijersbergen R. , Bernards R. , Moll R. , Elledge S.J. , Eilers M.
Nat. Cell Biol.9:765-774(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FBXW7;MUTAGENESIS OF CYS-171
10.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
11.

"The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint."
Bassermann F. , Frescas D. , Guardavaccaro D. , Busino L. , Peschiaroli A. , Pagano M.
Cell134:256-267(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Mechanisms of c-myc degradation by nickel compounds and hypoxia."
Li Q. , Kluz T. , Sun H. , Costa M.
PLoS ONE4:E8531-E8531(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEGRADATION;INDUCTION
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"NMR solution structure of the N-terminal domain of human USP28."
Northeast structural genomics consortium (NESG)
Submitted (2012-07) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-132

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