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Index > Protein center > Usp33(Gene name) > Mouse
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  • Usp33 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 33 (Protein name ),  UBP33_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Usp33(Vdu1);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 33;
    Alternative:
    Ubiquitin thiolesterase 33;Deubiquitinating enzyme 33;VHL-interacting deubiquitinating enzyme 1;Ubiquitin-specific-processing protease 33;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1, ARRB2, ADRB2 and DIO2. Interacts with SELENBP1; in a selenium-dependent manner (By similarity). Interacts with ROBO1.
    Function:
    Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Also involved in breast cancer cell migration by regulating Slit responsiveness. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
    Subcellular Location:
    Cytoplasm perinuclear region
    Protein Attributes:
    Sequence length:
    909
    Sequence:
    50:
    MTTFRNHCPH | LDSVGEITKE | DLIQKSLGAC | QDCKVRGPNL | WACLENRCSY | 
    100:
    VGCGESQVDH | STIHSQETKH | YLTVNLTTLR | VWCYACSKEV | FLDRKLGTPP | 
    150:
    SLPHVRQPQQ | TQENSVQDFK | IPSNPALKTP | MVAVSEDLDI | EVEEEDELKA | 
    200:
    RGLTGLKNIG | NTCYMNAALQ | ALSNCPPLTQ | FFLDCGGLAR | TDKKPAICKS | 
    250:
    YLKLMTELWH | KSRPGSVVPA | NLFQGIKTVN | PTFRGYSQQD | AQEFLRCLMD | 
    300:
    LLHEELKEQV | MEMEEEPQTL | TSEETVEEEK | SQSDVDFQSC | ESCSSSEKAE | 
    350:
    NESGSKGFPE | DSNETTMLIQ | DEDDLEMAKD | WQKEKVCNKI | NKANADVELD | 
    400:
    KDRDTVCETV | DLNSQETVKV | QIHGRASESI | TDVHLNDLAT | SQILPSNESV | 
    450:
    SPRLSASPPK | LGSLWPGLSP | PHKKAQSTSA | KRKKQHKKYR | SVISDIFDGT | 
    500:
    VISSVQCLTC | DRVSITLETF | QDLSLPIPGK | EDLAKLHSSS | HPTIVKAGSC | 
    550:
    GEAYAPQGWI | AFFMEYVKRF | VVSCVPSWFW | GPVVTLQDCL | AAFFARDELK | 
    600:
    GDNMYSCEKC | KKLRNGVKFC | KVQKFPEILC | IHLKRFRHEL | MFSTKISTHV | 
    650:
    SFPLEGLDLQ | PFLAKDSPAQ | IVTYDLLSVI | CHHGTASSGH | YIAYCRNNLN | 
    700:
    NLWYEFDDQS | VTEVSESTVQ | NAEAYVLFYR | KSSEEAQKER | RRISNLLNIM | 
    750:
    EPSLLQFYIS | RQWLNKFKTF | AEPGPISNND | FLCIHGGIPP | RKASYIEDLV | 
    800:
    LMLPQNIWDN | LYSRYGGGPA | VNHLYICHTC | QIELEKIEKR | RKTELEIFIR | 
    850:
    LNRAFQEEDS | PATFYCISMQ | WFREWESFVK | GKDGDPPGPI | DNTKIAVTKC | 
    900:
    GSVMLKQGAD | SGQISEETWN | FLQSIYGGGP | EVILRPPVVH | VDPDVLQAEE | 
    909:
    KIEVETRSL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 33
    Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 33

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein."
      Li Z. , Na X. , Wang D. , Schoen S.R. , Messing E.M. , Wu G.
      J. Biol. Chem.277:4656-4662(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-909 (ISOFORM 1)
      strain: C57BL/6.
      strain: FVB/N.
      tissue: Brain.
      tissue: Eye.
      tissue: Mammary tumor.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-880 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Spleen.
    4. 4.
      "Midline crossing and Slit responsiveness of commissural axons require USP33."
      Yuasa-Kawada J. , Kinoshita-Kawada M. , Wu G. , Rao Y. , Wu J.Y.
      Nat. Neurosci.12:1087-1089(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ROBO1;TISSUE SPECIFICITY
    5. 5.
      "Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration."
      Yuasa-Kawada J. , Kinoshita-Kawada M. , Rao Y. , Wu J.Y.
      Proc. Natl. Acad. Sci. U.S.A.106:14530-14535(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ROBO1
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