Protein name:
Ubiquitin carboxyl-terminal hydrolase 33 ;
Alternative:
Ubiquitin thiolesterase 33 ;Deubiquitinating enzyme 33 ;VHL-interacting deubiquitinating enzyme 1 ;Ubiquitin-specific-processing protease 33 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with VHL, leading to its ubiquitination and subsequent degradation. Interacts with ARRB1, ARRB2, ADRB2 and DIO2. Interacts with SELENBP1; in a selenium-dependent manner (By similarity). Interacts with ROBO1.
Function:
Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Also involved in breast cancer cell migration by regulating Slit responsiveness. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.
Subcellular Location:
Cytoplasm
perinuclear region
Protein Attributes:
50:
MTTFRNHCPH | LDSVGEITKE | DLIQKSLGAC | QDCKVRGPNL | WACLENRCSY |
100:
VGCGESQVDH | STIHSQETKH | YLTVNLTTLR | VWCYACSKEV | FLDRKLGTPP |
150:
SLPHVRQPQQ | TQENSVQDFK | IPSNPALKTP | MVAVSEDLDI | EVEEEDELKA |
200:
RGLTGLKNIG | NTCYMNAALQ | ALSNCPPLTQ | FFLDCGGLAR | TDKKPAICKS |
250:
YLKLMTELWH | KSRPGSVVPA | NLFQGIKTVN | PTFRGYSQQD | AQEFLRCLMD |
300:
LLHEELKEQV | MEMEEEPQTL | TSEETVEEEK | SQSDVDFQSC | ESCSSSEKAE |
350:
NESGSKGFPE | DSNETTMLIQ | DEDDLEMAKD | WQKEKVCNKI | NKANADVELD |
400:
KDRDTVCETV | DLNSQETVKV | QIHGRASESI | TDVHLNDLAT | SQILPSNESV |
450:
SPRLSASPPK | LGSLWPGLSP | PHKKAQSTSA | KRKKQHKKYR | SVISDIFDGT |
500:
VISSVQCLTC | DRVSITLETF | QDLSLPIPGK | EDLAKLHSSS | HPTIVKAGSC |
550:
GEAYAPQGWI | AFFMEYVKRF | VVSCVPSWFW | GPVVTLQDCL | AAFFARDELK |
600:
GDNMYSCEKC | KKLRNGVKFC | KVQKFPEILC | IHLKRFRHEL | MFSTKISTHV |
650:
SFPLEGLDLQ | PFLAKDSPAQ | IVTYDLLSVI | CHHGTASSGH | YIAYCRNNLN |
700:
NLWYEFDDQS | VTEVSESTVQ | NAEAYVLFYR | KSSEEAQKER | RRISNLLNIM |
750:
EPSLLQFYIS | RQWLNKFKTF | AEPGPISNND | FLCIHGGIPP | RKASYIEDLV |
800:
LMLPQNIWDN | LYSRYGGGPA | VNHLYICHTC | QIELEKIEKR | RKTELEIFIR |
850:
LNRAFQEEDS | PATFYCISMQ | WFREWESFVK | GKDGDPPGPI | DNTKIAVTKC |
900:
GSVMLKQGAD | SGQISEETWN | FLQSIYGGGP | EVILRPPVVH | VDPDVLQAEE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
ELISA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
CLIA Kit for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Polyclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Monoclonal Antibody for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 33
Protein for Mouse Ubiquitin carboxyl-terminal hydrolase 33
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 225-909 (ISOFORM 1)
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C57BL/6 .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-880 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Spleen .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ROBO1;TISSUE SPECIFICITY
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ROBO1