Protein name:
Ubiquitin carboxyl-terminal hydrolase 37 ;
Alternative:
Ubiquitin thiolesterase 37 ;Deubiquitinating enzyme 37 ;Ubiquitin-specific-processing protease 37 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts with FZR1/CDH1.
Function:
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
Subcellular Location:
N/A
Protein Attributes:
50:
MSPLKIHGPI | RIRSMQTGIT | KWKEGSFEVV | EKENKVSLVV | HYNTGGIPRI |
100:
FQLSHNIKNV | VLRPSGAKQS | RLMLTLQDNS | FLSIDKVPSK | DAEEMRLFLD |
150:
AVHQNRLNAA | MKPSQGSGSF | GAILGSRTSQ | KETNRQLSYS | DNQVSSKRGS |
200:
LETKDDTPFR | KVLGNPSRGS | IKAAAGNGVT | PARTIPSLTS | TSTPLRSGLL |
250:
ENRTEKRKRM | LSSGSELNED | YPKENDSSSN | NKAMTDPSRK | YLTSSREKQL |
300:
SLKQSEENRT | SGLLPLQSSS | FYGSRTAAKD | YSPGSTNLDR | TNISSQTPSA |
350:
KRSLGFLPQP | APLSVKKLRC | NQDYTGWNKP | RVPLSSHQQQ | QLQGFSNLGN |
400:
TCYMNAILQS | LFSLQSFAND | LLKQGIPWKK | IPLNALIRRF | AHLLVKKDIC |
450:
NSETKKDLLK | KVKNAISATA | ERFSGYMQND | AHEFLSQCLD | QLKEDMEKLN |
500:
KTWKIEPVPG | EENSPDISAT | RVYTCPVITN | LEFEVQHSII | CKVCGEIIPK |
550:
REQFNDLSID | LPRRKKPLPP | RSIQDSLDLF | FRAEELEYSC | EKCGGKCALV |
600:
RHKFNRLPRI | LILHLKRYSF | NVALSLNNKI | GQQVIIPRYL | TLSSHCTENT |
650:
KPPFNLGWSA | QMAVSRPLKA | SQMVNSCITS | PSTPSKNFTF | KSKTSLALSL |
700:
DSDSEDELKR | SVALSHRLCE | MSGSEQQQED | LEKDSKSCRI | EPDKSELENS |
750:
GFDGMSEEEL | LAAVLEISKR | EASPSLSHED | DDKPTSSPDT | GFAEDDIQEM |
800:
PENPDSVETE | KPKTITEPDP | ASFTEITKDC | DENKENKTPE | GSQGEVDWLQ |
850:
QYDMEREREE | QELQQALAQS | LQEQEAWEQK | EDDDLKRATE | LSLQEFNNSF |
900:
VDSLGSDEDS | GNEDVLDMEY | TEAEAEELKR | NAETGNLPHS | YRLISVVSHI |
950:
GSTSSSGHYI | SDVYDIKKQA | WFTYNDLEVS | KIQEASVQSD | RDRSGYIFFY |
981:
MHKEIFDELL | ETEKNSQALN | LEVGKTTRQV | S
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Dog
Pig
Chicken
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
ELISA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
CLIA Kit for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Polyclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Monoclonal Antibody for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 37
Protein for Bovine Ubiquitin carboxyl-terminal hydrolase 37
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]