Protein name:
UBX domain-containing protein 1 ;
Alternative:
SAPK substrate protein 1 ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2 (By similarity). Interacts directly with VCP. Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated bur is strongly enhanced in the presence of autoubiquitinated BRCA1.
Function:
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MAELTALESL | IEMGFPKGRA | EKALALTGNQ | GIEAAMDWLM | EHEDDPDVDE |
100:
PLATPLGHVL | GREPTPSEQG | GPKGPGSAVG | EGKPVLTEEE | RQEQTKRMLE |
150:
LVAQKQRERE | EREEREALER | ERQRRRQGQE | LTAARQRLQE | DEMRRAAEER |
200:
RREKAEELEA | RQRVREKIER | DKAERAKKYG | GNVGSQPSPP | ATEPGPVPSS |
250:
PSREPPTKRE | YDQCRIQVRL | PDGTSLTQTF | RAREQLAAVR | LYVELHRGEE |
297:
LGGAQDPVQL | LSGFPRRAFS | EADMERPLQE | LGLVPSAVLI | VAKKCPG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
ELISA Kit for Bovine UBX domain-containing protein 1
ELISA Kit for Bovine UBX domain-containing protein 1
ELISA Kit for Bovine UBX domain-containing protein 1
ELISA Kit for Bovine UBX domain-containing protein 1
CLIA Kit for Bovine UBX domain-containing protein 1
CLIA Kit for Bovine UBX domain-containing protein 1
CLIA Kit for Bovine UBX domain-containing protein 1
CLIA Kit for Bovine UBX domain-containing protein 1
Polyclonal Antibody for Bovine UBX domain-containing protein 1
Polyclonal Antibody for Bovine UBX domain-containing protein 1
Polyclonal Antibody for Bovine UBX domain-containing protein 1
Polyclonal Antibody for Bovine UBX domain-containing protein 1
Monoclonal Antibody for Bovine UBX domain-containing protein 1
Monoclonal Antibody for Bovine UBX domain-containing protein 1
Monoclonal Antibody for Bovine UBX domain-containing protein 1
Monoclonal Antibody for Bovine UBX domain-containing protein 1
Protein for Bovine UBX domain-containing protein 1
Protein for Bovine UBX domain-containing protein 1
Protein for Bovine UBX domain-containing protein 1
Protein for Bovine UBX domain-containing protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Crossbred X Angus .
tissue :
Liver .