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Index > Protein center > Ubxn1(Gene name) > Mouse
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  • Ubxn1 (Gene name),
  • UBX domain-containing protein 1 (Protein name ),  UBXN1_MOUSE from NCBI database.
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  • Gene name:
    Ubxn1(D19Ertd721e;Saks1);
    Protein name:
    UBX domain-containing protein 1;
    Alternative:
    SAPK substrate protein 1;Protein 2B28;UBA/UBX 33.3 kDa protein(mY33K);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with BRCA1 and BARD1; interaction takes place when BRCA1 is not autoubiquitinated bur is strongly enhanced in the presence of autoubiquitinated BRCA1 (By similarity). Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Interacts with HOMER2. Interacts directly with VCP.
    Function:
    Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer (By similarity) Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Involved in ubiquitin-proteasome systems.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    297
    Sequence:
    50:
    MAELTALESL | IEMGFPRGRA | EKALALTGNQ | GIEAAMDWLM | EHEDDPDVDE | 
    100:
    PLETPLSHVL | GREPTPSEQV | GPEGSGSAAG | ESRPILTEEE | RQEQTKRMLE | 
    150:
    LVAQKQRERE | EREEREALER | EKQRRRQGQE | LSVARQKLQE | DEMRRAAEER | 
    200:
    RREKAEELAA | RQRVREKIER | DKAERAKKYG | GSVGSRSSPP | ATDPGPVPSS | 
    250:
    PSQEPPTKRE | YDQCRIQVRL | PDGTSLTQTF | RAREQLAAVR | LYVELHRGEE | 
    297:
    PGQDQDPVQL | LSGFPRRAFS | EADMERPLQE | LGLVPSAVLI | VAKKCPS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    E6426h
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    Packing:
    96T
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    ELISA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    E6426r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    E6426b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    E6426m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    U6426b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    U6426m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    U6426h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse UBX domain-containing protein 1
    Cat.:
    U6426r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse UBX domain-containing protein 1
    Cat.:
    P6426Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse UBX domain-containing protein 1
    Cat.:
    P6426Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse UBX domain-containing protein 1
    Polyclonal Antibody for Mouse UBX domain-containing protein 1
    Cat.:
    P6426Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse UBX domain-containing protein 1
    Monoclonal Antibody for Mouse UBX domain-containing protein 1
    Monoclonal Antibody for Mouse UBX domain-containing protein 1
    Monoclonal Antibody for Mouse UBX domain-containing protein 1
    Protein for Mouse UBX domain-containing protein 1
    Protein for Mouse UBX domain-containing protein 1
    Protein for Mouse UBX domain-containing protein 1
    Protein for Mouse UBX domain-containing protein 1

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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Bone marrow.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation."
      Park H. , Suzuki T. , Lennarz W.J.
      Proc. Natl. Acad. Sci. U.S.A.98:11163-11168(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGLY1
    4. 4.
      "Phosphoproteomic analysis of the developing mouse brain."
      Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
      Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic brain.
    5. 5.
      "A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems."
      Ishibashi T. , Ogawa S. , Hashiguchi Y. , Inoue Y. , Udo H. , Ohzono H. , Kato A. , Minakami R. , Sugiyama H.
      J. Biochem.137:617-623(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH HOMER2
    6. 6.
      "The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor."
      Li G. , Zhao G. , Zhou X. , Schindelin H. , Lennarz W.J.
      Proc. Natl. Acad. Sci. U.S.A.103:8348-8353(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AMFR; NGLY1; RAD23B AND VCP
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    9. 9.
      "Solution structure of RSGI RUH-027, a UBA domain from mouse cDNA."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 2-52
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