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Index > Protein center > Uchl1(Gene name) > Mouse
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  • Uchl1 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase isozyme L1 (Protein name ),  UCHL1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Uchl1;
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L1(UCH-L1);
    Alternative:
    PGP 9.5(PGP9.5);Neuron cytoplasmic protein 9.5;Ubiquitin thioesterase L1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer. Interacts with COPS5 and SNCA.
    Function:
    Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    223
    Sequence:
    50:
    MQLKPMEINP | EMLNKVLAKL | GVAGQWRFAD | VLGLEEETLG | SVPSPACALL | 
    100:
    LLFPLTAQHE | NFRKKQIEEL | KGQEVSPKVY | FMKQTIGNSC | GTIGLIHAVA | 
    150:
    NNQDKLEFED | GSVLKQFLSE | TEKLSPEDRA | KCFEKNEAIQ | AAHDSVAQEG | 
    200:
    QCRVDDKVNF | HFILFNNVDG | HLYELDGRMP | FPVNHGASSE | DSLLQDAAKV | 
    223:
    CREFTEREQG | EVRFSAVALC | KAA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse UCH-L1
    Cat.:
    E1741h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse UCH-L1
    Cat.:
    E1741p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse UCH-L1
    Cat.:
    E1741r
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse UCH-L1
    Cat.:
    E1741m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse UCH-L1
    Cat.:
    E1741b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse UCH-L1
    Cat.:
    U1741r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse UCH-L1
    Cat.:
    U1741p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse UCH-L1
    Cat.:
    U1741b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse UCH-L1
    Cat.:
    U1741m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse UCH-L1
    Cat.:
    U1741h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse UCH-L1
    Cat.:
    P1741Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse UCH-L1
    Polyclonal Antibody for Mouse UCH-L1
    Polyclonal Antibody for Mouse UCH-L1
    Cat.:
    P1741Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse UCH-L1
    Cat.:
    P1741Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse UCH-L1
    Monoclonal Antibody for Mouse UCH-L1
    Monoclonal Antibody for Mouse UCH-L1
    Monoclonal Antibody for Mouse UCH-L1
    Monoclonal Antibody for Mouse UCH-L1
    Protein for Mouse UCH-L1
    Protein for Mouse UCH-L1
    Protein for Mouse UCH-L1
    Protein for Mouse UCH-L1
    Protein for Mouse UCH-L1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice."
      Saigoh K. , Wang Y.-L. , Suh J.G. , Yamanishi T. , Sakai Y. , Kiyosawa H. , Harada T. , Ichihara N. , Wakana S. , Kikuchi T. , Wada K.
      Nat. Genet.23:47-51(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
      tissue: Brain.
    2. 2.
      "Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries."
      Marzban G. , Grillari J. , Reisinger E. , Hemetsberger T. , Grabherr R. , Katinger H.
      Exp. Gerontol.37:1451-1460(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 1-10;TISSUE SPECIFICITY
      strain: C57BL/6J.
      tissue: Pituitary.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Hippocampus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Retina.
    5. 5.
      Lubec G. , Kang S.U. , Klug S. , Yang J.W. , Zigmond M.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-27; 66-78; 116-123; 136-153 AND 158-199;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
      tissue: Hippocampus.
    6. 6.
      "Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron."
      Osaka H. , Wang Y.-L. , Takada K. , Takizawa S. , Setsuie R. , Li H. , Sato Y. , Nishikawa K. , Sun Y.-J. , Sakurai M. , Harada T. , Hara Y. , Kimura I. , Chiba S. , Namikawa K. , Kiyama H. , Noda M. , Aoki S. , more...
      Hum. Mol. Genet.12:1945-1958(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;MUTAGENESIS OF ASP-30 AND CYS-90;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo."
      Harada T. , Harada C. , Wang Y.-L. , Osaka H. , Amanai K. , Tanaka K. , Takizawa S. , Setsuie R. , Sakurai M. , Sato Y. , Noda M. , Wada K.
      Am. J. Pathol.164:59-64(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels."
      Lombardino A.J. , Li X.-C. , Hertel M. , Nottebohm F.
      Proc. Natl. Acad. Sci. U.S.A.102:8036-8041(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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