Uchl3 ELISA Kit for Mouse(Mus musculus) | EIAab.comUchl3 ELISA Kit for Mouse(Mus musculus)

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Uchl3 (Gene name),

Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Protein name ), UCHL3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Uchl3;

Protein name:

Ubiquitin carboxyl-terminal hydrolase isozyme L3(UCH-L3);

Alternative:

Ubiquitin thioesterase L3;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.

Function:

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

230

Sequence:

50:

100:

150:

200:

230:

LLEDAIEVCK | KFMERDPDEL | RFNAIALSAA |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9JKB1

KEGG:

mmu:50933

String:

Q9JKB1

UniGene:

Mm.275970

Pfam:

PF01088

Uniprot:

Q9JKB1

FOR

ELISA Kit for Mouse UCH-L3

CLIA Kit for Mouse UCH-L3

Polyclonal Antibody for Mouse UCH-L3

Monoclonal Antibody for Mouse UCH-L3

Protein for Mouse UCH-L3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression and functional analysis of Uch-L3 during mouse development."
Kurihara L.J. , Semenova E. , Levorse J.M. , Tilghman S.M.
Mol. Cell. Biol.20:2498-2504(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
strain: Swiss Webster / NIH.
2.

"Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3."
Osawa Y. , Wang Y.-L. , Osaka H. , Aoki S. , Wada K.
Biochem. Biophys. Res. Commun.283:627-633(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: C57BL/6J.
tissue: Kidney.
tissue: Liver.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
4.

"Cleavage of the C-terminus of NEDD8 by UCH-L3."
Wada H. , Kito K. , Caskey L.S. , Yeh E.T.H. , Kamitani T.
Biochem. Biophys. Res. Commun.251:688-692(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
5.

"Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory."
Wood M.A. , Kaplan M.P. , Brensinger C.M. , Guo W. , Abel T.
Hippocampus15:610-621(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
6.

"Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice."
Sano Y. , Furuta A. , Setsuie R. , Kikuchi H. , Wang Y.L. , Sakurai M. , Kwon J. , Noda M. , Wada K.
Am. J. Pathol.169:132-141(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
7.

"The new function of two ubiquitin C-terminal hydrolase isozymes as reciprocal modulators of germ cell apoptosis."
Kwon J.
Exp. Anim.56:71-77(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;TISSUE SPECIFICITY
8.

"The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel."
Butterworth M.B. , Edinger R.S. , Ovaa H. , Burg D. , Johnson J.P. , Frizzell R.A.
J. Biol. Chem.282:37885-37893(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENAC RECYCLING;SUBCELLULAR LOCATION
9.

"Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis."
Suzuki M. , Setsuie R. , Wada K.
Endocrinology150:5230-5239(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN ADIPOGENESIS AND INSULIN SIGNALING;MUTAGENESIS OF CYS-95
10.

"Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses."
Setsuie R. , Suzuki M. , Tsuchiya Y. , Wada K.
Neurochem. Int.56:911-918(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
11.

"Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)."
Dennissen F.J. , Kholod N. , Hermes D.J. , Kemmerling N. , Steinbusch H.W. , Dantuma N.P. , van Leeuwen F.W.
FEBS Lett.585:2568-2574(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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