Protein name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) ;
Alternative:
Ubiquitin thioesterase L3 ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Preferentially binds diubiquitin; the interaction does not hydrolyze diubiquitin but, in vitro, inhibits the hydrolyzing activity on other substrates.
Function:
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MEGQRWLPLE | ANPEVTNQFL | KQLGLHPNWQ | FVDVYGMDPE | LLSMVPRPVC |
100:
AVLLLFPITE | KYEVFRTEEE | EKIKSQGQDV | TPSVYFMKQT | ISNACGTIGL |
150:
IHAIANNKNK | MHFESGSTLK | KFLEESASMS | PDERARYLES | YDAIPVTHET |
200:
SAHEGQTEAP | NIDEKVDLHF | IALVHVDGHL | YELDGRKPFP | INHGETSDET |
230:
LLEDAIEVCK | KFMERDPDEL | RFNAIALSAA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Rat
Bovine
Mouse
Polyclonal Antibody for Pig UCH-L3
Polyclonal Antibody for Pig UCH-L3
Polyclonal Antibody for Pig UCH-L3
Polyclonal Antibody for Pig UCH-L3
Polyclonal Antibody for Pig UCH-L3
Monoclonal Antibody for Pig UCH-L3
Monoclonal Antibody for Pig UCH-L3
Monoclonal Antibody for Pig UCH-L3
Monoclonal Antibody for Pig UCH-L3
Monoclonal Antibody for Pig UCH-L3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
Liu G.Y.
Submitted (2006-08) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]