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Index > Protein center > Uchl5(Gene name) > Mouse
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  • Uchl5 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase isozyme L5 (Protein name ),  UCHL5_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Uchl5(Uch37);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase isozyme L5(UCH-L5);
    Alternative:
    Ubiquitin thioesterase L5;Ubiquitin C-terminal hydrolase UCH37;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Component of the 19S (PA700) regulatory complex of the 26S proteasome. Interacts with ADRM1 and NFRKB. Component of the INO80 complex; specifically part of a complex module associated with N-terminus of INO80.
    Function:
    Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.
    Subcellular Location:
    Cytoplasm Nucleus Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus.
    Protein Attributes:
    Sequence length:
    329
    Sequence:
    50:
    MSSNAGEWCL | MESDPGVFTE | LIKGFGCRGA | QVEEIWSLEP | ESFEKLKPVH | 
    100:
    GLIFLFKWQP | GEEPAGSVVQ | DSRLETIFFA | KQVINNACAT | QAIVSVLLNC | 
    150:
    THQDVHLGET | LSEFKEFSQS | FDAAMKGLAL | SNSDVIRQVH | NSFARQQMFE | 
    200:
    FDTKTPAKEE | DAFHFVSYVP | VNGRLYELDG | LREGPIDLGA | CNQDDWITAV | 
    250:
    RPVIEKRIQK | YSEGEIRFNL | MAIVSDRKMI | YEQKIAELQR | QLAEEEPMDT | 
    300:
    DQGSTVLSAI | QSEVARNQML | IEEEVQKLKR | YKIENIRRKH | NYLPFIMELL | 
    329:
    KTLAEHQQLI | PLVEKAKEKQ | NAKKAQETK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse UCH-L5
    ELISA Kit for Mouse UCH-L5
    ELISA Kit for Mouse UCH-L5
    ELISA Kit for Mouse UCH-L5
    CLIA Kit for Mouse UCH-L5
    CLIA Kit for Mouse UCH-L5
    CLIA Kit for Mouse UCH-L5
    CLIA Kit for Mouse UCH-L5
    Polyclonal Antibody for Mouse UCH-L5
    Polyclonal Antibody for Mouse UCH-L5
    Polyclonal Antibody for Mouse UCH-L5
    Polyclonal Antibody for Mouse UCH-L5
    Monoclonal Antibody for Mouse UCH-L5
    Monoclonal Antibody for Mouse UCH-L5
    Monoclonal Antibody for Mouse UCH-L5
    Monoclonal Antibody for Mouse UCH-L5
    Protein for Mouse UCH-L5
    Protein for Mouse UCH-L5
    Protein for Mouse UCH-L5
    Protein for Mouse UCH-L5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      Xu W. , DeMartino G.N. , Slaughter C.A. , Cohen R.E.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Identification of a novel mouse ubiquitin C-terminal hydrolase: cloning, expression and functional characterization."
      Li T.W. , Sun B. , Mustafa F.B. , Lee M.K. , Teo T.S.
      Submitted (1999-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Embryonic liver.
      tissue: Pancreas.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: Czech II.
      tissue: Mammary gland.
    5. 5.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-158;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-47 AND LYS-289;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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