UGT1A8 ELISA Kit for Human(Homo sapiens) | EIAab.comUGT1A8 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > UGT1A8(Gene name) > Human

UGT1A8 (Gene name),

UDP-glucuronosyltransferase 1-8 (Protein name ), UD18_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

UGT1A8(GNT1;UGT1);

Protein name:

UDP-glucuronosyltransferase 1-8(UDPGT 1-8;UGT1*8;UGT1-08;UGT1.8);

Alternative:

UDP-glucuronosyltransferase 1A8;UDP-glucuronosyltransferase 1-H(UGT-1H;UGT1H);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Subcellular Location:

Microsome Endoplasmic reticulum membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

530

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

530:

FITFKCCAYG | YRKCLGKKGR | VKKAHKSKTH |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.554822

MIM:

191740

STRING:

9606.ENSP00000362549

SMR:

Q9HAW9

Pfam:

PF00201

String:

Q9HAW9

KEGG:

hsa:54576

Uniprot:

Q9HAW9

FOR

ELISA Kit for Human UDPGT 1-8

CLIA Kit for Human UDPGT 1-8

Polyclonal Antibody for Human UDPGT 1-8

Monoclonal Antibody for Human UDPGT 1-8

Protein for Human UDPGT 1-8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8."
Strassburg C.P. , Manns M.P. , Tukey R.H.
J. Biol. Chem.273:8719-8726(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS ARG-132; ALA-154; GLY-173; ALA-202 AND LEU-212
2.

"Thirteen UDP-glucuronosyltransferase genes are encoded at the human UGT1 gene complex locus."
Gong Q.H. , Cho J.W. , Huang T. , Potter C. , Gholami N. , Basu N.K. , Kubota S. , Carvalho S. , Pennington M.W. , Owens I.S. , Popescu N.C.
Pharmacogenetics11:357-368(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3."
Huang Y.-H. , Galijatovic A. , Nguyen N. , Geske D. , Beaton D. , Green J. , Green M. , Peters W.H. , Tukey R.H.
Pharmacogenetics12:287-297(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS GLY-173 AND TYR-277
tissue: Colon.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-173
tissue: Tongue.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Identification of genetic polymorphisms within the human extrahepatic UGT1A8 gene."
Strassburg C.P. , Vogel A. , Manns M.P.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-285;VARIANTS ARG-132; ALA-154; GLY-173; ALA-202 AND LEU-212
7.

Guillemette C. , Levesque E. , Girard H. , Bernard O.
Submitted (2006-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
8.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-292 AND ASN-344
tissue: Liver.
9.

"Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity."
Girard H. , Levesque E. , Bellemare J. , Journault K. , Caillier B. , Guillemette C.
Pharmacogenet. Genomics17:1077-1089(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 2);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
10.

"Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones."
Tang L. , Singh R. , Liu Z. , Hu M.
Mol. Pharm.6:1466-1482(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro."
Bellemare J. , Rouleau M. , Girard H. , Harvey M. , Guillemette C.
Drug Metab. Dispos.38:1785-1789(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION (ISOFORM 2);SUBUNIT
12.

"Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population."
Menard V. , Girard H. , Harvey M. , Perusse L. , Guillemette C.
Hum. Mutat.30:677-687(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VAL-144; GLY-173; THR-231 AND TYR-277

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