UGT2B4 ELISA Kit for Human(Homo sapiens) | EIAab.comUGT2B4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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UGT2B4 (Gene name),

UDP-glucuronosyltransferase 2B4 (Protein name ), UD2B4_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

UGT2B4(UGT2B11);

Protein name:

UDP-glucuronosyltransferase 2B4(UDPGT 2B4);

Alternative:

Hyodeoxycholic acid-specific UDPGT;HLUG25;UDPGTh-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Subcellular Location:

Microsome membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

528

Sequence:

50:

MSMKWTSALL | LIQLSCYFSS | GSCGKVLVWP | TEFSHWMNIK | TILDELVQRG |

100:

HEVTVLASSA | SISFDPNSPS | TLKFEVYPVS | LTKTEFEDII | KQLVKRWAEL |

150:

PKDTFWSYFS | QVQEIMWTFN | DILRKFCKDI | VSNKKLMKKL | QESRFDVVLA |

200:

DAVFPFGELL | AELLKIPFVY | SLRFSPGYAI | EKHSGGLLFP | PSYVPVVMSE |

250:

LSDQMTFIER | VKNMIYVLYF | EFWFQIFDMK | KWDQFYSEVL | GRPTTLSETM |

300:

AKADIWLIRN | YWDFQFPHPL | LPNVEFVGGL | HCKPAKPLPK | EMEEFVQSSG |

350:

ENGVVVFSLG | SMVSNTSEER | ANVIASALAK | IPQKVLWRFD | GNKPDTLGLN |

400:

TRLYKWIPQN | DLLGHPKTRA | FITHGGANGI | YEAIYHGIPM | VGVPLFADQP |

450:

DNIAHMKAKG | AAVSLDFHTM | SSTDLLNALK | TVINDPLYKE | NAMKLSRIHH |

500:

DQPVKPLDRA | VFWIEFVMRH | KGAKHLRVAA | HDLTWFQYHS | LDVTGFLLAC |

528:

VATVIFIITK | CLFCVWKFVR | TGKKGKRD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

KEGG:

UniGene:

Pfam:

String:

STRING:

9606.ENSP00000305221

MIM:

Uniprot:

FOR

ELISA Kit for Human UDPGT 2B4

CLIA Kit for Human UDPGT 2B4

Polyclonal Antibody for Human UDPGT 2B4

Monoclonal Antibody for Human UDPGT 2B4

Protein for Human UDPGT 2B4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA."
Jackson M.R. , McCarthy L.R. , Harding D. , Wilson S. , Coughtrie M.W.H. , Burchell B.
Biochem. J.242:581-588(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
2.

"cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily."
Jin C.-J. , Miners J.O. , Lillywhite K.J. , McKenzie P.I.
Biochem. Biophys. Res. Commun.194:496-503(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Liver.
3.

"Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene."
Levesque E. , Beaulieu M. , Hum D.W. , Belanger A.
Pharmacogenetics9:207-216(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLU-458;CHARACTERIZATION
4.

McKenzie P.I.
Submitted (1998-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS LEU-109 AND LEU-396
5.

"Genomic organization and structure of the UGT2B gene complex at human chromosome 4q13."
Riedy M. , Miller A.
Submitted (1999-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

Shen C. , Ke R. , Wang C. , Li H. , Zhou G. , Zhong G. , Lin L. , Yang S.
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
7.

NIEHS SNPs program
Submitted (2006-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ASN-40; THR-78; PRO-80; ILE-277; GLU-458 AND ARG-511
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Liver.
tissue: Pericardium.
9.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Liver.
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-315
tissue: Liver.

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