Protein name:
Ubiquitin fusion degradation protein 1 homolog (UB fusion protein 1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion.
Function:
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
Subcellular Location:
Nucleus
Cytoplasm
cytosol
Protein Attributes:
50:
MFSFNMFDHP | IPRVFQNRFS | TQYRCFSVSM | LAGPNDRSDV | EKGGKIIMPP |
100:
SALDQLSRLN | ITYPMLFKLT | NKNSDRMTHC | GVLEFVADEG | ICYLPHWMMQ |
150:
NLLLEEGGLV | QVESVNLQVA | TYSKFQPQSP | DFLDITNPKA | VLENALRNFA |
200:
CLTTGDVIAI | NYNEKIYELR | VMETKPDKAV | SIIECDMNVD | FDAPLGYKEP |
250:
ERQVQHEEST | EGEADHSGYA | GELGFRAFSG | SGNRLDGKKK | GVEPSPSPIK |
300:
PGDIKRGIPN | YEFKLGKITF | IRNSRPLVKK | VEEDEAGGRF | VAFSGEGQSL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human UB fusion protein 1
ELISA Kit for Human UB fusion protein 1
ELISA Kit for Human UB fusion protein 1
CLIA Kit for Human UB fusion protein 1
CLIA Kit for Human UB fusion protein 1
CLIA Kit for Human UB fusion protein 1
Polyclonal Antibody for Human UB fusion protein 1
Polyclonal Antibody for Human UB fusion protein 1
Polyclonal Antibody for Human UB fusion protein 1
Monoclonal Antibody for Human UB fusion protein 1
Monoclonal Antibody for Human UB fusion protein 1
Monoclonal Antibody for Human UB fusion protein 1
Protein for Human UB fusion protein 1
Protein for Human UB fusion protein 1
Protein for Human UB fusion protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT);VARIANT ALA-130
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
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Heart .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
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more...
Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
tissue :
Brain .
tissue :
Skin .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NPLOC4
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231; SER-245; SER-247 AND SER-299;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH USP13
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-299;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 11-193