Tyrosine-protein kinase receptor UFO (Protein name
), UFO_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
AXL(UFO);
Protein name:
Tyrosine-protein kinase receptor UFO;
Alternative:
AXL oncogene;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer and heterotetramer with ligand GAS6. Interacts with CBL, GRB2, LCK, NCK2, PIK3R1, PIK3R2, PIK3R3, PLCG1, SOCS1 and TENC1.
Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitement of GRB2 and phosphatidylinositol-3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANT ASP-266;ROLE IN MYELOID LEUKEMIA
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANT ASP-266
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANT ASP-266
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 677-730;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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Cited for: PHOSPHORYLATION AT TYR-779; TYR-821 AND TYR-866;INTERACTION WITH GRB2; LCK; PIK3R1; PIK3R2 AND PLCG1
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Cited for: FUNCTION IN PLATELET ACTIVATION AND THROMBOTIC RESPONSE REGULATION
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Cited for: FUNCTION AS CELL ENTRY FACTOR IN FILOVIRUS INFECTION
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Cited for: INTERACTION WITH GRB2; PIK3R1 AND PIK3R2;PHOSPHORYLATION AT TYR-779; TYR-821 AND TYR-866
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-884;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 33-227 IN COMPLEX WITH GAS6;MUTAGENESIS OF GLU-63; GLU-66 AND THR-84;SUBUNIT
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Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-112; TRP-295; CYS-499 AND GLY-515
Vaild Sequence:
