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Index > Protein center > Uhrf2(Gene name) > Mouse
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  • Uhrf2 (Gene name),
  • E3 ubiquitin-protein ligase UHRF2 (Protein name ),  UHRF2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Uhrf2(Nirf);
    Protein name:
    E3 ubiquitin-protein ligase UHRF2;
    Alternative:
    Np95-like ring finger protein;NIRF;Nuclear zinc finger protein Np97;Nuclear protein 97;Ubiquitin-like-containing PHD and RING finger domains protein 2;Ubiquitin-like PHD and RING finger domain-containing protein 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds methylated CpG containing oligonucleotides. Interacts with PCNP, HDAC1 and inactive CDK2. Component of a complex at least composed of UHRF2, CDK2 and CCNE1.
    Function:
    E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of PCNP. May participate in methylation-dependent transcriptional regulation. Important for G1/S transition. Overexpression causes G1 phase cell arrest.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    803
    Sequence:
    50:
    MWIQVRTIDG | SQTRTIEDVS | RKATIEELRE | RVWALFDVRP | ECQRLFYRGK | 
    100:
    QLENGYTLFD | YDVGLNDIIQ | LLVRPDSSLP | STSKQNDAQV | KPSSHNPPKV | 
    150:
    KKTARGGSSS | QPSTSARTCL | IDPGFGLYKV | NELVDARDVG | LGAWFEAHIH | 
    200:
    SVTRASDGHS | RGKTPLKNGS | SYKRTNGNVN | HNSKENTNKL | DNVPSTSNSD | 
    250:
    SVAADEDVIY | HIEYDEYPES | GILEMNVKDL | RPRARTILKW | NELNVGDVVM | 
    300:
    VNYNVENPGK | RGFWYDAEIT | TLKTISRTKK | EVRVKVFLGG | SEGTLNDCRV | 
    350:
    MSVDEIFKIE | KPGAHPISFA | DGKFLRKNDP | ECDLCGGDPD | KTCHMCSCHK | 
    400:
    CGEKRDPNMQ | LLCDECNMAY | HIYCLSPPLD | KVPEEEYWYC | PSCKTDSSEV | 
    450:
    VKAGERLKLS | KKKAKMPSAS | TESRRDWGRG | MACVGRTKEC | TIVPSNHYGP | 
    500:
    IPGIPVGSTW | RFRVQVSEAG | VHRPHVGGIH | GRSNDGAYSL | VLAGGFEDEV | 
    550:
    DRGDEFTYTG | SGGKNLAGNK | RIGAPSADQT | LTNMNRALAL | NCDAPLDDKI | 
    600:
    GAESRNWRAG | KPVRVIRSFK | GRKISKYAPE | EGNRYDGIYK | VVKYWPEISS | 
    650:
    SHGFLVWRYL | LRRDDVEPAP | WTSEGIERSR | RLCLRLQYPA | GYPSEKEGKK | 
    700:
    TKGQSKKQGS | EATKRPASDD | ECPGDSKVLK | ASDSTDAVEA | FQLTPQQQRL | 
    750:
    IREDCQNQKL | WDEVLASLVE | GPNFLKKLEQ | SFMCVCCQEL | VYQPVTTECF | 
    800:
    HNVCKDCLQR | SFKAQVFSCP | ACRHDLGQNY | VMVLNETLQT | LLDLFFPGYS | 
    803:
    KGR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase UHRF2
    ELISA Kit for Mouse E3 ubiquitin-protein ligase UHRF2
    CLIA Kit for Mouse E3 ubiquitin-protein ligase UHRF2
    CLIA Kit for Mouse E3 ubiquitin-protein ligase UHRF2
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UHRF2
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase UHRF2
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase UHRF2
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase UHRF2
    Protein for Mouse E3 ubiquitin-protein ligase UHRF2
    Protein for Mouse E3 ubiquitin-protein ligase UHRF2

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "LMO2-induced T cell leukemias overexpress a novel gene, Uhr1, containing RING and PHD zinc fingers and an ubiquitin-like domain."
      Davenport J.W. , Fernandes E.R. , Neale G.A.M. , Goorha R.M.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Leukemic T-cell.
    2. 2.
      Mori T. , Li Y. , Kochi H.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: Swiss Webster / NIH.
      tissue: Embryo.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-195
      strain: C57BL/6J.
      tissue: Adipose tissue.
      tissue: Spinal ganglion.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Embryo.
    5. 5.
      "Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways."
      Pichler G. , Wolf P. , Schmidt C.S. , Meilinger D. , Schneider K. , Frauer C. , Fellinger K. , Rottach A. , Leonhardt H.
      J. Cell. Biochem.112:2585-2593(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH H3;SUBCELLULAR LOCATION;INDUCTION;MUTAGENESIS OF TYR-214 AND TYR-217
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