Protein unc-45 homolog A (Protein name
), UN45A_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
UNC45A(SMAP1);
Protein name:
Protein unc-45 homolog A(Unc-45A);
Alternative:
Smooth muscle cell-associated protein 1(SMAP-1);GCUNC-45;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PGR isoforms A and B as well as with NR3C1 in the absence of ligand, and with HSP90AB1. Binding to HSP90AB1 involves 2 UNC45A monomers per HSP90AB1 dimer.
Function:
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen.
Subcellular Location:
Cytoplasm
Cytoplasm
perinuclear region
Nucleus
Predominant in the perinuclear region. Little protein in the nucleus.
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Precision
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Recovery
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Linearity
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References
1.
"Molecular cloning and characterization of human smooth muscle cell associated protein-1 (SMAP-1)." Nishimoto S.
,
Toyoda H.
,
Tawara J.
,
Aoki T.
,
Komurasaki T.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 756-944
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for: FUNCTION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70 AND LYS-483;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
"The solution structure of the tetratricopeptide repeat of human smooth muscle cell associated protein-1." RIKEN structural genomics initiative (RSGI)
Submitted (2006-06) to the PDB data bank
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Cited for: STRUCTURE BY NMR OF 1-135
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PGR; NR3C1 AND HSP90AB1;MUTAGENESIS OF LYS-33; ALA-40; LYS-70 AND ALA-77