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Index > Protein center > Unc93b1(Gene name) > Mouse
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  • Unc93b1 (Gene name),
  • Protein unc-93 homolog B1 (Protein name ),  UN93B_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Unc93b1(Unc93b);
    Protein name:
    Protein unc-93 homolog B1(Unc-93B1);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TLR3, TLR7, TLR8, TLR9 and TLR13 (probably via transmembrane domain).
    Function:
    Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein Endosome Lysosome Cytoplasmic vesicle phagosome Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides.
    Protein Attributes:
    Sequence length:
    598
    Sequence:
    50:
    MEVEPPLYPV | AGAAGPQGDE | DRHGVPDGPE | APLDELVGAY | PNYNEEEEER | 
    100:
    RYYRRKRLGV | VKNVLAASTG | VTLTYGVYLG | LLQMQLILHY | DETYREVKYG | 
    150:
    NMGLPDIDSK | MLMGINVTPI | AALLYTPVLI | RFFGTKWMMF | LAVGIYALFV | 
    200:
    STNYWERYYT | LVPSAVALGM | AIVPLWASMG | NYITRMSQKY | YEYSHYKEQD | 
    250:
    EQGPQQRPPR | GSHAPYLLVF | QAIFYSFFHL | SFACAQLPMI | YFLNNYLYDL | 
    300:
    NHTLINVQSC | GTKSQGILNG | FNKTVLRTLP | RSKNLIVVES | VLMAVAFLAM | 
    350:
    LMVLGLCGAA | YRPTEEIDLR | SVGWGNIFQL | PFKHVRDFRL | RHLVPFFIYS | 
    400:
    GFEVLFACTG | FALGYGVCSM | GLERLAYLLI | AYSLGASASS | VLGLLGLWLP | 
    450:
    RSVPLVAGAG | LHLLLTLSLF | FWAPAPRVLQ | HSWIFYFVAA | LWGVGSALNK | 
    500:
    TGLSTLLGIL | YEDKERQDFI | FTIYHWWQAV | AIFVVYLGSS | LPMKAKLAVL | 
    550:
    LVTLVAAAAS | YLWMEQKLQQ | GLVPRQPRIP | KPQHKVRGYR | YLEEDNSDES | 
    598:
    DMEGEQGQGD | CAEDEAPQAG | PLGAEPAGPC | RKPCPYEQAL | GGDGPEEQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    UniGene:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Unc-93B1
    ELISA Kit for Mouse Unc-93B1
    CLIA Kit for Mouse Unc-93B1
    CLIA Kit for Mouse Unc-93B1
    Polyclonal Antibody for Mouse Unc-93B1
    Polyclonal Antibody for Mouse Unc-93B1
    Monoclonal Antibody for Mouse Unc-93B1
    Monoclonal Antibody for Mouse Unc-93B1
    Protein for Mouse Unc-93B1
    Protein for Mouse Unc-93B1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Oviduct.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: FVB/N.
      tissue: Colon.
      tissue: Mammary tumor.
    3. 3.
      "Cloning and characterization of mammalian homologs of unc-93 from Caenorhabditis elegans, a protein relevant for muscle contraction."
      Kollewe A.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 264-315 (ISOFORM 1)
      strain: C57BL/6 X CBA.
      tissue: Spleen.
    4. 4.
      "Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis."
      Chu C.C. , Paul W.E.
      Mol. Immunol.35:487-502(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 317-434 (ISOFORM 1);INDUCTION
      strain: BALB/c.
      tissue: Spleen.
    5. 5.
      "The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9."
      Tabeta K. , Hoebe K. , Janssen E.M. , Du X. , Georgel P. , Crozat K. , Mudd S. , Mann N. , Sovath S. , Goode J. , Shamel L. , Herskovits A.A. , Portnoy D.A. , Cooke M. , Tarantino L.M. , Wiltshire T. , Steinberg B.E. , Grinstein S. , more...
      Nat. Immunol.7:156-164(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF HIS-412;SUBCELLULAR LOCATION
    6. 6.
      "The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling."
      Brinkmann M.M. , Spooner E. , Hoebe K. , Beutler B. , Ploegh H.L. , Kim Y.M.
      J. Cell Biol.177:265-275(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION;INTERACTION WITH TLR3; TLR7; TLR9 AND TLR13
    7. 7.
      "UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes."
      Kim Y.M. , Brinkmann M.M. , Paquet M.E. , Ploegh H.L.
      Nature452:234-238(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing."
      Fukui R. , Saitoh S. , Matsumoto F. , Kozuka-Hata H. , Oyama M. , Tabeta K. , Beutler B. , Miyake K.
      J. Exp. Med.206:1339-1350(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-34;INTERACTION WITH TLR7; TLR8 AND TLR13
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