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Index > Protein center > Uncx(Gene name) > Mouse
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  • Uncx (Gene name),
  • Homeobox protein unc-4 homolog (Protein name ),  UNC4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Uncx(Uncx4.1);
    Protein name:
    Homeobox protein unc-4 homolog;
    Alternative:
    Homeobox protein Uncx4.1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    530
    Sequence:
    50:
    MMDGRLLEHP | HAQFGGSLGG | VVGFPYPLGH | HHVYELAGHQ | LQSAAAAAAA | 
    100:
    ASVPFSIDGL | LSGSCAAAAA | SVVNPTPLLP | AACGVAGESQ | PFKLADSGDP | 
    150:
    DKESPGCKRR | RTRTNFTGWQ | LEELEKAFNE | SHYPDVFMRE | ALALRLDLVE | 
    200:
    SRVQVWFQNR | RAKWRKKENT | KKGPGRPAHN | SHPTTCSGEP | MDPEEIARKE | 
    250:
    LEKMEKKKRK | HEKKLLKSQS | RHLHSPGGLS | LHSAPSSDSD | SGGGGLSPEP | 
    300:
    PEPPPPTAAA | KGPGAHGSGI | AGSAPVPPGE | PPAPGTCDPA | FYPSQRSGAG | 
    350:
    SQPRLGRPAD | KDTVPCGPGA | AATAGLPKAS | PFSVESLLSD | SPPRRKATPA | 
    400:
    NAAATAGLDF | TPGLPCAPRT | LIGKGHFLLY | PITQPLGFLV | PQAALKGGAG | 
    450:
    PELVPKDAPP | APPAPPAPPA | QASFGTFPGP | GGAADPAFAR | RSPEVVASPG | 
    500:
    PPAPASFRDL | TAAAAESGAG | DCADVGTVCP | AASPPPPLET | SPGPGPRAPS | 
    530:
    PPGEPATCGA | AEPGAATGPS | PPEGEEVDMD | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Homeobox protein unc-4 homolog
    ELISA Kit for Mouse Homeobox protein unc-4 homolog
    ELISA Kit for Mouse Homeobox protein unc-4 homolog
    CLIA Kit for Mouse Homeobox protein unc-4 homolog
    CLIA Kit for Mouse Homeobox protein unc-4 homolog
    CLIA Kit for Mouse Homeobox protein unc-4 homolog
    Polyclonal Antibody for Mouse Homeobox protein unc-4 homolog
    Polyclonal Antibody for Mouse Homeobox protein unc-4 homolog
    Polyclonal Antibody for Mouse Homeobox protein unc-4 homolog
    Monoclonal Antibody for Mouse Homeobox protein unc-4 homolog
    Monoclonal Antibody for Mouse Homeobox protein unc-4 homolog
    Monoclonal Antibody for Mouse Homeobox protein unc-4 homolog
    Protein for Mouse Homeobox protein unc-4 homolog
    Protein for Mouse Homeobox protein unc-4 homolog
    Protein for Mouse Homeobox protein unc-4 homolog

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column."
      Leitges M. , Neidhardt L. , Haenig B. , Herrmann B.G. , Kispert A.
      Development127:2259-2267(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;DISRUPTION PHENOTYPE
    2. 2.
      "Cloning and expression of the mouse homolog of Caenorhabditis elegans unc4 gene."
      Nicholson L.F.B. , Ma L. , Goulding M.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Spinal cord.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system."
      Mansouri A. , Yokota Y. , Wehr R. , Copeland N.G. , Jenkins N.A. , Gruss P.
      Dev. Dyn.210:53-65(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-387;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      strain: C57BL/6.
    5. 5.
      "Cloning and characterization of four murine homeobox genes."
      Rovescalli A.C. , Asoh S. , Nirenberg M.W.
      Proc. Natl. Acad. Sci. U.S.A.93:10691-10696(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 109-304
    6. 6.
      "Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse."
      del Barco Barrantes I. , Elia A.J. , Wuensch K. , De Angelis M.H. , Mak T.W. , Rossant J. , Conlon R.A. , Gossler A. , de la Pompa J.L.
      Curr. Biol.9:470-480(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    7. 7.
      "Adhesive subdivisions intrinsic to the epithelial somites."
      Horikawa K. , Radice G. , Takeichi M. , Chisaka O.
      Dev. Biol.215:182-189(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9."
      Mansouri A. , Voss A.K. , Thomas T. , Yokota Y. , Gruss P.
      Development127:2251-2258(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    9. 9.
      "Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites."
      Schubert F.R. , Tremblay P. , Mansouri A. , Faisst A.M. , Kammandel B. , Lumsden A. , Gruss P. , Dietrich S.
      Dev. Dyn.222:506-521(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis."
      Nomura-Kitabayashi A. , Takahashi Y. , Kitajima S. , Inoue T. , Takeda H. , Saga Y.
      Development129:2473-2481(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 11.
      "Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2."
      Nakajima Y. , Morimoto M. , Takahashi Y. , Koseki H. , Saga Y.
      Development133:2517-2525(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 12.
      "Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1."
      Asbreuk C.H.J. , van Doorninck J.H. , Mansouri A. , Smidt M.P. , Burbach J.P.H.
      J. Mol. Endocrinol.36:65-71(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
    13. 13.
      "Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation."
      Takahashi Y. , Takagi A. , Hiraoka S. , Koseki H. , Kanno J. , Rawls A. , Saga Y.
      Dev. Dyn.236:1484-1494(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    14. 14.
      "Ripply2 is essential for precise somite formation during mouse early development."
      Chan T. , Kondow A. , Hosoya A. , Hitachi K. , Yukita A. , Okabayashi K. , Nakamura H. , Ozawa H. , Kiyonari H. , Michiue T. , Ito Y. , Asashima M.
      FEBS Lett.581:2691-2696(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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