Unc5a ELISA Kit for Rat(Rattus norvegicus) | EIAab.comUnc5a ELISA Kit for Rat(Rattus norvegicus)

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Unc5a (Gene name),

Netrin receptor UNC5A (Protein name ), UNC5A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Unc5a(Unc5h1);

Protein name:

Netrin receptor UNC5A;

Alternative:

Protein unc-5 homolog A;Protein unc-5 homolog 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC.

Function:

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Subcellular Location:

Cell membrane Single-pass type I membrane protein The interaction with PRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones.

Protein Attributes:

Sequence length:

898

Sequence:

50:

100:

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250:

300:

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650:

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850:

898:

SKPSPTAMIL | NLWEARHFPN | GNLGQLAAAV | AGLGQPDAGL | FTVSEAEC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O08721

SMR:

O08721

KEGG:

rno:60629

Pfam:

PF00531

STRING:

10116.ENSRNOP00000032250

UniGene:

Rn.44433

Uniprot:

O08721

FOR

ELISA Kit for Rat Netrin receptor UNC5A

CLIA Kit for Rat Netrin receptor UNC5A

Polyclonal Antibody for Rat Netrin receptor UNC5A

Monoclonal Antibody for Rat Netrin receptor UNC5A

Protein for Rat Netrin receptor UNC5A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors."
Leonardo E.D. , Hinck L. , Masu M. , Keino-Masu K. , Ackerman S.L. , Tessier-Lavigne M.
Nature386:833-838(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Ventral spinal cord.
2.

"A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion."
Hong K. , Hinck L. , Nishiyama M. , Poo M.-M. , Tessier-Lavigne M. , Stein E.
Cell97:927-941(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DCC
3.

"Expression patterns of the netrin receptor UNC5H1 among developing motor neurons in the embryonic rat hindbrain."
Barrett C. , Guthrie S.
Mech. Dev.106:163-166(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
4.

"Netrin-1 acts as a survival factor via its receptors UNC5H and DCC."
Llambi F. , Causeret F. , Bloch-Gallego E. , Mehlen P.
EMBO J.20:2715-2722(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE."
Williams M.E. , Strickland P. , Watanabe K. , Hinck L.
J. Biol. Chem.278:17483-17490(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MAGED1
6.

"Surface expression of the netrin receptor UNC5H1 is regulated through a protein kinase C-interacting protein/protein kinase-dependent mechanism."
Williams M.E. , Wu S.C.-Y. , McKenna W.L. , Hinck L.
J. Neurosci.23:11279-11288(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRKCABP;PHOSPHORYLATION;MUTAGENESIS OF 896-ALA--CYS-898

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