Protein name:
Urokinase-type plasminogen activator (U-plasminogen activator;uPA) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.
Function:
Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.
Subcellular Location:
Secreted
Protein Attributes:
50:
MRALLARLLL | CVLVVSDSKG | SNELHQVPSN | CDCLNGGTCV | SNKYFSNIHW |
100:
CNCPKKFGGQ | HCEIDKSKTC | YEGNGHFYRG | KASTDTMGRP | CLPWNSATVL |
150:
QQTYHAHRSD | ALQLGLGKHN | YCRNPDNRRR | PWCYVQVGLK | PLVQECMVHD |
200:
CADGKKPSSP | PEELKFQCGQ | KTLRPRFKII | GGEFTTIENQ | PWFAAIYRRH |
250:
RGGSVTYVCG | GSLISPCWVI | SATHCFIDYP | KKEDYIVYLG | RSRLNSNTQG |
300:
EMKFEVENLI | LHKDYSADTL | AHHNDIALLK | IRSKEGRCAQ | PSRTIQTICL |
350:
PSMYNDPQFG | TSCEITGFGK | ENSTDYLYPE | QLKMTVVKLI | SHRECQQPHY |
400:
YGSEVTTKML | CAADPQWKTD | SCQGDSGGPL | VCSLQGRMTL | TGIVSWGRGC |
431:
ALKDKPGVYT | RVSHFLPWIR | SHTKEENGLA | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Chicken
Pig
Rat
Rabbit
ELISA Kit for Human U-plasminogen activator
ELISA Kit for Human U-plasminogen activator
ELISA Kit for Human U-plasminogen activator
ELISA Kit for Human U-plasminogen activator
ELISA Kit for Human U-plasminogen activator
ELISA Kit for Human U-plasminogen activator
ELISA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
CLIA Kit for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Polyclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Monoclonal Antibody for Human U-plasminogen activator
Protein for Human U-plasminogen activator
Protein for Human U-plasminogen activator
Protein for Human U-plasminogen activator
Protein for Human U-plasminogen activator
Protein for Human U-plasminogen activator
Protein for Human U-plasminogen activator
Protein for Human U-plasminogen activator
R&D Technical Data
12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Mesangial cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-15; LEU-141 AND GLN-231
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Nature429:375-381(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-141
9.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
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Halpern A.L.
,
Mobarry C.M.
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Lippert R.
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Walenz B.
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Shatkay H.
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Dew I.
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Miller J.R.
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Zheng X.H.
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Myers E.W.
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Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lung .
11.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 21-431;VARIANT LEU-141
12.
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Cited for : PROTEIN SEQUENCE OF 21-43;GLYCOSYLATION AT THR-38;IDENTIFICATION BY MASS SPECTROMETRY
13.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 66-431;VARIANT MET-214
14.
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Cited for : PROTEIN SEQUENCE OF 21-177
15.
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Cited for : PROTEIN SEQUENCE OF 156-176 AND 179-224
16.
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Cited for : PROTEIN SEQUENCE OF 158-410
17.
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Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
18.
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Cited for : PHOSPHORYLATION AT SER-158 AND SER-323;MUTAGENESIS OF SER-158 AND SER-323
19.
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Cited for : HETERODIMER WITH SERPINA5
20.
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Cited for : INTERACTION WITH MRC2
21.
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Cited for : INTERACTION WITH LRP1B
22.
"Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma."
Wakita T.
,
Hayashi T.
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Nishioka J.
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Tamaru H.
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Akita N.
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Asanuma K.
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Kamada H.
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Gabazza E.C.
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Ido M.
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Kawamura J.
,
Suzuki K.
Int. J. Cancer108:516-523(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : ENZYME REGULATION;HETERODIMER WITH SERPINA5
23.
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Cited for : TISSUE SPECIFICITY
24.
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Cited for : INVOLVEMENT IN QPD
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR
26.
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Cited for : STRUCTURE BY NMR OF 67-155
27.
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Cited for : STRUCTURE BY NMR OF 67-155
28.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
29.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 159-411
30.
"Structure of human urokinase plasminogen activator in complex with its receptor."
Huai Q.
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Mazar A.P.
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Kuo A.
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Parry G.C.
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Shaw D.E.
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Callahan J.
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Li Y.
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Chen L.
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Furie B.
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Furie B.C.
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Cines D.B.
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Huang M.
Science311:656-659(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 31-152 IN COMPLEX WITH PLAUR
31.
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Cited for : VARIANT LEU-141
32.
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Cited for : ERRATUM
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LEU-141
34.
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J.
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Mardis E.R.
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Ding L.
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Fulton B.
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McLellan M.D.
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Chen K.
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Dunford-Shore B.H.
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Graubert T.A.
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DiPersio J.F.
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Wilson R.K.
more...
Nature456:66-72(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] LEU-141