Protein name:
UV-stimulated scaffold protein A ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with the elongating form of RNA polymerase II (RNA pol IIo). Interacts with ERCC6, ERCC8 and USP7.
Function:
Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
Subcellular Location:
Chromosome
Accumulates at UV DNA damage sites.
Protein Attributes:
50:
MDQKLSQLIE | ELTTSGESQL | NAQKMKELKK | ICKSSEEQLS | HAYRLLMTQL |
100:
TQDHAEIRLS | AFQIVDELFT | RSHQFRVLLV | SDFQEFLELT | LGTDNDHPLP |
150:
PPREAAQRLR | QAAMQAVEGW | NEKFGEAYKK | LALGYHFLKH | TKKVDFRDIN |
200:
VRTLAERKRE | EEKQKHLDKI | HRESADRAKR | EMEEMSDEIG | CCLTEVENCF |
250:
RLLVPLDLGP | YREDKFFGEA | SGIAEDHAPC | AWSPDLATPR | GSGLSGPQDE |
300:
EQPCCSKDLV | ASAHHAGSAV | GLKAPAPAAT | EDPCRDEDRH | SEHSDPEDFL |
350:
RSHGLGSHKY | TLDVELPSDG | LKVQENEDNL | AVLHAARDSL | KLIQNKFLPA |
400:
VCSWVQRFTR | AGIYSGHLKQ | AIDLKMELEL | ALKKYEELNI | EPGRGQRSRT |
450:
EALEDSEEED | QDFVEVPEKE | GYEPRIPDHL | RAEYGLEPKA | PLKTLEKHTA |
500:
VCSVQERTRR | RREEEASDPT | SAAAQMLRLQ | DCLSSPSSSS | TRGPLGPEEA |
550:
QKQAERARAP | MVPFGVDLCY | WGQEQLTAGK | ILKSDSQHRF | WKPHEVEEEV |
600:
DSAHVSEMLH | SRHITFSGKF | EPVQHKCRAL | RPNGRLCERQ | DRLKCPFHGK |
650:
IIPRDDKGQP | LNPEDRAREQ | RQQLQQQRAH | PDWQDPEFMK | DVEAATGVDL |
700:
GSSKYSKKGK | GKKKKHPNLT | DLRERANTAR | ARLEKKVFAK | GAVQRVVAAM |
720:
NQMDQKKHEK | FANQFNYALK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Rat
Chicken
Mouse
ELISA Kit for Rat UV-stimulated scaffold protein A
ELISA Kit for Rat UV-stimulated scaffold protein A
ELISA Kit for Rat UV-stimulated scaffold protein A
ELISA Kit for Rat UV-stimulated scaffold protein A
ELISA Kit for Rat UV-stimulated scaffold protein A
CLIA Kit for Rat UV-stimulated scaffold protein A
CLIA Kit for Rat UV-stimulated scaffold protein A
CLIA Kit for Rat UV-stimulated scaffold protein A
CLIA Kit for Rat UV-stimulated scaffold protein A
CLIA Kit for Rat UV-stimulated scaffold protein A
Polyclonal Antibody for Rat UV-stimulated scaffold protein A
Polyclonal Antibody for Rat UV-stimulated scaffold protein A
Polyclonal Antibody for Rat UV-stimulated scaffold protein A
Polyclonal Antibody for Rat UV-stimulated scaffold protein A
Polyclonal Antibody for Rat UV-stimulated scaffold protein A
Monoclonal Antibody for Rat UV-stimulated scaffold protein A
Monoclonal Antibody for Rat UV-stimulated scaffold protein A
Monoclonal Antibody for Rat UV-stimulated scaffold protein A
Monoclonal Antibody for Rat UV-stimulated scaffold protein A
Monoclonal Antibody for Rat UV-stimulated scaffold protein A
Protein for Rat UV-stimulated scaffold protein A
Protein for Rat UV-stimulated scaffold protein A
Protein for Rat UV-stimulated scaffold protein A
Protein for Rat UV-stimulated scaffold protein A
Protein for Rat UV-stimulated scaffold protein A
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 596-720
strain :
Sprague-Dawley .