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Index > Protein center > Uvssa(Gene name) > Rat
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  • Uvssa (Gene name),
  • UV-stimulated scaffold protein A (Protein name ),  UVSSA_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Uvssa;
    Protein name:
    UV-stimulated scaffold protein A;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with the elongating form of RNA polymerase II (RNA pol IIo). Interacts with ERCC6, ERCC8 and USP7.
    Function:
    Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
    Subcellular Location:
    Chromosome Accumulates at UV DNA damage sites.
    Protein Attributes:
    Sequence length:
    720
    Sequence:
    50:
    MDQKLSQLIE | ELTTSGESQL | NAQKMKELKK | ICKSSEEQLS | HAYRLLMTQL | 
    100:
    TQDHAEIRLS | AFQIVDELFT | RSHQFRVLLV | SDFQEFLELT | LGTDNDHPLP | 
    150:
    PPREAAQRLR | QAAMQAVEGW | NEKFGEAYKK | LALGYHFLKH | TKKVDFRDIN | 
    200:
    VRTLAERKRE | EEKQKHLDKI | HRESADRAKR | EMEEMSDEIG | CCLTEVENCF | 
    250:
    RLLVPLDLGP | YREDKFFGEA | SGIAEDHAPC | AWSPDLATPR | GSGLSGPQDE | 
    300:
    EQPCCSKDLV | ASAHHAGSAV | GLKAPAPAAT | EDPCRDEDRH | SEHSDPEDFL | 
    350:
    RSHGLGSHKY | TLDVELPSDG | LKVQENEDNL | AVLHAARDSL | KLIQNKFLPA | 
    400:
    VCSWVQRFTR | AGIYSGHLKQ | AIDLKMELEL | ALKKYEELNI | EPGRGQRSRT | 
    450:
    EALEDSEEED | QDFVEVPEKE | GYEPRIPDHL | RAEYGLEPKA | PLKTLEKHTA | 
    500:
    VCSVQERTRR | RREEEASDPT | SAAAQMLRLQ | DCLSSPSSSS | TRGPLGPEEA | 
    550:
    QKQAERARAP | MVPFGVDLCY | WGQEQLTAGK | ILKSDSQHRF | WKPHEVEEEV | 
    600:
    DSAHVSEMLH | SRHITFSGKF | EPVQHKCRAL | RPNGRLCERQ | DRLKCPFHGK | 
    650:
    IIPRDDKGQP | LNPEDRAREQ | RQQLQQQRAH | PDWQDPEFMK | DVEAATGVDL | 
    700:
    GSSKYSKKGK | GKKKKHPNLT | DLRERANTAR | ARLEKKVFAK | GAVQRVVAAM | 
    720:
    NQMDQKKHEK | FANQFNYALK | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat UV-stimulated scaffold protein A
    ELISA Kit for Rat UV-stimulated scaffold protein A
    ELISA Kit for Rat UV-stimulated scaffold protein A
    ELISA Kit for Rat UV-stimulated scaffold protein A
    ELISA Kit for Rat UV-stimulated scaffold protein A
    CLIA Kit for Rat UV-stimulated scaffold protein A
    CLIA Kit for Rat UV-stimulated scaffold protein A
    CLIA Kit for Rat UV-stimulated scaffold protein A
    CLIA Kit for Rat UV-stimulated scaffold protein A
    CLIA Kit for Rat UV-stimulated scaffold protein A
    Polyclonal Antibody for Rat UV-stimulated scaffold protein A
    Polyclonal Antibody for Rat UV-stimulated scaffold protein A
    Polyclonal Antibody for Rat UV-stimulated scaffold protein A
    Polyclonal Antibody for Rat UV-stimulated scaffold protein A
    Polyclonal Antibody for Rat UV-stimulated scaffold protein A
    Monoclonal Antibody for Rat UV-stimulated scaffold protein A
    Monoclonal Antibody for Rat UV-stimulated scaffold protein A
    Monoclonal Antibody for Rat UV-stimulated scaffold protein A
    Monoclonal Antibody for Rat UV-stimulated scaffold protein A
    Monoclonal Antibody for Rat UV-stimulated scaffold protein A
    Protein for Rat UV-stimulated scaffold protein A
    Protein for Rat UV-stimulated scaffold protein A
    Protein for Rat UV-stimulated scaffold protein A
    Protein for Rat UV-stimulated scaffold protein A
    Protein for Rat UV-stimulated scaffold protein A

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    3. 3.
      "Normalization and subtraction: two approaches to facilitate gene discovery."
      Bonaldo M.F. , Lennon G. , Soares M.B.
      Genome Res.6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 596-720
      strain: Sprague-Dawley.
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