Gene name:
VAC14 (TAX1BP2;TRX) ;
Protein name:
Protein VAC14 homolog ;
Alternative:
Tax1-binding protein 2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Interacts with NOS1. Interacts with HTLV-1 Tax.
Function:
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Subcellular Location:
Endosome membrane
Microsome membrane
Mainly associated with membranes of the late endocytic pathway.
Protein Attributes:
50:
MNPEKDFAPL | TPNIVRALND | KLYEKRKVAA | LEIEKLVREF | VAQNNTVQIK |
100:
HVIQTLSQEF | ALSQHPHSRK | GGLIGLAACS | IALGKDSGLY | LKELIEPVLT |
150:
CFNDADSRLR | YYACEALYNI | VKVARGAVLP | HFNVLFDGLS | KLAADPDPNV |
200:
KSGSELLDRL | LKDIVTESNK | FDLVSFIPLL | RERIYSNNQY | ARQFIISWIL |
250:
VLESVPDINL | LDYLPEILDG | LFQILGDNGK | EIRKMCEVVL | GEFLKEIKKN |
300:
PSSVKFAEMA | NILVIHCQTT | DDLIQLTAMC | WMREFIQLAG | RVMLPYSSGI |
350:
LTAVLPCLAY | DDRKKSIKEV | ANVCNQSLMK | LVTPEDDELD | ELRPGQRQAE |
400:
PTPDDALPKQ | EGTASGGPDG | SCDSSFSSGI | SVFTAASTER | APVTLHLDGI |
450:
VQVLNCHLSD | TAIGMMTRIA | VLKWLYHLYI | KTPRKMFRHT | DSLFPILLQT |
500:
LSDESDEVIL | KDLEVLAEIA | SSPAGQTDDP | GPLDGPDLQA | SHSELQVPTP |
550:
GRAGLLNTSG | TKGLECSPST | PTMNSYFYKF | MINLLKRFSS | ERKLLEVRGP |
600:
FIIRQLCLLL | NAENIFHSMA | DILLREEDLK | FASTMVHALN | TILLTSTELF |
650:
QLRNQLKDLK | TLESQNLFCC | LYRSWCHNPV | TTVSLCFLTQ | NYRHAYDLIQ |
700:
KFGDLEVTVD | FLAEVDKLVQ | LIECPIFTYL | RLQLLDVKNN | PYLIKALYGL |
750:
LMLLPQSSAF | QLLSHRLQCV | PNPELLQTED | SLKAAPKSQK | ADSPSIDYAE |
782:
LLQHFEKVQN | KHLEVRHQRS | GRGDHLDRRV | VL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Rat
Chicken
Human
ELISA Kit for Human Protein VAC14 homolog
ELISA Kit for Human Protein VAC14 homolog
ELISA Kit for Human Protein VAC14 homolog
ELISA Kit for Human Protein VAC14 homolog
ELISA Kit for Human Protein VAC14 homolog
CLIA Kit for Human Protein VAC14 homolog
CLIA Kit for Human Protein VAC14 homolog
CLIA Kit for Human Protein VAC14 homolog
CLIA Kit for Human Protein VAC14 homolog
CLIA Kit for Human Protein VAC14 homolog
Polyclonal Antibody for Human Protein VAC14 homolog
Polyclonal Antibody for Human Protein VAC14 homolog
Polyclonal Antibody for Human Protein VAC14 homolog
Polyclonal Antibody for Human Protein VAC14 homolog
Polyclonal Antibody for Human Protein VAC14 homolog
Monoclonal Antibody for Human Protein VAC14 homolog
Monoclonal Antibody for Human Protein VAC14 homolog
Monoclonal Antibody for Human Protein VAC14 homolog
Monoclonal Antibody for Human Protein VAC14 homolog
Monoclonal Antibody for Human Protein VAC14 homolog
Protein for Human Protein VAC14 homolog
Protein for Human Protein VAC14 homolog
Protein for Human Protein VAC14 homolog
Protein for Human Protein VAC14 homolog
Protein for Human Protein VAC14 homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Trachea .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Lung .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 244-366 (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH HTLV-I TAX
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-782 (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NOS1;MUTAGENESIS OF GLY-773; ASP-774; LEU-776; ASP-777; 780-VAL--LEU-782 AND LEU-782
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT;IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX;DOMAIN
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]