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Index > Protein center > VAC14(Gene name) > Human
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  • VAC14 (Gene name),
  • Protein VAC14 homolog (Protein name ),  VAC14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VAC14(TAX1BP2;TRX);
    Protein name:
    Protein VAC14 homolog;
    Alternative:
    Tax1-binding protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms homooligomers. Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold. Interacts with NOS1. Interacts with HTLV-1 Tax.
    Function:
    The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
    Subcellular Location:
    Endosome membrane Microsome membrane Mainly associated with membranes of the late endocytic pathway.
    Protein Attributes:
    Sequence length:
    782
    Sequence:
    50:
    MNPEKDFAPL | TPNIVRALND | KLYEKRKVAA | LEIEKLVREF | VAQNNTVQIK | 
    100:
    HVIQTLSQEF | ALSQHPHSRK | GGLIGLAACS | IALGKDSGLY | LKELIEPVLT | 
    150:
    CFNDADSRLR | YYACEALYNI | VKVARGAVLP | HFNVLFDGLS | KLAADPDPNV | 
    200:
    KSGSELLDRL | LKDIVTESNK | FDLVSFIPLL | RERIYSNNQY | ARQFIISWIL | 
    250:
    VLESVPDINL | LDYLPEILDG | LFQILGDNGK | EIRKMCEVVL | GEFLKEIKKN | 
    300:
    PSSVKFAEMA | NILVIHCQTT | DDLIQLTAMC | WMREFIQLAG | RVMLPYSSGI | 
    350:
    LTAVLPCLAY | DDRKKSIKEV | ANVCNQSLMK | LVTPEDDELD | ELRPGQRQAE | 
    400:
    PTPDDALPKQ | EGTASGGPDG | SCDSSFSSGI | SVFTAASTER | APVTLHLDGI | 
    450:
    VQVLNCHLSD | TAIGMMTRIA | VLKWLYHLYI | KTPRKMFRHT | DSLFPILLQT | 
    500:
    LSDESDEVIL | KDLEVLAEIA | SSPAGQTDDP | GPLDGPDLQA | SHSELQVPTP | 
    550:
    GRAGLLNTSG | TKGLECSPST | PTMNSYFYKF | MINLLKRFSS | ERKLLEVRGP | 
    600:
    FIIRQLCLLL | NAENIFHSMA | DILLREEDLK | FASTMVHALN | TILLTSTELF | 
    650:
    QLRNQLKDLK | TLESQNLFCC | LYRSWCHNPV | TTVSLCFLTQ | NYRHAYDLIQ | 
    700:
    KFGDLEVTVD | FLAEVDKLVQ | LIECPIFTYL | RLQLLDVKNN | PYLIKALYGL | 
    750:
    LMLLPQSSAF | QLLSHRLQCV | PNPELLQTED | SLKAAPKSQK | ADSPSIDYAE | 
    782:
    LLQHFEKVQN | KHLEVRHQRS | GRGDHLDRRV | VL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    MIM:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein VAC14 homolog
    ELISA Kit for Human Protein VAC14 homolog
    ELISA Kit for Human Protein VAC14 homolog
    ELISA Kit for Human Protein VAC14 homolog
    ELISA Kit for Human Protein VAC14 homolog
    CLIA Kit for Human Protein VAC14 homolog
    CLIA Kit for Human Protein VAC14 homolog
    CLIA Kit for Human Protein VAC14 homolog
    CLIA Kit for Human Protein VAC14 homolog
    CLIA Kit for Human Protein VAC14 homolog
    Polyclonal Antibody for Human Protein VAC14 homolog
    Polyclonal Antibody for Human Protein VAC14 homolog
    Polyclonal Antibody for Human Protein VAC14 homolog
    Polyclonal Antibody for Human Protein VAC14 homolog
    Polyclonal Antibody for Human Protein VAC14 homolog
    Monoclonal Antibody for Human Protein VAC14 homolog
    Monoclonal Antibody for Human Protein VAC14 homolog
    Monoclonal Antibody for Human Protein VAC14 homolog
    Monoclonal Antibody for Human Protein VAC14 homolog
    Monoclonal Antibody for Human Protein VAC14 homolog
    Protein for Human Protein VAC14 homolog
    Protein for Human Protein VAC14 homolog
    Protein for Human Protein VAC14 homolog
    Protein for Human Protein VAC14 homolog
    Protein for Human Protein VAC14 homolog

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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Trachea.
    2. 2.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Lung.
    4. 4.
      "Isolation of a cDNA clone, TRX encoding a human T-cell lymphotrophic virus type-I Tax1 binding protein."
      Mireskandari A. , Reid R.L. , Kashanchi F. , Dittmer J. , Li W.B. , Brady J.N.
      Biochim. Biophys. Acta1306:9-13(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 244-366 (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH HTLV-I TAX
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-782 (ISOFORM 1)
    6. 6.
      "A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity."
      Sbrissa D. , Ikonomov O.C. , Strakova J. , Dondapati R. , Mlak K. , Deeb R. , Silver R. , Shisheva A.
      Mol. Cell. Biol.24:10437-10447(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "Binding of Vac14 to neuronal nitric oxide synthase: Characterisation of a new internal PDZ-recognition motif."
      Lemaire J.F. , McPherson P.S.
      FEBS Lett.580:6948-6954(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOS1;MUTAGENESIS OF GLY-773; ASP-774; LEU-776; ASP-777; 780-VAL--LEU-782 AND LEU-782
    8. 8.
      "Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex."
      Sbrissa D. , Ikonomov O.C. , Fu Z. , Ijuin T. , Gruenberg J. , Takenawa T. , Shisheva A.
      J. Biol. Chem.282:23878-23891(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX
    9. 9.
      "ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality."
      Sbrissa D. , Ikonomov O.C. , Fenner H. , Shisheva A.
      J. Mol. Biol.384:766-779(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;IDENTIFICATION IN THE PI(3,5)P2 REGULATORY COMPLEX;DOMAIN
    10. 10.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-11 AND THR-499;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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