Protein name:
Vesicle-associated membrane protein 7 (VAMP-7) ;
Alternative:
Tetanus-insensitive VAMP (Ti-VAMP) ;Synaptobrevin-like protein 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells.
Function:
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
Subcellular Location:
Cytoplasmic vesicle
secretory vesicle membrane
Single-pass type IV membrane protein
Golgi apparatus
trans-Golgi network membrane
Single-pass type IV membrane protein
Late endosome membrane
Single-pass type IV membrane protein
Lysosome membrane
Single-pass type IV membrane protein
Endoplasmic reticulum membrane
Single-pass type IV membrane protein
Cytoplasmic vesicle
phagosome membrane
Single-pass type IV membrane protein
Protein Attributes:
50:
MAILFAVVAR | GTTILAKHAW | CGGNFLEVTE | QILAKIPSEN | NKLTYSHGNY |
100:
LFHYICQDRI | VYLCITDDDF | ERSRAFNFLN | EIKKRFQTTY | GSRAQTALPY |
150:
AMNSEFSSVL | AAQLKHHSEN | KGLDKVMETQ | AQVDELKGIM | VRNIDLVAQR |
200:
GERLELLIDK | TENLVDSSVT | FKTTSRNLAR | AMCMKNLKLT | IIIIIVSIVF |
220:
IYIIVSPLCG | GFTWPSCVKK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Chicken
Human
Mouse
Rat
Bovine
ELISA Kit for Human VAMP-7
ELISA Kit for Human VAMP-7
ELISA Kit for Human VAMP-7
ELISA Kit for Human VAMP-7
ELISA Kit for Human VAMP-7
CLIA Kit for Human VAMP-7
CLIA Kit for Human VAMP-7
CLIA Kit for Human VAMP-7
CLIA Kit for Human VAMP-7
CLIA Kit for Human VAMP-7
Polyclonal Antibody for Human VAMP-7
Polyclonal Antibody for Human VAMP-7
Polyclonal Antibody for Human VAMP-7
Polyclonal Antibody for Human VAMP-7
Polyclonal Antibody for Human VAMP-7
Monoclonal Antibody for Human VAMP-7
Monoclonal Antibody for Human VAMP-7
Monoclonal Antibody for Human VAMP-7
Monoclonal Antibody for Human VAMP-7
Monoclonal Antibody for Human VAMP-7
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Hippocampus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-10; 126-137 AND 143-150;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Biochem. Biophys. Res. Commun.366:617-623(2008)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 1-118