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Index > Protein center > VAMP7(Gene name) > Human
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  • VAMP7 (Gene name),
  • Vesicle-associated membrane protein 7 (Protein name ),  VAMP7_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VAMP7(SYBL1);
    Protein name:
    Vesicle-associated membrane protein 7(VAMP-7);
    Alternative:
    Tetanus-insensitive VAMP(Ti-VAMP);Synaptobrevin-like protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells.
    Function:
    Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
    Subcellular Location:
    Cytoplasmic vesicle secretory vesicle membrane Single-pass type IV membrane protein Golgi apparatus trans-Golgi network membrane Single-pass type IV membrane protein Late endosome membrane Single-pass type IV membrane protein Lysosome membrane Single-pass type IV membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Cytoplasmic vesicle phagosome membrane Single-pass type IV membrane protein
    Protein Attributes:
    Sequence length:
    220
    Sequence:
    50:
    MAILFAVVAR | GTTILAKHAW | CGGNFLEVTE | QILAKIPSEN | NKLTYSHGNY | 
    100:
    LFHYICQDRI | VYLCITDDDF | ERSRAFNFLN | EIKKRFQTTY | GSRAQTALPY | 
    150:
    AMNSEFSSVL | AAQLKHHSEN | KGLDKVMETQ | AQVDELKGIM | VRNIDLVAQR | 
    200:
    GERLELLIDK | TENLVDSSVT | FKTTSRNLAR | AMCMKNLKLT | IIIIIVSIVF | 
    220:
    IYIIVSPLCG | GFTWPSCVKK | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human VAMP-7
    ELISA Kit for Human VAMP-7
    ELISA Kit for Human VAMP-7
    ELISA Kit for Human VAMP-7
    ELISA Kit for Human VAMP-7
    CLIA Kit for Human VAMP-7
    CLIA Kit for Human VAMP-7
    CLIA Kit for Human VAMP-7
    CLIA Kit for Human VAMP-7
    CLIA Kit for Human VAMP-7
    Polyclonal Antibody for Human VAMP-7
    Polyclonal Antibody for Human VAMP-7
    Polyclonal Antibody for Human VAMP-7
    Polyclonal Antibody for Human VAMP-7
    Polyclonal Antibody for Human VAMP-7
    Monoclonal Antibody for Human VAMP-7
    Monoclonal Antibody for Human VAMP-7
    Monoclonal Antibody for Human VAMP-7
    Monoclonal Antibody for Human VAMP-7
    Monoclonal Antibody for Human VAMP-7
    Protein for Human VAMP-7
    Protein for Human VAMP-7
    Protein for Human VAMP-7
    Protein for Human VAMP-7
    Protein for Human VAMP-7

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation."
      D'Esposito M. , Ciccodicola A. , Gianfrancesco F. , Esposito T. , Flagiello L. , Mazzarella R. , Schlessinger D. , D'Urso M.
      Nat. Genet.13:227-229(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Brain.
    4. 4.
      "Alternative splicing of SYBL1 gene."
      D'Esposito M. , Filippini F. , Rossi V. , D'Urso M.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Liver.
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hippocampus.
      tissue: Uterus.
    8. 8.
      Bienvenut W.V.
      Submitted (2005-06) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-10; 126-137 AND 143-150;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
    9. 9.
      "Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages."
      Ward D.M. , Pevsner J. , Scullion M.A. , Vaughn M. , Kaplan J.
      Mol. Biol. Cell11:2327-2333(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils."
      Logan M.R. , Lacy P. , Odemuyiwa S.O. , Steward M. , Davoine F. , Kita H. , Moqbel R.
      Allergy61:777-784(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Placenta.
    12. 12.
      "Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line."
      Marcet-Palacios M. , Odemuyiwa S.O. , Coughlin J.J. , Garofoli D. , Ewen C. , Davidson C.E. , Ghaffari M. , Kane K.P. , Lacy P. , Logan M.R. , Befus A.D. , Bleackley R.C. , Moqbel R.
      Biochem. Biophys. Res. Commun.366:617-623(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Solution structure of the longin domain of synaptobrevin-like protein 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-10) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-118
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