Vamp7 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comVamp7 ELISA Kit for Rat(Rattus norvegicus)

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Vamp7 (Gene name),

Vesicle-associated membrane protein 7 (Protein name ), VAMP7_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Vamp7(Sybl1);

Protein name:

Vesicle-associated membrane protein 7(VAMP-7);

Alternative:

Synaptobrevin-like protein 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells.

Function:

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

Subcellular Location:

Cytoplasmic vesicle secretory vesicle membrane Single-pass type IV membrane protein Golgi apparatus trans-Golgi network membrane Single-pass type IV membrane protein Late endosome membrane Single-pass type IV membrane protein Lysosome membrane Single-pass type IV membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Cytoplasmic vesicle phagosome membrane Single-pass type IV membrane protein In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with Lamp1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney.

Protein Attributes:

Sequence length:

220

Sequence:

50:

100:

150:

200:

220:

IYIIVSPLCG | GFTWPSCVKK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00957

STRING:

10116.ENSRNOP00000011065

Pfam:

PF13774

UniGene:

Rn.34151

String:

Q9JHW5

KEGG:

rno:85491

SMR:

Q9JHW5

Uniprot:

Q9JHW5

FOR

ELISA Kit for Rat VAMP-7

CLIA Kit for Rat VAMP-7

Polyclonal Antibody for Rat VAMP-7

Monoclonal Antibody for Rat VAMP-7

Protein for Rat VAMP-7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Rat basophilic leukemia cells express syntaxin-3 and VAMP-7 in granule membranes."
Hibi T. , Hirashima N. , Nakanishi M.
Biochem. Biophys. Res. Commun.271:36-41(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Seven novel mammalian SNARE proteins localize to distinct membrane compartments."
Advani R.J. , Bae H.-R. , Bock J.B. , Chao D.S. , Doung Y.-C. , Prekeris R. , Yoo J.-S. , Scheller R.H.
J. Biol. Chem.273:10317-10324(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
3.

"VAMP-7 mediates vesicular transport from endosomes to lysosomes."
Advani R.J. , Yang B. , Prekeris R. , Lee K.C. , Klumperman J. , Scheller R.H.
J. Cell Biol.146:765-776(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
4.

"Subcellular localization of tetanus neurotoxin-insensitive vesicle-associated membrane protein (VAMP)/VAMP7 in neuronal cells: evidence for a novel membrane compartment."
Coco S. , Raposo G. , Martinez S. , Fontaine J.-J. , Takamori S. , Zahraoui A. , Jahn R. , Matteoli M. , Louvard D. , Galli T.
J. Neurosci.19:9803-9812(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.

"Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events."
Pryor P.R. , Mullock B.M. , Bright N.A. , Lindsay M.R. , Gray S.R. , Richardson S.C.W. , Stewart A. , James D.E. , Piper R.C. , Luzio J.P.
EMBO Rep.5:590-595(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SNARE COMPLEX CHARACTERIZATION
6.

"Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis."
Rao S.K. , Huynh C. , Proux-Gillardeaux V. , Galli T. , Andrews N.W.
J. Biol. Chem.279:20471-20479(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SNARE COMPLEX CHARACTERIZATION
7.

"Vesicle-associated membrane protein 7 is expressed in intestinal ER."
Siddiqi S.A. , Mahan J. , Siddiqi S. , Gorelick F.S. , Mansbach C.M. II
J. Cell Sci.119:943-950(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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