VAV1 ELISA Kit for Human(Homo sapiens) | EIAab.comVAV1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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VAV1 (Gene name),

Proto-oncogene vav (Protein name ), VAV_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

VAV1(VAV);

Protein name:

Proto-oncogene vav;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2 (By similarity). Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK.

Function:

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

845

Sequence:

50:

MELWRQCTHW | LIQCRVLPPS | HRVTWDGAQV | CELAQALRDG | VLLCQLLNNL |

100:

LPHAINLREV | NLRPQMSQFL | CLKNIRTFLS | TCCEKFGLKR | SELFEAFDLF |

150:

DVQDFGKVIY | TLSALSWTPI | AQNRGIMPFP | TEEESVGDED | IYSGLSDQID |

200:

DTVEEDEDLY | DCVENEEAEG | DEIYEDLMRS | EPVSMPPKMT | EYDKRCCCLR |

250:

EIQQTEEKYT | DTLGSIQQHF | LKPLQRFLKP | QDIEIIFINI | EDLLRVHTHF |

300:

LKEMKEALGT | PGAANLYQVF | IKYKERFLVY | GRYCSQVESA | SKHLDRVAAA |

350:

REDVQMKLEE | CSQRANNGRF | TLRDLLMVPM | QRVLKYHLLL | QELVKHTQEA |

400:

MEKENLRLAL | DAMRDLAQCV | NEVKRDNETL | RQITNFQLSI | ENLDQSLAHY |

450:

GRPKIDGELK | ITSVERRSKM | DRYAFLLDKA | LLICKRRGDS | YDLKDFVNLH |

500:

SFQVRDDSSG | DRDNKKWSHM | FLLIEDQGAQ | GYELFFKTRE | LKKKWMEQFE |

550:

MAISNIYPEN | ATANGHDFQM | FSFEETTSCK | ACQMLLRGTF | YQGYRCHRCR |

600:

ASAHKECLGR | VPPCGRHGQD | FPGTMKKDKL | HRRAQDKKRN | ELGLPKMEVF |

650:

QEYYGLPPPP | GAIGPFLRLN | PGDIVELTKA | EAEQNWWEGR | NTSTNEIGWF |

700:

PCNRVKPYVH | GPPQDLSVHL | WYAGPMERAG | AESILANRSD | GTFLVRQRVK |

750:

DAAEFAISIK | YNVEVKHIKI | MTAEGLYRIT | EKKAFRGLTE | LVEFYQQNSL |

800:

KDCFKSLDTT | LQFPFKEPEK | RTISRPAVGS | TKYFGTAKAR | YDFCARDRSE |

845:

LSLKEGDIIK | ILNKKGQQGW | WRGEIYGRVG | WFPANYVEED | YSEYC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

SMR:

KEGG:

MIM:

STRING:

9606.ENSP00000302269

UniGene:

Pfam:

Uniprot:

FOR

ELISA Kit for Human Proto-oncogene vav

ELISA Kit for Human Proto-oncogene vav

ELISA Kit for Human Proto-oncogene vav

ELISA Kit for Human Proto-oncogene vav

CLIA Kit for Human Proto-oncogene vav

CLIA Kit for Human Proto-oncogene vav

CLIA Kit for Human Proto-oncogene vav

CLIA Kit for Human Proto-oncogene vav

Polyclonal Antibody for Human Proto-oncogene vav

Polyclonal Antibody for Human Proto-oncogene vav

Polyclonal Antibody for Human Proto-oncogene vav

Polyclonal Antibody for Human Proto-oncogene vav

Monoclonal Antibody for Human Proto-oncogene vav

Monoclonal Antibody for Human Proto-oncogene vav

Monoclonal Antibody for Human Proto-oncogene vav

Monoclonal Antibody for Human Proto-oncogene vav

Protein for Human Proto-oncogene vav

Protein for Human Proto-oncogene vav

Protein for Human Proto-oncogene vav

Protein for Human Proto-oncogene vav

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Mechanism of activation of the vav protooncogene."
Coppola J. , Bryant S. , Koda T. , Conway D. , Barbacid M.
Cell Growth Differ.2:95-105(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);MUTAGENESIS OF CYS-529
2.

"Genomic organization and regulation of the vav proto-oncogene."
Denkinger D.J. , Borges C.R. , Butler C.L. , Cushman A.M. , Kawahara R.S.
Biochim. Biophys. Acta1491:253-262(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential."
Katzav S. , Cleveland J.L. , Heslop H.E. , Pulido D.
Mol. Cell. Biol.11:1912-1920(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-61
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-813 (ISOFORM 2)
tissue: Spleen.
6.

"vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells."
Katzav S. , Martin-Zanca D. , Barbacid M.
EMBO J.8:2283-2290(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-845 (ISOFORM 1)
7.

Romero F.
Submitted (1995-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 299-837 (ISOFORM 1)
8.

"The proline-rich region of Vav binds to Grb2 and Grb3-3."
Ramos-Morales F. , Romero F. , Schweighoffer F. , Bismuth G. , Camonis J. , Tortolero M. , Fischer S.
Oncogene11:1665-1669(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 299-334 (ISOFORM 1)
9.

"The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization."
Adams J.M. , Houston H. , Allen J. , Lints T. , Harvey R.
Oncogene7:611-618(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO CDC24 FAMILY
10.

"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product."
Deckert M. , Tartare-Deckert S. , Couture C. , Mustelin T. , Altman A.
Immunity5:591-604(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYK;MUTAGENESIS OF ARG-696
11.

"Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation."
Bustelo X.R. , Crespo P. , Lopez-Barahona M. , Gutkind J.S. , Barbacid M.
Oncogene15:2511-2520(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBLB
12.

"BLNK: a central linker protein in B cell activation."
Fu C. , Turck C.W. , Kurosaki T. , Chan A.C.
Immunity9:93-103(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BLNK; PLCG1; GRB2 AND NCK1
13.

"hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways."
Germani A. , Romero F. , Houlard M. , Camonis J. , Gisselbrecht S. , Fischer S. , Varin-Blank N.
Mol. Cell. Biol.19:3798-3807(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIAH2
14.

"T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase."
Huang J. , Tilly D. , Altman A. , Sugie K. , Grey H.M.
Proc. Natl. Acad. Sci. U.S.A.97:10923-10929(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY FYN
15.

"DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines."
Nishihara H. , Maeda M. , Oda A. , Tsuda M. , Sawa H. , Nagashima K. , Tanaka S.
Blood100:3968-3974(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DOCK2
16.

"Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells."
Lindholm C.K. , Henriksson M.L. , Hallberg B. , Welsh M.
Eur. J. Biochem.269:3279-3288(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
17.

"Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity."
Yabana N. , Shibuya M.
Oncogene21:7720-7729(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APS
18.

"Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton."
Dombroski D. , Houghtling R.A. , Labno C.M. , Precht P. , Takesono A. , Caplen N.J. , Billadeau D.D. , Wange R.L. , Burkhardt J.K. , Schwartzberg P.L.
J. Immunol.174:1385-1392(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITK
19.

"Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor."
Miller S.L. , DeMaria J.E. , Freier D.O. , Riegel A.M. , Clevenger C.V.
Mol. Endocrinol.19:939-949(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEK3
20.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-826;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Characterization of VIK-1: a new Vav-interacting Kruppel-like protein."
Houlard M. , Romero-Portillo F. , Germani A. , Depaux A. , Regnier-Ricard F. , Gisselbrecht S. , Varin-Blank N.
Oncogene24:28-38(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF655/VIK
22.

"A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation."
Gao C. , Blystone S.D.
Biochem. J.420:49-56(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTK2B/PYK2
23.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"Solution structure of the SH2 domain of human proto-oncogene protein VAV1."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 661-775

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