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Index > Protein center > Vav1(Gene name) > Mouse
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  • Vav1 (Gene name),
  • Proto-oncogene vav (Protein name ),  VAV_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Vav1(Vav);
    Protein name:
    Proto-oncogene vav;
    Alternative:
    p95vav;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with SHB (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA, TEC and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. May interact with CCPG1. Interacts with CLNK. Interacts with THEMIS2.Interacts with NEK3 and this interaction is prolactin-dependent. Interacts with ITK.
    Function:
    Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    845
    Sequence:
    50:
    MELWRQCTHW | LIQCRVLPPS | HRVTWEGAQV | CELAQALRDG | VLLCQLLNNL | 
    100:
    LPQAINLREV | NLRPQMSQFL | CLKNIRTFLS | TCCEKFGLKR | SELFEAFDLF | 
    150:
    DVQDFGKVIY | TLSALSWTPI | AQNKGIMPFP | TEDSALNDED | IYSGLSDQID | 
    200:
    DTAEEDEDLY | DCVENEEAEG | DEIYEDLMRL | ESVPTPPKMT | EYDKRCCCLR | 
    250:
    EIQQTEEKYT | DTLGSIQQHF | MKPLQRFLKP | QDMETIFVNI | EELFSVHTHF | 
    300:
    LKELKDALAG | PGATTLYQVF | IKYKERFLVY | GRYCSQVESA | SKHLDQVATA | 
    350:
    REDVQMKLEE | CSQRANNGRF | TLRDLLMVPM | QRVLKYHLLL | QELVKHTQDA | 
    400:
    TEKENLRLAL | DAMRDLAQCV | NEVKRDNETL | RQITNFQLSI | ENLDQSLANY | 
    450:
    GRPKIDGELK | ITSVERRSKT | DRYAFLLDKA | LLICKRRGDS | YDLKASVNLH | 
    500:
    SFQVRDDSSG | ERDNKKWSHM | FLLIEDQGAQ | GYELFFKTRE | LKKKWMEQFE | 
    550:
    MAISNIYPEN | ATANGHDFQM | FSFEETTSCK | ACQMLLRGTF | YQGYRCYRCR | 
    600:
    APAHKECLGR | VPPCGRHGQD | FAGTMKKDKL | HRRAQDKKRN | ELGLPKMEVF | 
    650:
    QEYYGIPPPP | GAFGPFLRLN | PGDIVELTKA | EAEHNWWEGR | NTATNEVGWF | 
    700:
    PCNRVHPYVH | GPPQDLSVHL | WYAGPMERAG | AEGILTNRSD | GTYLVRQRVK | 
    750:
    DTAEFAISIK | YNVEVKHIKI | MTSEGLYRIT | EKKAFRGLLE | LVEFYQQNSL | 
    800:
    KDCFKSLDTT | LQFPYKEPER | RAISKPPAGS | TKYFGTAKAR | YDFCARDRSE | 
    845:
    LSLKEGDIIK | ILNKKGQQGW | WRGEIYGRIG | WFPSNYVEED | YSEYC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Proto-oncogene vav
    ELISA Kit for Mouse Proto-oncogene vav
    ELISA Kit for Mouse Proto-oncogene vav
    ELISA Kit for Mouse Proto-oncogene vav
    CLIA Kit for Mouse Proto-oncogene vav
    CLIA Kit for Mouse Proto-oncogene vav
    CLIA Kit for Mouse Proto-oncogene vav
    CLIA Kit for Mouse Proto-oncogene vav
    Polyclonal Antibody for Mouse Proto-oncogene vav
    Polyclonal Antibody for Mouse Proto-oncogene vav
    Polyclonal Antibody for Mouse Proto-oncogene vav
    Polyclonal Antibody for Mouse Proto-oncogene vav
    Monoclonal Antibody for Mouse Proto-oncogene vav
    Monoclonal Antibody for Mouse Proto-oncogene vav
    Monoclonal Antibody for Mouse Proto-oncogene vav
    Monoclonal Antibody for Mouse Proto-oncogene vav
    Protein for Mouse Proto-oncogene vav
    Protein for Mouse Proto-oncogene vav
    Protein for Mouse Proto-oncogene vav
    Protein for Mouse Proto-oncogene vav

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mechanism of activation of the vav protooncogene."
      Coppola J. , Bryant S. , Koda T. , Conway D. , Barbacid M.
      Cell Growth Differ.2:95-105(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;MUTAGENESIS OF CYS-529; CYS-532 AND HIS-554
    2. 2.
      "The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization."
      Adams J.M. , Houston H. , Allen J. , Lints T. , Harvey R.
      Oncogene7:611-618(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Thymus.
    4. 4.
      "Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential."
      Katzav S. , Cleveland J.L. , Heslop H.E. , Pulido D.
      Mol. Cell. Biol.11:1912-1920(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-93
    5. 5.
      "Tec protein tyrosine kinase is involved in the signaling mechanism of granulocyte colony-stimulating factor receptor."
      Miyazato A. , Yamashita Y. , Hatake K. , Miura Y. , Ozawa K. , Mano H.
      Cell Growth Differ.7:1135-1139(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TEC
    6. 6.
      "Bacterial LPS and IFN-gamma trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase."
      English B.K. , Orlicek S.L. , Mei Z. , Meals E.A.
      J. Leukoc. Biol.62:859-864(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCK;PHOSPHORYLATION
    7. 7.
      "Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling."
      Sosinowski T. , Pandey A. , Dixit V.M. , Weiss A.
      J. Exp. Med.191:463-474(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLA
    8. 8.
      "Cbl-b regulates the CD28 dependence of T-cell activation."
      Chiang Y.J. , Kole H.K. , Brown K. , Naramura M. , Fukuhara S. , Hu R.-J. , Jang I.K. , Gutkind J.S. , Shevach E. , Gu H.
      Nature403:216-220(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH CBLB
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH CBLB
    10. 10.
      "MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT."
      Goitsuka R. , Tatsuno A. , Ishiai M. , Kurosaki T. , Kitamura D.
      J. Biol. Chem.276:36043-36050(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLNK
    11. 11.
      "Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs."
      Kostenko E.V. , Olabisi O.O. , Sahay S. , Rodriguez P.L. , Whitehead I.P.
      Mol. Cell. Biol.26:8964-8975(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE INTERACTION WITH CCPG1
    12. 12.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-844;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    13. 13.
      "Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation."
      Samuels A.L. , Klinken S.P. , Ingley E.
      Blood113:3845-3856(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANKRD54
    14. 14.
      "Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production."
      Peirce M.J. , Brook M. , Morrice N. , Snelgrove R. , Begum S. , Lanfrancotti A. , Notley C. , Hussell T. , Cope A.P. , Wait R.
      PLoS ONE5:E11465-E11465(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THEMIS2
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