FLT1 ELISA Kit for Human(Homo sapiens) | EIAab.comFLT1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FLT1(Gene name) > Human

FLT1 (Gene name),

Vascular endothelial growth factor receptor 1 (Protein name ), VGFR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FLT1(FLT;FRT;VEGFR1);

Protein name:

Vascular endothelial growth factor receptor 1(VEGFR-1);

Alternative:

Tyrosine-protein kinase FRT;Fms-like tyrosine kinase 1(FLT-1);Vascular permeability factor receptor;Tyrosine-protein kinase receptor FLT(FLT);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1. Interacts with GNB2L1/RACK1.

Function:

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform 2 and isoform 3 may have an inhibitory role in angiogenesis.

Subcellular Location:

Isoform 3 Secreted

Protein Attributes:

Sequence length:

1338

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1338:

SEGKRRFTYD | HAELERKIAC | CSPPPDYNSV | VLYSTPPI

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

Pfam:

PF07679

String:

P17948

STRING:

9606.ENSP00000282397

SMR:

P17948

KEGG:

hsa:2321

MIM:

165070

UniGene:

Hs.594454

Uniprot:

P17948

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ELISA Kit for Human VEGFR-1

Cat.:

E0147m

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96T

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ELISA Kit for Human VEGFR-1

Cat.:

E0147r

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96T

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ELISA Kit for Human VEGFR-1

Cat.:

E0147h

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96T

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ELISA Kit for Human VEGFR-1

Cat.:

E0147c

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96T

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CLIA Kit for Human VEGFR-1

Cat.:

U0147h

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96T

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CLIA Kit for Human VEGFR-1

Cat.:

U0147m

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human VEGFR-1

Cat.:

U0147r

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96T

CLIA Kit for Human VEGFR-1

Cat.:

U0147c

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96T

Polyclonal Antibody for Human VEGFR-1

Cat.:

P0147Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human VEGFR-1

Cat.:

P0147Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human VEGFR-1

Cat.:

P0147Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human VEGFR-1

Protein for Human VEGFR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family."
Shibuya M. , Yamaguchi S. , Yamane A. , Ikeda T. , Tojo A. , Matsushime H. , Sato M.
Oncogene5:519-524(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Placenta.
2.

"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor."
Kendall R.L. , Thomas K.A.
Proc. Natl. Acad. Sci. U.S.A.90:10705-10709(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF N-TERMINUS;SUBCELLULAR LOCATION (ISOFORM 2);INTERACTION WITH VEGFA;FUNCTION
tissue: Umbilical vein.
3.

"Characterization of the VEGF binding site on the Flt-1 receptor."
Herley M.T. , Yu Y. , Whitney R.G. , Sato J.D.
Biochem. Biophys. Res. Commun.262:731-738(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VEGFA;GLYCOSYLATION
tissue: Umbilical vein.
4.

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);FUNCTION IN LIGAND BINDING;SUBCELLULAR LOCATION
5.

"A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia."
Sela S. , Itin A. , Natanson-Yaron S. , Greenfield C. , Goldman-Wohl D. , Yagel S. , Keshet E.
Circ. Res.102:1566-1574(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ROLE IN PREECLAMPSIA;INDUCTION
6.

"A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells."
Mezquita B. , Mezquita J. , Pau M. , Mezquita C.
J. Cell. Biochem.110:732-742(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7 AND 8);ALTERNATIVE SPLICING;FUNCTION IN PHOSPHORYLATION OF SRC AND CANCER CELL INVASIVENESS;TISSUE SPECIFICITY
7.

"A new VEGFR1 receptor transcript coding for the extracellular domains of the protein followed by a C-terminal polyserine tail."
Mezquita J. , Mezquita B. , Pau M. , Mezquita C.
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
8.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Placenta.
tissue: Trachea.
10.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Ovary.
13.

"A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13."
Matsushime H. , Yoshida M.C. , Sasaki M. , Shibuya M.
Jpn. J. Cancer Res.78:655-661(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1018-1058;ALTERNATIVE SPLICING (ISOFORM 1)
14.

"Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules."
Ito N. , Wernstedt C. , Engstrom U. , Claesson-Welsh L.
J. Biol. Chem.273:23410-23418(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333;MUTAGENESIS OF TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333;INTERACTION WITH PLCG; GRB2; CRK; NCK1 AND PTPN11
15.

"A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF."
Seetharam L. , Gotoh N. , Maru Y. , Neufeld G. , Yamaguchi S. , Shibuya M.
Oncogene10:135-147(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VEGFA;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;FUNCTION IN PHOSPHORYLATION OF PLCG;ABSENCE OF MITOGENIC FUNCTION IN CULTURED FIBROBLASTS
16.

"Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1."
Barleon B. , Sozzani S. , Zhou D. , Weich H.A. , Mantovani A. , Marme D.
Blood87:3336-3343(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION;FUNCTION IN VEGFA AND PGF SIGNALING;INDUCTION
17.

"The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma."
Sawano A. , Takahashi T. , Yamaguchi S. , Shibuya M.
Biochem. Biophys. Res. Commun.238:487-491(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PLCG AND ACTIVATION OF MAP KINASES;INTERACTION WITH PLCG;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-861 AND TYR-1169;PHOSPHORYLATION AT TYR-1169 AND TYR-1213
18.

"Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."
Igarashi K. , Isohara T. , Kato T. , Shigeta K. , Yamano T. , Uno I.
Biochem. Biophys. Res. Commun.246:95-99(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1; PTPN11 AND NCK1;PHOSPHORYLATION AT TYR-1213
19.

"Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells."
Dunk C. , Ahmed A.
Am. J. Pathol.158:265-273(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NEGATIVE REGULATOR OF KDR-MEDIATED CELL PROLIFERATION
20.

"Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding."
Yu Y. , Hulmes J.D. , Herley M.T. , Whitney R.G. , Crabb J.W. , Sato J.D.
Biochem. J.358:465-472(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1 AND VEGFA;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-1213;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION
21.

"Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor."
Angelucci C. , Lama G. , Iacopino F. , Maglione D. , Sica G.
Growth Factors19:193-206(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PGF-MEDIATED CHORIOCARCINOMA CELL PROLIFERATION
22.

"Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers."
Huang K. , Andersson C. , Roomans G.M. , Ito N. , Claesson-Welsh L.
Int. J. Biochem. Cell Biol.33:315-324(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDR;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;FUNCTION IN VEGFA SIGNALING; PHOSPHORYLATION OF PLCG AND ACTIVATION OF PHOSPHATIDYLINOSITOL KINASE AND PHOSPHOLIPASE C
23.

"Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells."
Cai J. , Ahmad S. , Jiang W.G. , Huang J. , Kontos C.D. , Boulton M. , Ahmed A.
Diabetes52:2959-2968(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SIGNALING VIA ACTIVATION OF THE PHOSPHATIDYLINOSITOL KINASE PATHWAY AND POSITIVE REGULATION OF ANGIOGENESIS IN RESPONSE TO PGF AND VEGFA
24.

"Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1."
Autiero M. , Waltenberger J. , Communi D. , Kranz A. , Moons L. , Lambrechts D. , Kroll J. , Plaisance S. , De Mol M. , Bono F. , Kliche S. , Fellbrich G. , Ballmer-Hofer K. , Maglione D. , Mayr-Beyrle U. , Dewerchin M. , Dombrowski S. , Stanimirovic D. , more...
Nat. Med.9:936-943(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PGF AND KDR;FUNCTION IN PHOSPHORYLATION OF KDR; VEGFA AND PGF SIGNALING;CATALYTIC ACTIVITY;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-1213; TYR-1327 AND TYR-1309
25.

"The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)."
Kobayashi S. , Sawano A. , Nojima Y. , Shibuya M. , Maru Y.
FASEB J.18:929-931(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL AND CD2AP;UBIQUITINATION;AUTOPHOSPHORYLATION IN RESPONSE TO VEGFA;MUTAGENESIS OF TYR-1333;SUBCELLULAR LOCATION
26.

"Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells."
Fan F. , Wey J.S. , McCarty M.F. , Belcheva A. , Liu W. , Bauer T.W. , Somcio R.J. , Wu Y. , Hooper A. , Hicklin D.J. , Ellis L.M.
Oncogene24:2647-2653(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VEGFA AND VEGFB SIGNALING; CANCER CELL MIGRATION; INVASIVENESS AND ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1
27.

"Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases."
Lesslie D.P. , Summy J.M. , Parikh N.U. , Fan F. , Trevino J.G. , Sawyer T.K. , Metcalf C.A. , Shakespeare W.C. , Hicklin D.J. , Ellis L.M. , Gallick G.E.
Br. J. Cancer94:1710-1717(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION AND PHOSPHORYLATION OF PTK2/FAK1; YES1 AND SRC
28.

"A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1."
Meyer R.D. , Mohammadi M. , Rahimi N.
J. Biol. Chem.281:867-875(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-1050
29.

"The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes."
Tchaikovski V. , Fellbrich G. , Waltenberger J.
Arterioscler. Thromb. Vasc. Biol.28:322-328(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PGF AND VEGFA SIGNALING; PHOSPHORYLATION OF AKT1; MAPK3/ERK1 AND MAP KINASES; CHEMOTAXIS AND ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE;AUTOPHOSPHORYLATION IN RESPONSE TO PGF AND VEGFA
30.

"Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt."
Nishi J. , Minamino T. , Miyauchi H. , Nojima A. , Tateno K. , Okada S. , Orimo M. , Moriya J. , Fong G.H. , Sunagawa K. , Shibuya M. , Komuro I.
Circ. Res.103:261-268(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOTHELIAL CELL SURVIVAL AND ANGIOGENESIS
31.

"Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement."
Taylor A.P. , Leon E. , Goldenberg D.M.
Br. J. Cancer103:82-89(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CANCER CELL MIGRATION AND ACTIVATION OF MAPK1/ERK2 AND/OR MAPK3/ERK1
32.

"RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway."
Wang F. , Yamauchi M. , Muramatsu M. , Osawa T. , Tsuchida R. , Shibuya M.
J. Biol. Chem.286:9097-9106(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1
33.

"gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1."
Cai J. , Chen Z. , Ruan Q. , Han S. , Liu L. , Qi X. , Boye S.L. , Hauswirth W.W. , Grant M.B. , Boulton M.E.
J. Biol. Chem.286:42514-42523(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSEN1 AND PTPRB;DEPHOSPHORYLATION BY PTPRB;MUTAGENESIS OF VAL-767;PROTEOLYTIC CLEAVAGE BY PSEN1 AT VAL-767
34.

"Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis."
Ahmad S. , Hewett P.W. , Al-Ani B. , Sissaoui S. , Fujisawa T. , Cudmore M.J. , Ahmed A.
Vasc. Cell3:15-15(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DECOY RECEPTORS; REGULATION OF VEGFA SIGNALING AND REGULATION OF KDR ACTIVITY (ISOFORMS 2/3/4);ROLE IN PREECLAMPSIA
35.

"Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis."
Shibuya M.
J. Biochem. Mol. Biol.39:469-478(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION AS NEGATIVE REGULATOR OF ANGIOGENESIS DURING EMBRYONIC DEVELOPMENT; POSITIVE REGULATION OF MACROPHAGE FUNCTION IN ADULTHOOD; ROLE IN CARCINOGENESIS AND INFLAMMATION
36.

"VEGF receptor protein-tyrosine kinases: structure and regulation."
Roskoski R. Jr.
Biochem. Biophys. Res. Commun.375:287-291(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON STRUCTURE AND FUNCTION
37.

"VEGFs and receptors involved in angiogenesis versus lymphangiogenesis."
Lohela M. , Bry M. , Tammela T. , Alitalo K.
Curr. Opin. Cell Biol.21:154-165(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN ANGIOGENESIS AND CANCER
38.

"Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling."
Grunewald F.S. , Prota A.E. , Giese A. , Ballmer-Hofer K.
Biochim. Biophys. Acta1804:567-580(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
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"Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1)."
Schwartz J.D. , Rowinsky E.K. , Youssoufian H. , Pytowski B. , Wu Y.
Cancer116:1027-1032(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN CANCER
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"Signal transduction by vascular endothelial growth factor receptors."
Koch S. , Tugues S. , Li X. , Gualandi L. , Claesson-Welsh L.
Biochem. J.437:169-183(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
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"Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia."
Shibuya M.
Proc. Jpn. Acad., B, Phys. Biol. Sci.87:167-178(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN CANCER AND PREECLAMPSIA
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"Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor."
Wiesmann C. , Fuh G. , Christinger H.W. , Eigenbrot C. , Wells J.A. , de Vos A.M.
Cell91:695-704(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 132-226 IN COMPLEX WITH VEGFA;DOMAIN
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"Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states."
Starovasnik M.A. , Christinger H.W. , Wiesmann C. , Champe M.A. , de Vos A.M. , Skelton N.J.
J. Mol. Biol.293:531-544(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 129-229;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 129-229 IN COMPLEX WITH VEGFA;SUBUNIT;INTERACTION WITH VEGFA
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"The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1."
Christinger H.W. , Fuh G. , de Vos A.M. , Wiesmann C.
J. Biol. Chem.279:10382-10388(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 130-229 IN COMPLEX WITH PGF
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"Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity."
Iyer S. , Darley P.I. , Acharya K.R.
J. Biol. Chem.285:23779-23789(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 129-226 IN COMPLEX WITH VEGFB;INTERACTION WITH VEGFB;SUBUNIT;DOMAIN
46.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-60; LYS-144; GLN-281; ILE-422; GLN-781; VAL-938; ALA-982 AND VAL-1061

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