KDR ELISA Kit for Human(Homo sapiens) | EIAab.comKDR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > KDR(Gene name) > Human

KDR (Gene name),

Vascular endothelial growth factor receptor 2 (Protein name ), VGFR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KDR(FLK1;VEGFR2);

Protein name:

Vascular endothelial growth factor receptor 2(VEGFR-2);

Alternative:

Kinase insert domain receptor(KDR);Fetal liver kinase 1(FLK-1);Protein-tyrosine kinase receptor flk-1;

CD:

CD309;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MYOF (By similarity). Interacts with SHB; upon VEGF activation. Interacts with HIV-1 Tat.

Function:

Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1356

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1356:

LSSPPV

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000263923

String:

P35968

KEGG:

hsa:3791

MIM:

191306

Pfam:

PF07679

SMR:

P35968

UniGene:

Hs.479756

Uniprot:

P35968

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ELISA Kit for Human VEGFR-2

Cat.:

E0148h

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Manual:

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Packing:

96T

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ELISA Kit for Human VEGFR-2

Cat.:

E0148r

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Packing:

96T

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ELISA Kit for Human VEGFR-2

Cat.:

E0148m

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96T

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CLIA Kit for Human VEGFR-2

Cat.:

U0148m

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human VEGFR-2

Cat.:

U0148r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human VEGFR-2

Cat.:

U0148h

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Packing:

96T

Polyclonal Antibody for Human VEGFR-2

Cat.:

P0148Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human VEGFR-2

Cat.:

P0148Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human VEGFR-2

Cat.:

P0148Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human VEGFR-2

Protein for Human VEGFR-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);INTERACTION WITH VEGFC;SUBCELLULAR LOCATION
2.

"Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth."
Albuquerque R.J. , Hayashi T. , Cho W.G. , Kleinman M.E. , Dridi S. , Takeda A. , Baffi J.Z. , Yamada K. , Kaneko H. , Green M.G. , Chappell J. , Wilting J. , Weich H.A. , Yamagami S. , Amano S. , Mizuki N. , Alexander J.S. , Peterson M.L. , more...
Nat. Med.15:1023-1030(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION IN INHIBITION OF LYMPHANGIOGENESIS;INTERACTION WITH VEGFC;TISSUE SPECIFICITY
3.

"Full length human KDR/flk-1 sequence."
Yin L.Y. , Wu Y. , Patterson C.
Submitted (1997-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Coding region for human VEGF receptor KDR (VEGFR-2)."
Yu Y. , Whitney R.G. , Sato J.D.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Umbilical vein.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT HIS-472
7.

"Identification of a new endothelial cell growth factor receptor tyrosine kinase."
Terman B.I. , Carrion M.E. , Kovacs E. , Rasmussen B.A. , Eddy R.L. , Shows T.B.
Oncogene6:1677-1683(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-1356 (ISOFORM 1);VARIANT GLU-848
tissue: Umbilical vein.
8.

"Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor."
Patterson C. , Perrella M.A. , Hsieh C.-M. , Yoshizumi M. , Lee M.-E. , Harber E.
J. Biol. Chem.270:23111-23118(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
9.

"Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor."
Terman B.I. , Dougher-Vermazen M. , Carrion M.E. , Dimitrov D. , Armellino D.C. , Gospodarowicz D. , Boehlen P.
Biochem. Biophys. Res. Commun.187:1579-1586(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH VEGFA
10.

"Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor."
Waltenberger J. , Claesson-Welsh L. , Siegbahn A. , Shibuya M. , Heldin C.H.
J. Biol. Chem.269:26988-26995(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS VEGFA RECEPTOR; IN REGULATION OF CELL SHAPE; ACTIN CYTOSKELETON REORGANIZATION; CELL MIGRATION AND CELL PROLIFERATION;AUTOPHOSPHORYLATION
11.

"The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts."
Takahashi T. , Shibuya M.
Oncogene14:2079-2089(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VEGFA SIGNALING; PHOSPHORYLATION OF PLCG1; ACTIVATION OF MAP KINASES AND IN PROMOTING PROLIFERATION OF ENDOTHELIAL CELLS;INTERACTION WITH VEGFA AND PLCG1;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION;GLYCOSYLATION
12.

"VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR)."
Kroll J. , Waltenberger J.
Biochem. Biophys. Res. Commun.252:743-746(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INDUCTION OF NOS2 AND NOS3
13.

"Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation."
Gerber H.P. , McMurtrey A. , Kowalski J. , Yan M. , Keyt B.A. , Dixit V. , Ferrara N.
J. Biol. Chem.273:30336-30343(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF THE PHOSPHATIDYLINOSITOL 3-KINASE AND AKT1 SIGNALING PATHWAY
14.

"A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells."
Kroll J. , Waltenberger J.
Biochem. Biophys. Res. Commun.265:636-639(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NITRIC OXIDE RELEASE
15.

"Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues."
Kendall R.L. , Rutledge R.Z. , Mao X. , Tebben A.J. , Hungate R.W. , Thomas K.A.
J. Biol. Chem.274:6453-6460(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;CHARACTERIZATION OF VARIANT GLU-848;PHOSPHORYLATION AT TYR-1054 AND TYR-1059;ENZYME REGULATION
16.

"Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization."
Dougher M. , Terman B.I.
Oncogene18:1619-1627(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PLCG1 AND PTK2/FAK1;INTERACTION WITH VEGFA;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-996; TYR-1054 AND TYR-1059;MUTAGENESIS OF TYR-996; TYR-1054 AND TYR-1059;SUBCELLULAR LOCATION;ENZYME REGULATION
17.

"Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells."
Mitola S. , Soldi R. , Zanon I. , Barra L. , Gutierrez M.I. , Berkhout B. , Giacca M. , Bussolino F.
J. Virol.74:344-353(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV-1 TAT
18.

"A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells."
Takahashi T. , Yamaguchi S. , Chida K. , Shibuya M.
EMBO J.20:2768-2778(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOTHELIAL CELL PROLIFERATION; PHOSPHORYLATION OF PLCG1 AND ACTIVATION OF MAP KINASES;PHOSPHORYLATION AT TYR-1175 AND TYR-1214;MUTAGENESIS OF LYS-868 AND TYR-1175
19.

"Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells."
Duval M. , Bedard-Goulet S. , Delisle C. , Gratton J.P.
J. Biol. Chem.278:20091-20097(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;FUNCTION IN NITRIC OXIDE PRODUCTION;SUBCELLULAR LOCATION;INTERACTION WITH CBL
20.

"Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites."
Dixelius J. , Makinen T. , Wirzenius M. , Karkkainen M.J. , Wernstedt C. , Alitalo K. , Claesson-Welsh L.
J. Biol. Chem.278:40973-40979(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLT4
21.

"The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration."
Holmqvist K. , Cross M.J. , Rolny C. , Haegerkvist R. , Rahimi N. , Matsumoto T. , Claesson-Welsh L. , Welsh M.
J. Biol. Chem.279:22267-22275(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB;FUNCTION IN CELL MIGRATION
22.

"Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus."
Fox S.B. , Turley H. , Cheale M. , Blazquez C. , Roberts H. , James N. , Cook N. , Harris A. , Gatter K.
J. Pathol.202:313-320(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION
23.

"Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells."
Jia H. , Bagherzadeh A. , Bicknell R. , Duchen M.R. , Liu D. , Zachary I.
J. Biol. Chem.279:36148-36157(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VEGFA AND VEGFD;PHOSPHORYLATION AT TYR-1054 AND TYR-1059;FUNCTION IN VEGFA AND VEGFD SIGNALING; ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1; ACTIVATION OF AKT1; PHOSPHORYLATION OF PLCG1 AND NOS3; MODULATION OF INTRACELLULAR CA(2+) LEVELS; CELL SURVIVAL AND POSITIVE REGULATION OF CELL PROLIFERATION; CELL MIGRATION AND ANGIOGENESIS;ENZYME REGULATION
24.

"VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis."
Matsumoto T. , Bohman S. , Dixelius J. , Berge T. , Dimberg A. , Magnusson P. , Wang L. , Wikner C. , Qi J.H. , Wernstedt C. , Wu J. , Bruheim S. , Mugishima H. , Mukhopadhyay D. , Spurkland A. , Claesson-Welsh L.
EMBO J.24:2342-2353(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION; PHOSPHORYLATION OF PLCG1; ACTIVATION OF MAPK1/ERK2; MAPK3/ERK1 AND THE MAP KINASES AND IN REGULATION OF ACTIN CYTOSKELETON REORGANIZATION;INTERACTION WITH SH2D2A/TSAD;PHOSPHORYLATION AT TYR-951; TYR-1054; TYR-1059; TYR-1214; TYR-1305; TYR-1309 AND TYR-1319;MUTAGENESIS OF TYR-951
25.

"Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF."
Lamalice L. , Houle F. , Huot J.
J. Biol. Chem.281:34009-34020(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOTHELIAL CELL MIGRATION; ACTIVATION OF MAP KINASES AND IN PHOSPHORYLATION OF FYN; SRC AND NCK1;INTERACTION WITH GRB2; FYN AND NCK1;MUTAGENESIS OF TYR-1214
26.

"Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells."
Ewan L.C. , Jopling H.M. , Jia H. , Mittar S. , Bagherzadeh A. , Howell G.J. , Walker J.H. , Zachary I.C. , Ponnambalam S.
Traffic7:1270-1282(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;UBIQUITINATION;DEGRADATION
27.

"Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells."
Blanes M.G. , Oubaha M. , Rautureau Y. , Gratton J.P.
J. Biol. Chem.282:10660-10669(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ACTIVATION OF AKT1; PHOSPHORYLATION OF PLCG1 AND NOS3 AND REGULATION OF NITRIC OXIDE PRODUCTION;PHOSPHORYLATION AT TYR-801;MUTAGENESIS OF TYR-801
28.

"AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice."
Zhang H. , He Y. , Dai S. , Xu Z. , Luo Y. , Wan T. , Luo D. , Jones D. , Tang S. , Chen H. , Sessa W.C. , Min W.
J. Clin. Invest.118:3904-3916(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2IP
29.

"Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis."
Mellberg S. , Dimberg A. , Bahram F. , Hayashi M. , Rennel E. , Ameur A. , Westholm J.O. , Larsson E. , Lindahl P. , Cross M.J. , Claesson-Welsh L.
FASEB J.23:1490-1502(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-951; TYR-1175 AND TYR-1214;DEPHOSPHORYLATION BY PTPRB
30.

"New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival."
Chabot C. , Spring K. , Gratton J.P. , Elchebly M. , Royal I.
Mol. Cell. Biol.29:241-253(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-801; TYR-951; TYR-996; TYR-1054; TYR-1059; TYR-1175 AND TYR-1214; DEPHOSPHORYLATION AT TYR-951; TYR-996; TYR-1054; TYR-1059; TYR-1175 AND TYR-1214 BY PTPRJ
31.

"VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2."
Zhang Z. , Neiva K.G. , Lingen M.W. , Ellis L.M. , Nor J.E.
Cell Death Differ.17:499-512(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS VEGFA RECEPTOR IN TUMOR ANGIOGENESIS;SUBCELLULAR LOCATION;UBIQUITINATION
32.

"Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2."
Becker J. , Pavlakovic H. , Ludewig F. , Wilting F. , Weich H.A. , Albuquerque R. , Ambati J. , Wilting J.
Clin. Cancer Res.16:1431-1441(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LYMPHANGIOGENESIS (ISOFORM 2)
33.

"VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts."
Nilsson I. , Bahram F. , Li X. , Gualandi L. , Koch S. , Jarvius M. , Soderberg O. , Anisimov A. , Kholova I. , Pytowski B. , Baldwin M. , Yla-Herttuala S. , Alitalo K. , Kreuger J. , Claesson-Welsh L.
EMBO J.29:1377-1388(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VEGFC AND FLT4;SUBCELLULAR LOCATION;FUNCTION IN ANGIOGENESIS
34.

"The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling."
Jopling H.M. , Howell G.J. , Gamper N. , Ponnambalam S.
Biochem. Biophys. Res. Commun.410:170-176(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
35.

"Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis."
Nakao S. , Zandi S. , Hata Y. , Kawahara S. , Arita R. , Schering A. , Sun D. , Melhorn M.I. , Ito Y. , Lara-Castillo N. , Ishibashi T. , Hafezi-Moghadam A.
Blood117:1081-1090(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LYMPHANGIOGENESIS;INTERACTION WITH FLT4 AND VEGFC
36.

"Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis."
Shibuya M.
J. Biochem. Mol. Biol.39:469-478(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN ANGIOGENESIS
37.

"Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition."
Holmes K. , Roberts O.L. , Thomas A.M. , Cross M.J.
Cell. Signal.19:2003-2012(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
38.

"VEGF receptor protein-tyrosine kinases: structure and regulation."
Roskoski R. Jr.
Biochem. Biophys. Res. Commun.375:287-291(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON STRUCTURE AND FUNCTION
39.

"VEGFs and receptors involved in angiogenesis versus lymphangiogenesis."
Lohela M. , Bry M. , Tammela T. , Alitalo K.
Curr. Opin. Cell Biol.21:154-165(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN ANGIOGENESIS AND CANCER
40.

"Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling."
Grunewald F.S. , Prota A.E. , Giese A. , Ballmer-Hofer K.
Biochim. Biophys. Acta1804:567-580(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
41.

"Vascular endothelial growth factor receptor-2 in breast cancer."
Guo S. , Colbert L.S. , Fuller M. , Zhang Y. , Gonzalez-Perez R.R.
Biochim. Biophys. Acta1806:108-121(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN ANGIOGENESIS AND CANCER
42.

"Tyrosine kinase receptor Flt/VEGFR family: its characterization related to angiogenesis and cancer."
Shibuya M.
Genes Cancer1:1119-1123(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN ANGIOGENESIS AND CANCER
43.

"Signal transduction by vascular endothelial growth factor receptors."
Koch S. , Tugues S. , Li X. , Gualandi L. , Claesson-Welsh L.
Biochem. J.437:169-183(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
44.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-982 AND SER-984;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
45.

"Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2."
Rho S.B. , Song Y.J. , Lim M.C. , Lee S.H. , Kim B.R. , Park S.Y.
Cell. Signal.24:131-139(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PDCD6
46.

"VEGFR2 functions as an H(2)S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells."
Tao B.B. , Liu S.Y. , Zhang C.C. , Fu W. , Cai W.J. , Wang Y. , Shen Q. , Wang M.J. , Chen Y. , Zhang L.J. , Zhu Y.Z. , Zhu Y.C.
Antioxid. Redox Signal.19:448-464(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;REDOX-ACTIVE DISULFIDE BOND;MUTAGENESIS OF CYS-1045
47.

"Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis."
McTigue M.A. , Wickersham J.A. , Pinko C. , Showalter R.E. , Parast C.V. , Tempczyk-Russell A. , Gehring M.R. , Mroczkowski B. , Kan C.-C. , Villafranca J.E. , Appelt K.
Structure7:319-330(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 806-1171;FUNCTION;PHOSPHORYLATION AT TYR-1059;IDENTIFICATION BY MASS SPECTROMETRY
48.

"Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors."
Miyazaki Y. , Matsunaga S. , Tang J. , Maeda Y. , Nakano M. , Philippe R.J. , Shibahara M. , Liu W. , Sato H. , Wang L. , Nolte R.T.
Bioorg. Med. Chem. Lett.15:2203-2207(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) OF 806-1171 IN COMPLEX WITH SYNTHETIC INHIBITOR
49.

"Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor."
Hodous B.L. , Geuns-Meyer S.D. , Hughes P.E. , Albrecht B.K. , Bellon S. , Bready J. , Caenepeel S. , Cee V.J. , Chaffee S.C. , Coxon A. , Emery M. , Fretland J. , Gallant P. , Gu Y. , Hoffman D. , Johnson R.E. , Kendall R. , Kim J.L. , more...
J. Med. Chem.50:611-626(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 815-1171 IN COMPLEX WITH SYNTHETIC INHIBITOR
50.

"Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors."
Peifer C. , Selig R. , Kinkel K. , Ott D. , Totzke F. , Schaechtele C. , Heidenreich R. , Roecken M. , Schollmeyer D. , Laufer S.
J. Med. Chem.51:3814-3824(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 806-1171 IN COMPLEX WITH SYNTHETIC INHIBITOR;FUNCTION
51.

"Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling."
Yang Y. , Xie P. , Opatowsky Y. , Schlessinger J.
Proc. Natl. Acad. Sci. U.S.A.107:1906-1911(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 657-764;SUBUNIT;AUTOPHOSPHORYLATION;FUNCTION IN VEGFA SIGNALING AND ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1;MUTAGENESIS OF ARG-726 AND ASP-731
52.

"Structural determinants of growth factor binding and specificity by VEGF receptor 2."
Leppanen V.M. , Prota A.E. , Jeltsch M. , Anisimov A. , Kalkkinen N. , Strandin T. , Lankinen H. , Goldman A. , Ballmer-Hofer K. , Alitalo K.
Proc. Natl. Acad. Sci. U.S.A.107:2425-2430(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 120-326 IN COMPLEX WITH VEGFC;INTERACTION WITH VEGFC;DOMAIN;DISULFIDE BONDS;GLYCOSYLATION AT ASN-143; ASN-245 AND ASN-318
53.

"The structural basis for the function of two anti-VEGF receptor 2 antibodies."
Franklin M.C. , Navarro E.C. , Wang Y. , Patel S. , Singh P. , Zhang Y. , Persaud K. , Bari A. , Griffith H. , Shen L. , Balderes P. , Kussie P.
Structure19:1097-1107(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 220-338 IN COMPLEX WITH ANTIBODY FRAGMENT;DISULFIDE BOND;GLYCOSYLATION AT ASN-245 AND ASN-318
54.

"Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma."
Walter J.W. , North P.E. , Waner M. , Mizeracki A. , Blei F. , Walker J.W.T. , Reinisch J.F. , Marchuk D.A.
Genes Chromosomes Cancer33:295-303(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HCI SER-1147
55.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-275 AND ARG-873
56.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-2; MET-136; GLY-248; ILE-297; VAL-462; HIS-472; ARG-482; ARG-539; MET-689; ASN-814 AND THR-1065
57.

"Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma."
Jinnin M. , Medici D. , Park L. , Limaye N. , Liu Y. , Boscolo E. , Bischoff J. , Vikkula M. , Boye E. , Olsen B.R.
Nat. Med.14:1236-1246(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HCI SUSCEPTIBILITY ARG-482

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