GGCX ELISA Kit for Human(Homo sapiens) | EIAab.comGGCX ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GGCX(Gene name) > Human

GGCX (Gene name),

Vitamin K-dependent gamma-carboxylase (Protein name ), VKGC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GGCX(GC);

Protein name:

Vitamin K-dependent gamma-carboxylase;

Alternative:

Peptidyl-glutamate 4-carboxylase;Gamma-glutamyl carboxylase;Vitamin K gamma glutamyl carboxylase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. May interact with CALU.

Function:

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

758

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

758:

PDPVHSEF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.77719

MIM:

137167

Pfam:

PF05090

STRING:

9606.ENSP00000233838

UniGene:

Hs.592466

String:

P38435

KEGG:

hsa:2677

Uniprot:

P38435

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ELISA Kit for Human Vitamin K-dependent gamma-carboxylase

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ELISA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

E15387h

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Manual:

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96T

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ELISA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

E15387b

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Packing:

96T

ELISA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

E15387m

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96T

CLIA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

U15387b

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MSDS:

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Packing:

96T

CLIA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

U15387m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

U15387r

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96T

CLIA Kit for Human Vitamin K-dependent gamma-carboxylase

Cat.:

U15387h

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Packing:

96T

Polyclonal Antibody for Human Vitamin K-dependent gamma-carboxylase

Cat.:

P15387Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Vitamin K-dependent gamma-carboxylase

Cat.:

P15387Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Vitamin K-dependent gamma-carboxylase

Cat.:

P15387Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Vitamin K-dependent gamma-carboxylase

Monoclonal Antibody for Human Vitamin K-dependent gamma-carboxylase

Protein for Human Vitamin K-dependent gamma-carboxylase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and expression of the cDNA for human gamma-glutamyl carboxylase."
Wu S.-M. , Cheung W.-F. , Frazier D. , Stafford D.W.
Science254:1634-1636(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLN-325
2.

"Genomic sequence and transcription start site for the human gamma-glutamyl carboxylase."
Wu S.-M. , Stafford D.W. , Frazier L.D. , Fu Y.Y. , High K.A. , Chu K. , Sanchez-Vega B. , Solera J.
Blood89:4058-4062(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Ying L. , Lipsky J.J.
Submitted (1996-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
7.

"A topological study of the human gamma-glutamyl carboxylase."
Tie J. , Wu S.-M. , Jin D. , Nicchitta C.V. , Stafford D.W.
Blood96:973-978(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TOPOLOGY
8.

"A novel fluorescence assay to study propeptide interaction with gamma-glutamyl carboxylase."
Presnell S.R. , Tripathy A. , Lentz B.R. , Jin D.Y. , Stafford D.W.
Biochemistry40:11723-11733(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROPEPTIDE INTERACTION;MONOMER
9.

"Determination of disulfide bond assignment of human vitamin K-dependent gamma-glutamyl carboxylase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry."
Tie J.K. , Mutucumarana V.P. , Straight D.L. , Carrick K.L. , Pope R.M. , Stafford D.W.
J. Biol. Chem.278:45468-45475(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BOND
10.

"The vitamin K-dependent carboxylase."
Berkner K.L.
Annu. Rev. Nutr.25:127-149(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation."
Rishavy M.A. , Hallgren K.W. , Yakubenko A.V. , Shtofman R.L. , Runge K.W. , Berkner K.L.
Biochemistry45:13239-13248(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF HIS-160; LYS-218; HIS-287 AND HIS-381;ACTIVE SITE;FUNCTION;PH DEPENDENCE;REACTION MECHANISM
12.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
13.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-459 AND ASN-550
tissue: Liver.
14.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"A missense mutation in gamma-glutamyl carboxylase gene causes combined deficiency of all vitamin K-dependent blood coagulation factors."
Brenner B. , Sanchez-Vega B. , Wu S.M. , Lanir N. , Stafford D.W. , Solera J.
Blood92:4554-4559(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VKCFD1 ARG-394
16.

"Novel mutation in the gamma-glutamyl carboxylase gene resulting in congenital combined deficiency of all vitamin K-dependent blood coagulation factors."
Spronk H.M.H. , Farah R.A. , Buchanan G.R. , Vermeer C. , Soute B.A.M.
Blood96:3650-3652(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VKCFD1 SER-501
17.

"Expression and characterization of the naturally occurring mutation L394R in human gamma-glutamyl carboxylase."
Mutucumarana V.P. , Stafford D.W. , Stanley T.B. , Jin D.-Y. , Solera J. , Brenner B. , Azerad R. , Wu S.-M.
J. Biol. Chem.275:32572-32577(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT VKCFD1 ARG-394
18.

"Compound heterozygous mutations in the gamma-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors."
Rost S. , Fregin A. , Koch D. , Compes M. , Mueller C.R. , Oldenburg J.
Br. J. Haematol.126:546-549(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VKCFD1 PRO-485
19.

"Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity."
Vanakker O.M. , Martin L. , Gheduzzi D. , Leroy B.P. , Loeys B.L. , Guerci V.I. , Matthys D. , Terry S.F. , Coucke P.J. , Pasquali-Ronchetti I. , De Paepe A.
J. Invest. Dermatol.127:581-587(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PXEL-MCFD SER-299; CYS-476; HIS-476; SER-493 AND ARG-558

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