Gene name:
VPS35 (TCCCTA00141;MEM3) ;
Protein name:
Vacuolar protein sorting-associated protein 35 (hVPS35) ;
Alternative:
Vesicle protein sorting 35 ;Maternal-embryonic 3 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS26A and VPS26B. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GOLPH3.
Function:
Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
Subcellular Location:
Cytoplasm
Membrane
Peripheral membrane protein
Protein Attributes:
50:
MPTTQQSPQD | EQEKLLDEAI | QAVKVQSFQM | KRCLDKNKLM | DALKHASNML |
100:
GELRTSMLSP | KSYYELYMAI | SDELHYLEVY | LTDEFAKGRK | VADLYELVQY |
150:
AGNIIPRLYL | LITVGVVYVK | SFPQSRKDIL | KDLVEMCRGV | QHPLRGLFLR |
200:
NYLLQCTRNI | LPDEGEPTDE | ETTGDISDSM | DFVLLNFAEM | NKLWVRMQHQ |
250:
GHSRDREKRE | RERQELRILV | GTNLVRLSQL | EGVNVERYKQ | IVLTGILEQV |
300:
VNCRDALAQE | YLMECIIQVF | PDEFHLQTLN | PFLRACAELH | QNVNVKNIII |
350:
ALIDRLALFA | HREDGPGIPA | DIKLFDIFSQ | QVATVIQSRQ | DMPSEDVVSL |
400:
QVSLINLAMK | CYPDRVDYVD | KVLETTVEIF | NKLNLEHIAT | SSAVSKELTR |
450:
LLKIPVDTYN | NILTVLKLKH | FHPLFEYFDY | ESRKSMSCYV | LSNVLDYNTE |
500:
IVSQDQVDSI | MNLVSTLIQD | QPDQPVEDPD | PEDFADEQSL | VGRFIHLLRS |
550:
EDPDQQYLIL | NTARKHFGAG | GNQRIRFTLP | PLVFAAYQLA | FRYKENSKVD |
600:
DKWEKKCQKI | FSFAHQTISA | LIKAELAELP | LRLFLQGALA | AGEIGFENHE |
650:
TVAYEFMSQA | FSLYEDEISD | SKAQLAAITL | IIGTFERMKC | FSEENHEPLR |
700:
TQCALAASKL | LKKPDQGRAV | STCAHLFWSG | RNTDKNGEEL | HGGKRVMECL |
750:
KKALKIANQC | MDPSLQVQLF | IEILNRYIYF | YEKENDAVTI | QVLNQLIQKI |
796:
REDLPNLESS | EETEQINKHF | HNTLEHLRLR | RESPESEGPI | YEGLIL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
ELISA Kit for Human hVPS35
ELISA Kit for Human hVPS35
ELISA Kit for Human hVPS35
CLIA Kit for Human hVPS35
CLIA Kit for Human hVPS35
CLIA Kit for Human hVPS35
Polyclonal Antibody for Human hVPS35
Polyclonal Antibody for Human hVPS35
Polyclonal Antibody for Human hVPS35
Monoclonal Antibody for Human hVPS35
Monoclonal Antibody for Human hVPS35
Monoclonal Antibody for Human hVPS35
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Lung .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Testis .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Pheochromocytoma .
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Ileal mucosa .
tissue :
Placenta .
tissue :
Teratocarcinoma .
6.
"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Placenta .
tissue :
Prostate .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-796
tissue :
Leukemia .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH IGF2R
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EHD1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RAB7A
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Nature459:1085-1090(2009)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GOLPH3
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
16.
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Sci. Signal.3:RA3-RA3(2010)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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"A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."
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Nat. Cell Biol.13:914-923(2011)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF THE SNX3-RETROMER;SUBUNIT
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH FAM21C; FKBP15 AND WASH1
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH FAM21C
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH VPS29 AND VPS26;MUTAGENESIS OF LEU-108 AND HIS-675
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MAGEL2
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF THE SNX27-RETROMER;SUBUNIT;INTERACTION WITH SNX27 AND KIAA0196
24.
"RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
MacLeod D.A.
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Neuron77:425-439(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN RETROGRADE TRANSPORT;INTERACTION WITH LRRK2;CHARACTERIZATION OF VARIANT PARK17 ASN-620
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNX3 AND SLC11A2
26.
"Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation."
McGough I.J.
,
Steinberg F.
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Jia D.
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Barbuti P.A.
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McMillan K.J.
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Heesom K.J.
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Whone A.L.
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Caldwell M.A.
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Cullen P.J.
Curr. Biol.24:1670-1676(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH FAM21C;CHARACTERIZATION OF VARIANT PARK17 ASN-620
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CHARACTERIZATION OF VARIANT PARK17 ASN-620
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 483-780 IN COMPLEX WITH VPS29;ELECTRON MICROSCOPY OF THE RETROMER COMPLEX CONTAINING VPS29; VPS35 AND VPS26
29.
"VPS35 mutations in Parkinson disease."
Vilarino-Guell C.
,
Wider C.
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Ross O.A.
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Dachsel J.C.
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Kachergus J.M.
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Lincoln S.J.
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Soto-Ortolaza A.I.
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Cobb S.A.
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Wilhoite G.J.
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Melrose H.L.
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Am. J. Hum. Genet.89:162-167(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT PARK17 ASN-620;VARIANTS SER-316 AND VAL-737
30.
"A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease."
Zimprich A.
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Benet-Pages A.
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Struhal W.
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Graf E.
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Eck S.H.
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Offman M.N.
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Haubenberger D.
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,
Rossle S.C.
,
Klopp N.
,
Wolf E.
,
Seppi K.
,
Pirker W.
,
Reinthaler E.
,
Harutyunyan A.
,
Kralovics R.
,
Peters A.
,
Zimprich F.
,
Brucke T.
,
Poewe W.
,
Auff E.
,
Trenkwalder C.
,
Rost B.
,
Ransmayr G.
,
Winkelmann J.
,
Meitinger T.
,
Strom T.M.
more...
Am. J. Hum. Genet.89:168-175(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT PARK17 ASN-620;VARIANTS SER-51; ILE-57; ARG-82; MET-241; TRP-524 AND MET-774
31.
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Cited for : VARIANT PARK17 ASN-620