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Index > Protein center > VPS35(Gene name) > Human
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  • VPS35 (Gene name),
  • Vacuolar protein sorting-associated protein 35 (Protein name ),  VPS35_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    VPS35(TCCCTA00141;MEM3);
    Protein name:
    Vacuolar protein sorting-associated protein 35(hVPS35);
    Alternative:
    Vesicle protein sorting 35;Maternal-embryonic 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Interacts directly with VPS26A and VPS26B. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GOLPH3.
    Function:
    Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA).
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    796
    Sequence:
    50:
    MPTTQQSPQD | EQEKLLDEAI | QAVKVQSFQM | KRCLDKNKLM | DALKHASNML | 
    100:
    GELRTSMLSP | KSYYELYMAI | SDELHYLEVY | LTDEFAKGRK | VADLYELVQY | 
    150:
    AGNIIPRLYL | LITVGVVYVK | SFPQSRKDIL | KDLVEMCRGV | QHPLRGLFLR | 
    200:
    NYLLQCTRNI | LPDEGEPTDE | ETTGDISDSM | DFVLLNFAEM | NKLWVRMQHQ | 
    250:
    GHSRDREKRE | RERQELRILV | GTNLVRLSQL | EGVNVERYKQ | IVLTGILEQV | 
    300:
    VNCRDALAQE | YLMECIIQVF | PDEFHLQTLN | PFLRACAELH | QNVNVKNIII | 
    350:
    ALIDRLALFA | HREDGPGIPA | DIKLFDIFSQ | QVATVIQSRQ | DMPSEDVVSL | 
    400:
    QVSLINLAMK | CYPDRVDYVD | KVLETTVEIF | NKLNLEHIAT | SSAVSKELTR | 
    450:
    LLKIPVDTYN | NILTVLKLKH | FHPLFEYFDY | ESRKSMSCYV | LSNVLDYNTE | 
    500:
    IVSQDQVDSI | MNLVSTLIQD | QPDQPVEDPD | PEDFADEQSL | VGRFIHLLRS | 
    550:
    EDPDQQYLIL | NTARKHFGAG | GNQRIRFTLP | PLVFAAYQLA | FRYKENSKVD | 
    600:
    DKWEKKCQKI | FSFAHQTISA | LIKAELAELP | LRLFLQGALA | AGEIGFENHE | 
    650:
    TVAYEFMSQA | FSLYEDEISD | SKAQLAAITL | IIGTFERMKC | FSEENHEPLR | 
    700:
    TQCALAASKL | LKKPDQGRAV | STCAHLFWSG | RNTDKNGEEL | HGGKRVMECL | 
    750:
    KKALKIANQC | MDPSLQVQLF | IEILNRYIYF | YEKENDAVTI | QVLNQLIQKI | 
    796:
    REDLPNLESS | EETEQINKHF | HNTLEHLRLR | RESPESEGPI | YEGLIL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    SMR:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human hVPS35
    ELISA Kit for Human hVPS35
    ELISA Kit for Human hVPS35
    CLIA Kit for Human hVPS35
    CLIA Kit for Human hVPS35
    CLIA Kit for Human hVPS35
    Polyclonal Antibody for Human hVPS35
    Polyclonal Antibody for Human hVPS35
    Polyclonal Antibody for Human hVPS35
    Monoclonal Antibody for Human hVPS35
    Monoclonal Antibody for Human hVPS35
    Monoclonal Antibody for Human hVPS35
    Protein for Human hVPS35
    Protein for Human hVPS35
    Protein for Human hVPS35

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human homologues of yeast vacuolar protein sorting 29 and 35."
      Edgar A.J. , Polak J.M.
      Biochem. Biophys. Res. Commun.277:622-630(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    2. 2.
      "Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21."
      Zhang P. , Yu L. , Gao J. , Fu Q. , Dai F. , Zhao Y. , Zheng L. , Zhao S.
      Genomics70:253-257(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    3. 3.
      "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."
      Renfrew Haft C. , de la Luz Sierra M. , Bafford R. , Lesniak M.A. , Barr V.A. , Taylor S.I.
      Mol. Biol. Cell11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH VPS29; VPS26A; SNX1 AND SNX2
      tissue: Colon.
    4. 4.
      "A novel gene expressed in human pheochromocytoma."
      Peng Y. , Li Y. , Tu Y. , Xu S. , Han Z. , Fu G. , Chen Z.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pheochromocytoma.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ileal mucosa.
      tissue: Placenta.
      tissue: Teratocarcinoma.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Placenta.
      tissue: Prostate.
    8. 8.
      "Pediatric leukemia cDNA sequencing project."
      Zhou J. , Yu W. , Tang H. , Mei G. , Tsang Y.T.M. , Bouck J. , Gibbs R.A. , Margolin J.F.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-796
      tissue: Leukemia.
    9. 9.
      "Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor."
      Arighi C.N. , Hartnell L.M. , Aguilar R.C. , Haft C.R. , Bonifacino J.S.
      J. Cell Biol.165:123-133(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH IGF2R
    10. 10.
      "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."
      Verges M. , Luton F. , Gruber C. , Tiemann F. , Reinders L.G. , Huang L. , Burlingame A.L. , Haft C.R. , Mostov K.E.
      Nat. Cell Biol.6:763-769(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval."
      Gokool S. , Tattersall D. , Seaman M.N.
      Traffic8:1873-1886(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EHD1
    12. 12.
      "Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5."
      Seaman M.N. , Harbour M.E. , Tattersall D. , Read E. , Bright N.
      J. Cell Sci.122:2371-2382(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAB7A
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GOLPH3
    14. 14.
      "The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics."
      Harbour M.E. , Breusegem S.Y. , Antrobus R. , Freeman C. , Reid E. , Seaman M.N.
      J. Cell Sci.123:3703-3717(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1."
      Tabuchi M. , Yanatori I. , Kawai Y. , Kishi F.
      J. Cell Sci.123:756-766(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."
      Harterink M. , Port F. , Lorenowicz M.J. , McGough I.J. , Silhankova M. , Betist M.C. , van Weering J.R. , van Heesbeen R.G. , Middelkoop T.C. , Basler K. , Cullen P.J. , Korswagen H.C.
      Nat. Cell Biol.13:914-923(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE SNX3-RETROMER;SUBUNIT
    19. 19.
      "Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35."
      Harbour M.E. , Breusegem S.Y. , Seaman M.N.
      Biochem. J.442:209-220(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FAM21C; FKBP15 AND WASH1
    20. 20.
      "Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer."
      Jia D. , Gomez T.S. , Billadeau D.D. , Rosen M.K.
      Mol. Biol. Cell23:2352-2361(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FAM21C
    21. 21.
      "Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer."
      Helfer E. , Harbour M.E. , Henriot V. , Lakisic G. , Sousa-Blin C. , Volceanov L. , Seaman M.N. , Gautreau A.
      Biol. Cell105:191-207(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VPS29 AND VPS26;MUTAGENESIS OF LEU-108 AND HIS-675
    22. 22.
      "Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination."
      Hao Y.H. , Doyle J.M. , Ramanathan S. , Gomez T.S. , Jia D. , Xu M. , Chen Z.J. , Billadeau D.D. , Rosen M.K. , Potts P.R.
      Cell152:1051-1064(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAGEL2
    23. 23.
      "A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport."
      Steinberg F. , Gallon M. , Winfield M. , Thomas E.C. , Bell A.J. , Heesom K.J. , Tavare J.M. , Cullen P.J.
      Nat. Cell Biol.15:461-471(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE SNX27-RETROMER;SUBUNIT;INTERACTION WITH SNX27 AND KIAA0196
    24. 24.
      "RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk."
      MacLeod D.A. , Rhinn H. , Kuwahara T. , Zolin A. , Di Paolo G. , McCabe B.D. , MacCabe B.D. , Marder K.S. , Honig L.S. , Clark L.N. , Small S.A. , Abeliovich A.
      Neuron77:425-439(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RETROGRADE TRANSPORT;INTERACTION WITH LRRK2;CHARACTERIZATION OF VARIANT PARK17 ASN-620
    25. 25.
      "A mechanism for retromer endosomal coat complex assembly with cargo."
      Harrison M.S. , Hung C.S. , Liu T.T. , Christiano R. , Walther T.C. , Burd C.G.
      Proc. Natl. Acad. Sci. U.S.A.111:267-272(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX3 AND SLC11A2
    26. 26.
      "Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation."
      McGough I.J. , Steinberg F. , Jia D. , Barbuti P.A. , McMillan K.J. , Heesom K.J. , Whone A.L. , Caldwell M.A. , Billadeau D.D. , Rosen M.K. , Cullen P.J.
      Curr. Biol.24:1670-1676(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FAM21C;CHARACTERIZATION OF VARIANT PARK17 ASN-620
    27. 27.
      "Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy."
      Zavodszky E. , Seaman M.N. , Moreau K. , Jimenez-Sanchez M. , Breusegem S.Y. , Harbour M.E. , Rubinsztein D.C.
      Nat. Commun.5:3828-3828(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANT PARK17 ASN-620
    28. 28.
      "Functional architecture of the retromer cargo-recognition complex."
      Hierro A. , Rojas A.L. , Rojas R. , Murthy N. , Effantin G. , Kajava A.V. , Steven A.C. , Bonifacino J.S. , Hurley J.H.
      Nature449:1063-1067(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 483-780 IN COMPLEX WITH VPS29;ELECTRON MICROSCOPY OF THE RETROMER COMPLEX CONTAINING VPS29; VPS35 AND VPS26
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK17 ASN-620;VARIANTS SER-316 AND VAL-737
    30. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK17 ASN-620;VARIANTS SER-51; ILE-57; ARG-82; MET-241; TRP-524 AND MET-774
    31. 31.
      "Identification of VPS35 mutations replicated in French families with Parkinson disease."
      Lesage S. , Condroyer C. , Klebe S. , Honore A. , Tison F. , Brefel-Courbon C. , Durr A. , Brice A.
      Neurology78:1449-1450(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARK17 ASN-620
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