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Index > Protein center > Vrk2(Gene name) > Mouse
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  • Vrk2 (Gene name),
  • Serine/threonine-protein kinase VRK2 (Protein name ),  VRK2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Vrk2;
    Protein name:
    Serine/threonine-protein kinase VRK2;
    Alternative:
    Vaccinia-related kinase 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MAP3K7, MAP2K7, MAP2K1, KSR1, RAN and MAPK8IP1.
    Function:
    Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes, reduces JNK phosphorylation and AP1-dependent transcription. Phosphorylates: 'Thr-18' of p53/TP53, casein, MBP, histone H2B, histone H3 and MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS.
    Subcellular Location:
    Cytoplasm Endoplasmic reticulum membrane Single-pass type IV membrane protein Mitochondrion membrane Single-pass type IV membrane protein
    Protein Attributes:
    Sequence length:
    503
    Sequence:
    50:
    MAPRRKEKYK | LPVPLPEGKI | LDDMEGNRWA | LGKMIGSGGF | GLIYLAFPTN | 
    100:
    KPNKDARHVI | KLEYQENGPL | FSELKFYQRA | AKRECIQKWI | QQRKLDYLGI | 
    150:
    PVFYGFGLTD | FKGRSYRFMV | MERLGIDLQK | LLDQNGGFKK | LTVLQLGIRM | 
    200:
    LDVLEYIHEN | EYVHGDIKAA | NLLLDFTNPD | RVYLADYGLS | YRYCPNGNHK | 
    250:
    QYQEDPRKGH | NGTIEFTSLD | AHKGVAPSRR | SDVEILGYCM | LHWLFGKLPW | 
    300:
    EAKLDDPVAV | QTAKTNLLDE | LPESVLKWAP | SGSSCSELVK | YLMYVHNLAY | 
    350:
    DDKPDYQKLK | KILNPDGVPL | GPLEFSTKVQ | SVHVRTPAQQ | KVDSPKATRK | 
    400:
    PANEFPAKFP | KKVHRETRAR | QREEQEDSQP | TMLQSRPAAP | ENSRTRKIHE | 
    450:
    YSDIFSEMQS | LQQTPSYMSF | QGSYCKPYLD | CTRRDPIRKP | RSLPRYRHTP | 
    500:
    TGNLGVTDLE | SSPRFWPAIF | QLTLSEETKA | DVYYYGITIF | CLLIFVFLAL | 
    503:
    YFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Serine/threonine-protein kinase VRK2
    ELISA Kit for Mouse Serine/threonine-protein kinase VRK2
    CLIA Kit for Mouse Serine/threonine-protein kinase VRK2
    CLIA Kit for Mouse Serine/threonine-protein kinase VRK2
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase VRK2
    Polyclonal Antibody for Mouse Serine/threonine-protein kinase VRK2
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase VRK2
    Monoclonal Antibody for Mouse Serine/threonine-protein kinase VRK2
    Protein for Mouse Serine/threonine-protein kinase VRK2
    Protein for Mouse Serine/threonine-protein kinase VRK2

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd."
      Agoulnik A.I. , Lu B. , Zhu Q. , Truong C. , Ty M.T. , Arango N. , Chada K.K. , Bishop C.E.
      Hum. Mol. Genet.11:3047-3053(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Dendritic cell.
      tissue: Embryo.
      tissue: Eye.
      tissue: Spleen.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Kidney.
    5. 5.
      "Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development."
      Vega F.M. , Gonzalo P. , Gaspar M.L. , Lazo P.A.
      FEBS Lett.544:176-180(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    6. 6.
      "Characterization of three paralogous members of the Mammalian vaccinia related kinase family."
      Nichols R.J. , Traktman P.
      J. Biol. Chem.279:7934-7946(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION
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