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Index > Protein center > VSIG4(Gene name) > Human
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  • VSIG4 (Gene name),
  • V-set and immunoglobulin domain-containing protein 4 (Protein name ),  VSIG4_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    VSIG4(UNQ317/PRO362;CRIg;Z39IG);
    Protein name:
    V-set and immunoglobulin domain-containing protein 4;
    Alternative:
    Protein Z39Ig;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    399
    Sequence:
    50:
    MGILLGLLLL | GHLTVDTYGR | PILEVPESVT | GPWKGDVNLP | CTYDPLQGYT | 
    100:
    QVLVKWLVQR | GSDPVTIFLR | DSSGDHIQQA | KYQGRLHVSH | KVPGDVSLQL | 
    150:
    STLEMDDRSH | YTCEVTWQTP | DGNQVVRDKI | TELRVQKLSV | SKPTVTTGSG | 
    200:
    YGFTVPQGMR | ISLQCQARGS | PPISYIWYKQ | QTNNQEPIKV | ATLSTLLFKP | 
    250:
    AVIADSGSYF | CTAKGQVGSE | QHSDIVKFVV | KDSSKLLKTK | TEAPTTMTYP | 
    300:
    LKATSTVKQS | WDWTTDMDGY | LGETSAGPGK | SLPVFAIILI | ISLCCMVVFT | 
    350:
    MAYIMLCRKT | SQQEHVYEAA | RAHAREANDS | GETMRVAIFA | SGCSSDEPTS | 
    399:
    QNLGNNYSDE | PCIGQEYQII | AQINGNYARL | LDTVPLDYEF | LATEGKSVC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    SMR:
    UniGene:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human V-set and immunoglobulin domain-containing protein 4
    Cat.:
    E4929h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human V-set and immunoglobulin domain-containing protein 4
    Cat.:
    U4929h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human V-set and immunoglobulin domain-containing protein 4
    Cat.:
    P4929Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human V-set and immunoglobulin domain-containing protein 4
    Protein for Human V-set and immunoglobulin domain-containing protein 4

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning of Z39Ig, a novel gene with immunoglobulin-like domains located on human chromosome X."
      Langnaese K. , Colleaux L. , Kloos D.U. , Fontes M. , Wieacker P.
      Biochim. Biophys. Acta1492:522-525(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    3. 3.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Placenta.
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-34
    7. 7.
      "VSIG4, a B7 family-related protein, is a negative regulator of T cell activation."
      Vogt L. , Schmitz N. , Kurrer M.O. , Bauer M. , Hinton H.I. , Behnke S. , Gatto D. , Sebbel P. , Beerli R.R. , Sonderegger I. , Kopf M. , Saudan P. , Bachmann M.F.
      J. Clin. Invest.116:2817-2826(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    8. 8.
      "Structure of C3b in complex with CRIg gives insights into regulation of complement activation."
      Wiesmann C. , Katschke K.J. , Yin J. , Helmy K.Y. , Steffek M. , Fairbrother W.J. , McCallum S.A. , Embuscado L. , DeForge L. , Hass P.E. , van Lookeren Campagne M.
      Nature444:217-220(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.2 ANGSTROMS) OF 19-137 IN COMPLEX WITH C3B AND C3C;FUNCTION;DISULFIDE BOND
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