Protein name:
Vacuolar protein sorting-associated protein VTA1 homolog ;
Alternative:
SKD1-binding protein 1 (SBP1) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. May interact with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.
Function:
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR.
Subcellular Location:
Cytoplasm
Endosome membrane
Peripheral membrane protein
Protein Attributes:
50:
MAALAPLPPL | PAQFKSIQHH | LRTAQEHDKR | DPVVAYYCRL | YAMQTGMKID |
100:
SKTPECRKFL | SKLMDQLEAL | KKQLGDNEAV | TQEIVGCAHL | ENYALKMFLY |
150:
ADNEDRAGRF | HKNMIKSFYT | ASLLIDVITV | FGELTDENVK | HRKYARWKAT |
200:
YIHNCLKNGE | TPQAGPVGIE | EENDVEENED | VGATSLPTQP | PQPSSSSAYD |
250:
PSNLAPGSYS | GIQIPPGAHA | PANTPAEVPH | STGVTSNAVQ | PSPQTVPAAP |
300:
AVDPDLYTAS | QGDIRLTPED | FARAQKYCKY | AGSALQYEDV | GTAVQNLQKA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
ELISA Kit for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
ELISA Kit for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
ELISA Kit for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
CLIA Kit for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
CLIA Kit for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
CLIA Kit for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Polyclonal Antibody for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Monoclonal Antibody for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Protein for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Protein for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
Protein for Mouse Vacuolar protein sorting-associated protein VTA1 homolog
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Kidney .
tissue :
Tongue .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.
"Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B."
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Umezuki Y.
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Imamura K.
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Ishikawa D.
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J. Cell Sci.117:2997-3009(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH VPS4B;TISSUE SPECIFICITY;SUBCELLULAR LOCATION