Gene name:
WASF1 (KIAA0269;SCAR1;WAVE1) ;
Protein name:
Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) ;
Alternative:
Verprolin homology domain-containing protein 1 ;Protein WAVE-1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2.
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Location:
Cytoplasm
cytoskeleton
Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
Protein Attributes:
50:
MPLVKRNIDP | RHLCHTALPR | GIKNELECVT | NISLANIIRQ | LSSLSKYAED |
100:
IFGELFNEAH | SFSFRVNSLQ | ERVDRLSVSV | TQLDPKEEEL | SLQDITMRKA |
150:
FRSSTIQDQQ | LFDRKTLPIP | LQETYDVCEQ | PPPLNILTPY | RDDGKEGLKF |
200:
YTNPSYFFDL | WKEKMLQDTE | DKRKEKRKQK | QKNLDRPHEP | EKVPRAPHDR |
250:
RREWQKLAQG | PELAEDDANL | LHKHIEVANG | PASHFETRPQ | TYVDHMDGSY |
300:
SLSALPFSQM | SELLTRAEER | VLVRPHEPPP | PPPMHGAGDA | KPIPTCISSA |
350:
TGLIENRPQS | PATGRTPVFV | SPTPPPPPPP | LPSALSTSSL | RASMTSTPPP |
400:
PVPPPPPPPA | TALQAPAVPP | PPAPLQIAPG | VLHPAPPPIA | PPLVQPSPPV |
450:
ARAAPVCETV | PVHPLPQGEV | QGLPPPPPPP | PLPPPGIRPS | SPVTVTALAH |
500:
PPSGLHPTPS | TAPGPHVPLM | PPSPPSQVIP | ASEPKRHPST | LPVISDARSV |
550:
LLEAIRKGIQ | LRKVEEQREQ | EAKHERIEND | VATILSRRIA | VEYSDSEDDS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Rat
Human
ELISA Kit for Human WASP family protein member 1
ELISA Kit for Human WASP family protein member 1
ELISA Kit for Human WASP family protein member 1
ELISA Kit for Human WASP family protein member 1
CLIA Kit for Human WASP family protein member 1
CLIA Kit for Human WASP family protein member 1
CLIA Kit for Human WASP family protein member 1
CLIA Kit for Human WASP family protein member 1
Polyclonal Antibody for Human WASP family protein member 1
Polyclonal Antibody for Human WASP family protein member 1
Polyclonal Antibody for Human WASP family protein member 1
Polyclonal Antibody for Human WASP family protein member 1
Monoclonal Antibody for Human WASP family protein member 1
Monoclonal Antibody for Human WASP family protein member 1
Monoclonal Antibody for Human WASP family protein member 1
Monoclonal Antibody for Human WASP family protein member 1
Protein for Human WASP family protein member 1
Protein for Human WASP family protein member 1
Protein for Human WASP family protein member 1
Protein for Human WASP family protein member 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Bone marrow .
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Nature425:805-811(2003)
[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BAIAP2
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF WAVE1 COMPLEX;SUBUNIT