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Index > Protein center > WASF1(Gene name) > Human
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  • WASF1 (Gene name),
  • Wiskott-Aldrich syndrome protein family member 1 (Protein name ),  WASF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    WASF1(KIAA0269;SCAR1;WAVE1);
    Protein name:
    Wiskott-Aldrich syndrome protein family member 1(WASP family protein member 1);
    Alternative:
    Verprolin homology domain-containing protein 1;Protein WAVE-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2.
    Function:
    Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
    Subcellular Location:
    Cytoplasm cytoskeleton Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
    Protein Attributes:
    Sequence length:
    559
    Sequence:
    50:
    MPLVKRNIDP | RHLCHTALPR | GIKNELECVT | NISLANIIRQ | LSSLSKYAED | 
    100:
    IFGELFNEAH | SFSFRVNSLQ | ERVDRLSVSV | TQLDPKEEEL | SLQDITMRKA | 
    150:
    FRSSTIQDQQ | LFDRKTLPIP | LQETYDVCEQ | PPPLNILTPY | RDDGKEGLKF | 
    200:
    YTNPSYFFDL | WKEKMLQDTE | DKRKEKRKQK | QKNLDRPHEP | EKVPRAPHDR | 
    250:
    RREWQKLAQG | PELAEDDANL | LHKHIEVANG | PASHFETRPQ | TYVDHMDGSY | 
    300:
    SLSALPFSQM | SELLTRAEER | VLVRPHEPPP | PPPMHGAGDA | KPIPTCISSA | 
    350:
    TGLIENRPQS | PATGRTPVFV | SPTPPPPPPP | LPSALSTSSL | RASMTSTPPP | 
    400:
    PVPPPPPPPA | TALQAPAVPP | PPAPLQIAPG | VLHPAPPPIA | PPLVQPSPPV | 
    450:
    ARAAPVCETV | PVHPLPQGEV | QGLPPPPPPP | PLPPPGIRPS | SPVTVTALAH | 
    500:
    PPSGLHPTPS | TAPGPHVPLM | PPSPPSQVIP | ASEPKRHPST | LPVISDARSV | 
    550:
    LLEAIRKGIQ | LRKVEEQREQ | EAKHERIEND | VATILSRRIA | VEYSDSEDDS | 
    559:
    EFDEVDWLE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human WASP family protein member 1
    ELISA Kit for Human WASP family protein member 1
    ELISA Kit for Human WASP family protein member 1
    ELISA Kit for Human WASP family protein member 1
    CLIA Kit for Human WASP family protein member 1
    CLIA Kit for Human WASP family protein member 1
    CLIA Kit for Human WASP family protein member 1
    CLIA Kit for Human WASP family protein member 1
    Polyclonal Antibody for Human WASP family protein member 1
    Polyclonal Antibody for Human WASP family protein member 1
    Polyclonal Antibody for Human WASP family protein member 1
    Polyclonal Antibody for Human WASP family protein member 1
    Monoclonal Antibody for Human WASP family protein member 1
    Monoclonal Antibody for Human WASP family protein member 1
    Monoclonal Antibody for Human WASP family protein member 1
    Monoclonal Antibody for Human WASP family protein member 1
    Protein for Human WASP family protein member 1
    Protein for Human WASP family protein member 1
    Protein for Human WASP family protein member 1
    Protein for Human WASP family protein member 1

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    Linearity
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    References
    1. 1.
      "SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development."
      Bear J.E. , Rawls J.F. , Saxe C.L. III
      J. Cell Biol.142:1325-1335(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T. , Seki N. , Ishikawa K. , Ohira M. , Kawarabayasi Y. , Ohara O. , Tanaka A. , Kotani H. , Miyajima N. , Nomura N.
      DNA Res.3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    6. 6.
      "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex."
      Machesky L.M. , Insall R.H.
      Curr. Biol.8:1347-1356(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    7. 7.
      "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling."
      Miki H. , Yamaguchi H. , Suetsugu S. , Takenawa T.
      Nature408:732-735(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAIAP2
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF WAVE1 COMPLEX;SUBUNIT
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