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Index > Protein center > WASF2(Gene name) > Human
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  • WASF2 (Gene name),
  • Wiskott-Aldrich syndrome protein family member 2 (Protein name ),  WASF2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    WASF2(WAVE2);
    Protein name:
    Wiskott-Aldrich syndrome protein family member 2(WASP family protein member 2);
    Alternative:
    Verprolin homology domain-containing protein 2;Protein WAVE-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1.
    Function:
    Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell projection lamellipodium At the interface between the lamellipodial actin meshwork and the membrane.
    Protein Attributes:
    Sequence length:
    498
    Sequence:
    50:
    MPLVTRNIEP | RHLCRQTLPS | VRSELECVTN | ITLANVIRQL | GSLSKYAEDI | 
    100:
    FGELFTQANT | FASRVSSLAE | RVDRLQVKVT | QLDPKEEEVS | LQGINTRKAF | 
    150:
    RSSTIQDQKL | FDRNSLPVPV | LETYNTCDTP | PPLNNLTPYR | DDGKEALKFY | 
    200:
    TDPSYFFDLW | KEKMLQDTKD | IMKEKRKHRK | EKKDNPNRGN | VNPRKIKTRK | 
    250:
    EEWEKMKMGQ | EFVESKEKLG | TSGYPPTLVY | QNGSIGCVEN | VDASSYPPPP | 
    300:
    QSDSASSPSP | SFSEDNLPPP | PAEFSYPVDN | QRGSGLAGPK | RSSVVSPSHP | 
    350:
    PPAPPLGSPP | GPKPGFAPPP | APPPPPPPMI | GIPPPPPPVG | FGSPGTPPPP | 
    400:
    SPPSFPPHPD | FAAPPPPPPP | PAADYPTLPP | PPLSQPTGGA | PPPPPPPPPP | 
    450:
    GPPPPPFTGA | DGQPAIPPPL | SDTTKPKSSL | PAVSDARSDL | LSAIRQGFQL | 
    498:
    RRVEEQREQE | KRDVVGNDVA | TILSRRIAVE | YSDSEDDSSE | FDEDDWSD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human WASP family protein member 2
    ELISA Kit for Human WASP family protein member 2
    ELISA Kit for Human WASP family protein member 2
    CLIA Kit for Human WASP family protein member 2
    CLIA Kit for Human WASP family protein member 2
    CLIA Kit for Human WASP family protein member 2
    Polyclonal Antibody for Human WASP family protein member 2
    Polyclonal Antibody for Human WASP family protein member 2
    Polyclonal Antibody for Human WASP family protein member 2
    Monoclonal Antibody for Human WASP family protein member 2
    Monoclonal Antibody for Human WASP family protein member 2
    Monoclonal Antibody for Human WASP family protein member 2
    Protein for Human WASP family protein member 2
    Protein for Human WASP family protein member 2
    Protein for Human WASP family protein member 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex."
      Suetsugu S. , Miki H. , Takenawa T.
      Biochem. Biophys. Res. Commun.260:296-302(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH ACTIN AND THE ARP2/3 COMPLEX;SUBUNIT;DOMAIN;TISSUE SPECIFICITY
      tissue: T-cell lymphoma.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lymph.
    5. 5.
      "IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling."
      Miki H. , Yamaguchi H. , Suetsugu S. , Takenawa T.
      Nature408:732-735(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAIAP2
    6. 6.
      "Purification and architecture of the ubiquitous Wave complex."
      Gautreau A. , Ho H.-Y. , Li J. , Steen H. , Gygi S.P. , Kirschner M.W.
      Proc. Natl. Acad. Sci. U.S.A.101:4379-4383(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C3ORF10
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-40; ILE-50; PHE-51 AND LEU-54;SUBUNIT
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly."
      Chereau D. , Kerff F. , Graceffa P. , Grabarek Z. , Langsetmo K. , Dominguez R.
      Proc. Natl. Acad. Sci. U.S.A.102:16644-16649(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 433-464 IN COMPLEX WITH ACTIN;FUNCTION;DOMAIN;MUTAGENESIS OF TYR-124; TYR-150 AND 160-TRP-LYS-161;SUBUNIT
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