Protein name:
Wiskott-Aldrich syndrome protein family member 2 (WASP family protein member 2) ;
Alternative:
Verprolin homology domain-containing protein 2 ;Protein WAVE-2 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1.
Function:
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Subcellular Location:
Cytoplasm
cytoskeleton
Cell projection
lamellipodium
At the interface between the lamellipodial actin meshwork and the membrane.
Protein Attributes:
50:
MPLVTRNIEP | RHLCRQTLPS | VRSELECVTN | ITLANVIRQL | GSLSKYAEDI |
100:
FGELFTQANT | FASRVSSLAE | RVDRLQVKVT | QLDPKEEEVS | LQGINTRKAF |
150:
RSSTIQDQKL | FDRNSLPVPV | LETYNTCDTP | PPLNNLTPYR | DDGKEALKFY |
200:
TDPSYFFDLW | KEKMLQDTKD | IMKEKRKHRK | EKKDNPNRGN | VNPRKIKTRK |
250:
EEWEKMKMGQ | EFVESKEKLG | TSGYPPTLVY | QNGSIGCVEN | VDASSYPPPP |
300:
QSDSASSPSP | SFSEDNLPPP | PAEFSYPVDN | QRGSGLAGPK | RSSVVSPSHP |
350:
PPAPPLGSPP | GPKPGFAPPP | APPPPPPPMI | GIPPPPPPVG | FGSPGTPPPP |
400:
SPPSFPPHPD | FAAPPPPPPP | PAADYPTLPP | PPLSQPTGGA | PPPPPPPPPP |
450:
GPPPPPFTGA | DGQPAIPPPL | SDTTKPKSSL | PAVSDARSDL | LSAIRQGFQL |
498:
RRVEEQREQE | KRDVVGNDVA | TILSRRIAVE | YSDSEDDSSE | FDEDDWSD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
ELISA Kit for Human WASP family protein member 2
ELISA Kit for Human WASP family protein member 2
ELISA Kit for Human WASP family protein member 2
CLIA Kit for Human WASP family protein member 2
CLIA Kit for Human WASP family protein member 2
CLIA Kit for Human WASP family protein member 2
Polyclonal Antibody for Human WASP family protein member 2
Polyclonal Antibody for Human WASP family protein member 2
Polyclonal Antibody for Human WASP family protein member 2
Monoclonal Antibody for Human WASP family protein member 2
Monoclonal Antibody for Human WASP family protein member 2
Monoclonal Antibody for Human WASP family protein member 2
Protein for Human WASP family protein member 2
Protein for Human WASP family protein member 2
Protein for Human WASP family protein member 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH ACTIN AND THE ARP2/3 COMPLEX;SUBUNIT;DOMAIN;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lymph .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BAIAP2
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH C3ORF10
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF LEU-40; ILE-50; PHE-51 AND LEU-54;SUBUNIT
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 433-464 IN COMPLEX WITH ACTIN;FUNCTION;DOMAIN;MUTAGENESIS OF TYR-124; TYR-150 AND 160-TRP-LYS-161;SUBUNIT