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Index > Protein center > WDR4(Gene name) > Human
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  • WDR4 (Gene name),
  • tRNA (guanine-N(7)-)-methyltransferase subunit WDR4 (Protein name ),  WDR4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WDR4;
    Protein name:
    tRNA (guanine-N(7)-)-methyltransferase subunit WDR4;
    Alternative:
    WD repeat-containing protein 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with METTL1.
    Function:
    Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    412
    Sequence:
    50:
    MAGSVGLALC | GQTLVVRGGS | RFLATSIASS | DDDSLFIYDC | SAAEKKSQEN | 
    100:
    KGEDAPLDQG | SGAILASTFS | KSGSYFALTD | DSKRLILFRT | KPWQCLSVRT | 
    150:
    VARRCTALTF | IASEEKVLVA | DKSGDVYSFS | VLEPHGCGRL | ELGHLSMLLD | 
    200:
    VAVSPDDRFI | LTADRDEKIR | VSWAAAPHSI | ESFCLGHTEF | VSRISVVPTQ | 
    250:
    PGLLLSSSGD | GTLRLWEYRS | GRQLHCCHLA | SLQELVDPQA | PQKFAASRIA | 
    300:
    FWCQENCVAL | LCDGTPVVYI | FQLDARRQQL | VYRQQLAFQH | QVWDVAFEET | 
    350:
    QGLWVLQDCQ | EAPLVLYRPV | GDQWQSVPES | TVLKKVSGVL | RGNWAMLEGS | 
    400:
    AGADASFSSL | YKATFDNVTS | YLKKKEERLQ | QQLEKKQRRR | SPPPGPDGHA | 
    412:
    KKMRPGEATL | SC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    KEGG:
    MIM:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    ELISA Kit for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    ELISA Kit for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    CLIA Kit for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    CLIA Kit for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    CLIA Kit for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Polyclonal Antibody for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Polyclonal Antibody for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Polyclonal Antibody for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Monoclonal Antibody for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Monoclonal Antibody for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Monoclonal Antibody for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Protein for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Protein for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4
    Protein for Human tRNA (guanine-N(7)-)-methyltransferase subunit WDR4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein."
      Michaud J. , Kudoh J. , Berry A. , Bonne-Tamir B. , Lalioti M.D. , Rossier C. , Shibuya K. , Kawasaki K. , Asakawa S. , Minoshima S. , Shimizu N. , Antonarakis S.E. , Scott H.S.
      Genomics68:71-79(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANTS ASN-71 AND SER-266
      tissue: Lung.
      tissue: Trachea.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ASN-71
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANT SER-266
      tissue: Lung.
      tissue: Uterus.
    5. 6.
      Bienvenut W.V.
      Submitted (2010-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-17 AND 105-116;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Ovarian carcinoma.
    6. 7.
      "Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA."
      Alexandrov A. , Martzen M.R. , Phizicky E.M.
      RNA8:1253-1266(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH METTL1
    7. 8.
      "The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells."
      Cartlidge R.A. , Knebel A. , Peggie M. , Alexandrov A. , Phizicky E.M. , Cohen P.
      EMBO J.24:1696-1705(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH METTL1
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 12.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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