WDR5 ELISA Kit for Human(Homo sapiens) | EIAab.comWDR5 ELISA Kit for Human(Homo sapiens)

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WDR5 (Gene name),

WD repeat-containing protein 5 (Protein name ), WDR5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

WDR5(BIG3);

Protein name:

WD repeat-containing protein 5;

Alternative:

BMP2-induced 3-kb gene protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, IN80C, KDM6A, KIAA1267, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with MLL and RBBP5; the interaction is direct. Component ofthe ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, MBIP and CSRP2BP. Interacts with histone H3. Interacts with SETD1A.

Function:

Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. May regulate osteoblasts differentiation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

334

Sequence:

50:

100:

150:

200:

250:

300:

334:

TDVVISTACH | PTENIIASAA | LENDKTIKLW | KSDC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:11091

Pfam:

PF00400

MIM:

609012

STRING:

9606.ENSP00000351446

SMR:

P61964

UniGene:

Hs.397638

String:

P61964

Uniprot:

P61964

FOR

ELISA Kit for Human WD repeat-containing protein 5

CLIA Kit for Human WD repeat-containing protein 5

Polyclonal Antibody for Human WD repeat-containing protein 5

Monoclonal Antibody for Human WD repeat-containing protein 5

Protein for Human WD repeat-containing protein 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of a sugar transporter gene, a G-beta subunit like gene and three novel genes in human chromosome 9q34."
Young J.M. , Woodward K.J. , Aziz S. , Burley M. , Kwiatkowski D.J. , Povey S.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Uterus.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
4.

"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."
Wysocka J. , Myers M.P. , Laherty C.D. , Eisenman R.N. , Herr W.
Genes Dev.17:896-911(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCFC1
5.

"Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus."
Hughes C.M. , Rozenblatt-Rosen O. , Milne T.A. , Copeland T.D. , Levine S.S. , Lee J.C. , Hayes D.N. , Shanmugam K.S. , Bhattacharjee A. , Biondi C.A. , Kay G.F. , Hayward N.K. , Hess J.L. , Meyerson M.
Mol. Cell13:587-597(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MEN1-ASSOCIATED HISTONE METHYLTRANSFERASE COMPLEX
6.

"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."
Yokoyama A. , Wang Z. , Wysocka J. , Sanyal M. , Aufiero D.J. , Kitabayashi I. , Herr W. , Cleary M.L.
Mol. Cell. Biol.24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MLL-LIKE COMPLEX
7.

"CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex."
Lee J.-H. , Skalnik D.G.
J. Biol. Chem.280:41725-41731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SET1 COMPLEX
8.

"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."
Dou Y. , Milne T.A. , Tackett A.J. , Smith E.R. , Fukuda A. , Wysocka J. , Allis C.D. , Chait B.T. , Hess J.L. , Roeder R.G.
Cell121:873-885(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MLL1/MLL COMPLEX
9.

"Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases."
Lee S. , Lee D.K. , Dou Y. , Lee J. , Lee B. , Kwak E. , Kong Y.Y. , Lee S.K. , Roeder R.G. , Lee J.W.
Proc. Natl. Acad. Sci. U.S.A.103:15392-15397(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MLL2/3 (ASCOM) COMPLEX
10.

"Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex."
Lee J.-H. , Tate C.M. , You J.-S. , Skalnik D.G.
J. Biol. Chem.282:13419-13428(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;IDENTIFICATION IN THE SET1 COMPLEX
11.

"PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."
Cho Y.-W. , Hong T. , Hong S. , Guo H. , Yu H. , Kim D. , Guszczynski T. , Dressler G.R. , Copeland T.D. , Kalkum M. , Ge K.
J. Biol. Chem.282:20395-20406(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MLL2/3 COMPLEX
12.

"Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes."
Lee J.H. , Skalnik D.G.
Mol. Cell. Biol.28:609-618(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN SET1 COMPLEX;INTERACTION WITH SETD1A
13.

"CHD8 is an ATP-dependent chromatin remodeling factor that regulates beta-catenin target genes."
Thompson B.A. , Tremblay V. , Lin G. , Bochar D.A.
Mol. Cell. Biol.28:3894-3904(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CHD8
14.

"Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS."
Wu M. , Wang P.F. , Lee J.S. , Martin-Brown S. , Florens L. , Washburn M. , Shilatifard A.
Mol. Cell. Biol.28:7337-7344(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN SET1 COMPLEX
15.

"Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation."
Garapaty S. , Xu C.F. , Trojer P. , Mahajan M.A. , Neubert T.A. , Samuels H.H.
J. Biol. Chem.284:7542-7552(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH ASCL2; C11ORF30; HCFC1; HSPA8; CCAR2; MATR3; MKI67; RBBP5 AND ZNF335
16.

"On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex."
Patel A. , Dharmarajan V. , Vought V.E. , Cosgrove M.S.
J. Biol. Chem.284:24242-24256(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF THE MLL1/MLL COMPLEX;INTERACTION WITH KMT2A AND RBBP5
17.

"The double-histone-acetyltransferase complex ATAC is essential for mammalian development."
Guelman S. , Kozuka K. , Mao Y. , Pham V. , Solloway M.J. , Wang J. , Wu J. , Lill J.R. , Zha J.
Mol. Cell. Biol.29:1176-1188(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN ATAC COMPLEX
18.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex."
Cai Y. , Jin J. , Swanson S.K. , Cole M.D. , Choi S.H. , Florens L. , Washburn M.P. , Conaway J.W. , Conaway R.C.
J. Biol. Chem.285:4268-4272(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HISTONE H4 ACETYLATION;IDENTIFICATION IN NSL COMPLEX;SUBCELLULAR LOCATION
20.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation."
Yang Y.J. , Baltus A.E. , Mathew R.S. , Murphy E.A. , Evrony G.D. , Gonzalez D.M. , Wang E.P. , Marshall-Walker C.A. , Barry B.J. , Murn J. , Tatarakis A. , Mahajan M.A. , Samuels H.H. , Shi Y. , Golden J.A. , Mahajnah M. , Shenhav R. , Walsh C.A.
Cell151:1097-1112(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF335
22.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
23.

"Structural basis for molecular recognition and presentation of histone H3 by WDR5."
Schuetz A. , Allali-Hassani A. , Martin F. , Loppnau P. , Vedadi M. , Bochkarev A. , Plotnikov A.N. , Arrowsmith C.H. , Min J.
EMBO J.25:4245-4252(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH HISTONE H3 PEPTIDE;INTERACTION WITH HISTONE H3
24.

"Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5."
Han Z. , Guo L. , Wang H. , Shen Y. , Deng X.W. , Chai J.
Mol. Cell22:137-144(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 27-334 IN COMPLEX WITH HISTONE H3 PEPTIDE;INTERACTION WITH HISTONE H3;MUTAGENESIS OF ALA-47; SER-91; ASP-107; PHE-133 AND GLU-322;FUNCTION
25.

"Molecular recognition of histone H3 by the WD40 protein WDR5."
Couture J.F. , Collazo E. , Trievel R.C.
Nat. Struct. Mol. Biol.13:698-703(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) OF 22-334 IN COMPLEX WITH HISTONE H3 PEPTIDE;INTERACTION WITH HISTONE H3;MUTAGENESIS OF ASP-107; PHE-133; PHE-263 AND LEU-321;FUNCTION
26.

"Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex."
Ruthenburg A.J. , Wang W. , Graybosch D.M. , Li H. , Allis C.D. , Patel D.J. , Verdine G.L.
Nat. Struct. Mol. Biol.13:704-712(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-334 IN COMPLEX WITH HISTONE H3 PEPTIDE;INTERACTION WITH HISTONE H3
27.

"Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide."
Patel A. , Dharmarajan V. , Cosgrove M.S.
J. Biol. Chem.283:32158-32161(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 23-334 IN COMPLEX WITH KMT2A
28.

"WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket."
Song J.J. , Kingston R.E.
J. Biol. Chem.283:35258-35264(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.37 ANGSTROMS) OF 25-334 IN COMPLEX WITH KMT2A PEPTIDE;SUBUNIT

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