WDR83 ELISA Kit for Human(Homo sapiens) | EIAab.comWDR83 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > WDR83(Gene name) > Human

WDR83 (Gene name),

WD repeat domain-containing protein 83 (Protein name ), WDR83_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

WDR83(MORG1);

Protein name:

WD repeat domain-containing protein 83;

Alternative:

Mitogen-activated protein kinase organizer 1(MAPK organizer 1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.

Function:

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

Subcellular Location:

Cytoplasm Nucleus Predominantly cytoplasmic (By similarity). Partially nuclear.

Protein Attributes:

Sequence length:

315

Sequence:

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