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Index > Protein center > Wee1(Gene name) > Mouse
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  • Wee1 (Gene name),
  • Wee1-like protein kinase (Protein name ),  WEE1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Wee1;
    Protein name:
    Wee1-like protein kinase;
    Alternative:
    Wee1A kinase;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds to 14-3-3 protein zeta.
    Function:
    Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    646
    Sequence:
    50:
    MSFLSRQQPP | PTRRVGAAYS | LRQKLIFSPG | SDCEEEEEEE | EEGSGHSTGE | 
    100:
    DSAFQEPDSP | LPSARSPAEA | EAERRRRSPG | AEPSSPGELE | DDLLLQGGGG | 
    150:
    GAQAAGGGAE | GDSWEEEGFG | SSSPVKSPST | AYFLSSPFSP | VRCGGPGDAS | 
    200:
    PQGCGAPRAM | DDPCSPQPDY | PSTPPHKTFR | KLRLFDTPHT | PKSLLSKARV | 
    250:
    IDSGSVKLRG | SSLFMDTEKS | GKREFDTRQT | PQVNINPFTP | DPVLLHSSGR | 
    300:
    CRGRKRAYFN | DSSEDMEASD | YEFEDETRPA | KRITITESNM | KSRYTTEFHE | 
    350:
    LEKIGSGEFG | SVFKCVKRLD | GCIYAIKRSK | KPLAGSVDEQ | NALREVYAHA | 
    400:
    VLGQHPHVVR | YFSAWAEDDH | MLIQNEYCNG | GSLADAISEN | YRVMSYLTEV | 
    450:
    ELKDLLLQVG | RGLRYIHSMS | LVHMDIKPSN | IFISRTSIPN | AVSEEGDEDD | 
    500:
    WISNKVMFKI | GDLGHVTRIS | SPQVEEGDSR | FLANEVLQEN | YSHLPKADIF | 
    550:
    ALALTVVCAA | GAEPLPRNGE | QWHEIRQGRL | PRIPQVLSQE | VTELLRVMIH | 
    600:
    PDPERRPSAM | ELVKHSVLLS | ASRKSAEQLR | IELNAEKFKN | SLLQKELKKA | 
    646:
    QMAAKVAAEE | RALFTDRMAT | RSTTQSNRTS | RLIGKKMNRS | VSLTIY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Wee1-like protein kinase
    ELISA Kit for Mouse Wee1-like protein kinase
    ELISA Kit for Mouse Wee1-like protein kinase
    CLIA Kit for Mouse Wee1-like protein kinase
    CLIA Kit for Mouse Wee1-like protein kinase
    CLIA Kit for Mouse Wee1-like protein kinase
    Polyclonal Antibody for Mouse Wee1-like protein kinase
    Polyclonal Antibody for Mouse Wee1-like protein kinase
    Polyclonal Antibody for Mouse Wee1-like protein kinase
    Monoclonal Antibody for Mouse Wee1-like protein kinase
    Monoclonal Antibody for Mouse Wee1-like protein kinase
    Monoclonal Antibody for Mouse Wee1-like protein kinase
    Protein for Mouse Wee1-like protein kinase
    Protein for Mouse Wee1-like protein kinase
    Protein for Mouse Wee1-like protein kinase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation."
      Honda R. , Tanaka H. , Ohba Y. , Yasuda H.
      Chromosome Res.3:300-308(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6.
      tissue: Calvaria.
    2. 2.
      "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)."
      Cichutek A. , Brueckmann T. , Seipel B. , Hauser H. , Schlaubitz S. , Prawitt D. , Hankeln T. , Schmidt E.R. , Winterpacht A. , Zabel B.U.
      Cytogenet. Cell Genet.93:277-283(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase."
      Honda R. , Ohba Y. , Yasuda H.
      Biochem. Biophys. Res. Commun.230:262-265(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH 14-3-3 ZETA
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